1 research outputs found
A Selective Luminescent Probe for the Direct Time-Gated Detection of Adenosine Triphosphate
A molecular probe for the luminescent detection of adenosine
nucleotides is presented. The probe, Tb-DOTAm-Phen, readily distinguishes
among the three adenosine nucleotides in buffered aqueous conditions
at neutral pH, a requirement for the direct monitoring of enzymatic
reactions converting adenosine triphosphate (ATP) to adenosine diphosphate
or adenosine monophosphate. The probe is most efficient under millimolar
concentrations of ATP which are relevant to intracellular conditions.
Moreover, the long luminescence lifetime of the probe readily enables
time-gating experiments