INTERFACING WITH BUILDING DATA: TOWARD AN INTEGRATED MOBILE AUGMENTED ENVIRONMENT

Communications between buildings and their occupants through multimodal Human Computer Interactions (HCI) can dramatically enhance the way buildings are experienced. Although building performance data is becoming more readily available, no research has been established to enable visualization of and interaction with this information in a robust way. This paper will present a method that will allow users to visualize and interact with building performance data in real space. It extends our research efforts to enable users to visualize such data for multiroom settings by developing methods to enable such environments to become mobile and being able to communicate with readily available building data

A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome

The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial–mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcriptional investigations using reversible models of EMT, revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC). From this enrichment, a metastasis-derived gene signature was identified that predicted more rapid cancer relapse and reduced survival across multiple human carcinoma types. Additionally, the transcriptional profile of MErT is not a simple mirror image of EMT as tumour cells retain a transcriptional “memory” following a reversible EMT. This memory was also enriched in mCRPC samples. Cumulatively, our studies reveal the transcriptional profile of epithelial–mesenchymal plasticity and highlight the unique transcriptional properties of MErT. Furthermore, our findings provide evidence to support the association of epithelial plasticity with poor clinical outcomes in multiple human carcinoma types