The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress

The innate immune system’s ability to sense an infection is critical so that it can rapidly respond if pathogenic microorganisms threaten the host, but otherwise maintain a quiescent baseline state to avoid causing damage to the host or to commensal microorganisms. One important mechanism for discriminating between pathogenic and non-pathogenic bacteria is the recognition of cellular damage caused by a pathogen during the course of infection. InCaenorhabditis elegans, the conserved G-protein coupled receptor FSHR-1 is an important constituent of the innate immune response. FSHR-1 activates the expression of antimicrobial infection response genes in infected worms and delays accumulation of the ingested pathogenPseudomonas aeruginosa. FSHR-1 is central not only to the worm’s survival of infection by multiple pathogens, but also to the worm’s survival of xenobiotic cadmium and oxidative stresses. Infected worms produce reactive oxygen species to fight off the pathogens; FSHR-1 is required at the site of infection for the expression of detoxifying genes that protect the host from collateral damage caused by this defense response. Finally, the FSHR-1 pathway is important for the ability of worms to discriminate pathogenic from benign bacteria and subsequently initiate an aversive learning program that promotes selective pathogen avoidance

The Specific Globular Cluster Frequencies of Dwarf Elliptical Galaxies from the Hubble Space Telescope

The specific globular cluster frequencies (S_N) for 24 dwarf elliptical (dE) galaxies in the Virgo and Fornax Clusters and the Leo Group imaged with the Hubble Space Telescope are presented. Combining all available data, we find that for nucleated dEs --- which are spatially distributed like giant ellipticals in galaxy clusters --- S_N(dE,N)=6.5 +- 1.2 and S_N increases with M_V, while for non-nucleated dEs --- which are distributed like late-type galaxies --- S_N(dE,noN)=3.1 +- 0.5 and there is little or no trend with M_V. The S_N values for dE galaxies are thus on average significantly higher than those for late-type galaxies, which have S_N < 1. This suggests that dE galaxies are more akin to giant Es than to late-type galaxies. If there are dormant or stripped irregulars hiding among the dE population, they are likely to be among the non-nucleated dEs. Furthermore, the similarities in the properties of the globular clusters and in the spatial distributions of dE,Ns and giant Es suggest that neither galaxy mass or galaxy metallicity is responsible for high values of S_N. Instead, most metal-poor GCs may have formed in dwarf-sized fragments that merged into larger galaxies.Comment: 12 pages (uses aaspp4.sty), 2 figures, 1 table, to appear in the Astrophysical Journa

Regulation of actin cytoskeleton architecture by Eps8 and Abi1

BACKGROUND: The actin cytoskeleton participates in many fundamental processes including the regulation of cell shape, motility, and adhesion. The remodeling of the actin cytoskeleton is dependent on actin binding proteins, which organize actin filaments into specific structures that allow them to perform various specialized functions. The Eps8 family of proteins is implicated in the regulation of actin cytoskeleton remodeling during cell migration, yet the precise mechanism by which Eps8 regulates actin organization and remodeling remains elusive. RESULTS: Here, we show that Eps8 promotes the assembly of actin rich filopodia-like structures and actin cables in cultured mammalian cells and Xenopus embryos, respectively. The morphology of actin structures induced by Eps8 was modulated by interactions with Abi1, which stimulated formation of actin cables in cultured cells and star-like structures in Xenopus. The actin stars observed in Xenopus animal cap cells assembled at the apical surface of epithelial cells in a Rac-independent manner and their formation was accompanied by recruitment of N-WASP, suggesting that the Eps8/Abi1 complex is capable of regulating the localization and/or activity of actin nucleators. We also found that Eps8 recruits Dishevelled to the plasma membrane and actin filaments suggesting that Eps8 might participate in non-canonical Wnt/Polarity signaling. Consistent with this idea, mis-expression of Eps8 in dorsal regions of Xenopus embryos resulted in gastrulation defects. CONCLUSION: Together, these results suggest that Eps8 plays multiple roles in modulating actin filament organization, possibly through its interaction with distinct sets of actin regulatory complexes. Furthermore, the finding that Eps8 interacts with Dsh and induced gastrulation defects provides evidence that Eps8 might participate in non-canonical Wnt signaling to control cell movements during vertebrate development

Depression in Husbands of Breast Cancer Patients: Relationships to Coping and Social Support

PURPOSE: The purpose of the present study was to examine depression in husbands of women with breast cancer, as depression is typically as high in husbands as in patients, and impacts functioning in both. METHODS: We compared husbands of patients to husbands of women without chronic illness on depressive symptoms with the Center for Epidemiological Studies Depression Scale, social support with the Interpersonal Support Evaluation List, and coping with the Ways of Coping Questionnaire. Using the stress and coping model, we examined whether coping mediated social support and depression differently by group, as has been found in the literature. RESULTS: Husbands of patients reported higher scores on the measure of depression and lower use of problem-focused coping, while groups reported equivalent social support. Escape-avoidance coping emerged as a full mediator between social support and depression in husbands of patients, but only a partial mediator in comparison husbands. Accepting responsibility coping partially mediated social support and depression in both groups. Low social support appears particularly detrimental in husbands of patients as it is associated with ineffective coping and depression. CONCLUSIONS: Findings suggest that among husbands of patients, social support relates to depression only through its relationship with coping, indicating healthcare providers should direct attention and intervention to the coping strategies employed by husbands with low social support

Inmate Sincerity via Community Reentry

While numerous states have programs within their prisons, community reentry-to-society is a topical area of focus. These programs require little operational funding but have a direct impact on rehabilitation of inmates. Reentry often involves outside volunteers who share invaluable lessons with inmates. With the use of precious correctional resources at issue perpetually, this study is important in examining the validity of a portion of the reentry application forms used in an Arkansas state reentry program. Findings should be of use to corrections officials, researchers and those with any interest in rehabilitation

Prosthetics in the Return to Trade Work

Importance: There is a lack of research on how different prosthetics impact return to work for individuals experiencing an upper extremity amputation. Objective: This review aims to assess myoelectric and body-powered prosthetics\u27 impact on return to physically demanding work and understand which is better suited for trade work demands and productivity. Data sources: Journal articles were last searched for using the databases, EBSCO, PubMed, Sage Journals and ScienceDirect, on October 13th, 2023. Study selection and data collection: Articles meeting inclusion criteria had to be peer-reviewed journal articles written in English, published in the last seven years, participants 18 years of age or older with an upper extremity amputation using a body-powered or external powered prosthetics, while hybrid prosthetics were not included for review. Findings: The systematic review includes four Level III articles and four Level IV articles, with four good, three fair, and one poor risk of bias ratings. Articles containing body-powered prosthetics reported less complaints and greater function in physically demanding work, while myoelectric prosthetics demonstrated greater dexterity and precise quick movements that impacted return to work. Conclusion and relevance: Myoelectric prosthetics are better suited for fine motor and mentally demanding work; however, body-powered prosthetics are better for gross motor and physically demanding work

Parent identity and family-school partnerships: Animating diverse enactments for (special) education decision-making

Family-school partnerships between family members and school personnel can be successful as well as unproductive for parents who have children and youth with developmental disabilities. This qualitative study sought to capture parents’ identities as they negotiated family-school partnerships when making inclusive education decisions and discussing special education service-delivery options for their children and youth with developmental disabilities. Seventeen participants shared their personal narratives in interviews and focus groups. Data were thematically analyzed after an initial round of open-coding generated broad themes. Findings revealed the experiences parents have in partnering with schools span an identity spectrum, including: (a) victim, (b) advocate, (c) perseverer, (d) educator, (e) broker and negotiator, and (f) surrenderer. Implications for policy, practice, and research focus on parent identity and familyschool partnerships

Parents’ experiences in education decision-making for children and youth with disabilities

Families should be an active part of educational decision-making for their children and can be particularly influential in advocating for inclusion for students with intellectual and developmental disabilities. Yet, significant research has shown that parents do not feel schools effectively collaborate with them. We interviewed 19 parents of children with disabilities to investigate the ways they were included and excluded from educational decision-making, and how they decided on their children’s placement and services. Five themes emerged: parents’ exclusion from decision-making, parents’ independent efforts to shape their children’s educational services, parents’ decisions as a result of school and district factors, parents’ role changes to direct their children’s education, and discrepancies between beliefs and experiences of inclusion. Parents’ responses indicate that specific school structures and institutionalized procedures may regularly exclude parents from decision-making. Results have implications for parent-professional partnership during decision-making for students with disabilities and personnel preparation