154 research outputs found
Changes in the use of Melbourneās Medically Supervised Injecting Room (MSIR) over the COVID-19 pandemic
A century-long record of plant evolution reconstructed from a coastal marsh seed bank
Evidence is mounting that climate-driven shifts in environmental conditions can elicit organismal evolution, yet there are sparingly few long-term records that document the tempo and progression of responses, particularly for plants capable of transforming ecosystems. In this study, we āresurrectedā cohorts of a foundational coastal marsh sedge (Schoenoplectus americanus) from a time-stratified seed bank to reconstruct a century-long record of heritable variation in response to salinity exposure. Common-garden experiments revealed that S. americanus exhibits heritable variation in phenotypic traits and biomass-based measures of salinity tolerance. We found that responses to salinity exposure differed among the revived cohorts, with plants from the early 20th century exhibiting greater salinity tolerance than those from the mid to late 20th century. Fluctuations in salinity tolerance could reflect stochastic variation but a congruent record of genotypic variation points to the alternative possibility that the loss and gain in functionality are driven by selection, with comparisons to historical rainfall and paleosalinity records suggesting that selective pressures vary according to shifting estuarine conditions. Because salinity tolerance in S. americanus is tightly coupled to primary productivity and other vital ecosystem attributes, these findings indicate that organismal evolution merits further consideration as a factor shaping coastal marsh responses to climate change
Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals
Endocrine disrupting chemicals (EDCs) include organochlorine pesticides, plastics manufacturing by-products, and certain herbicides[1]. These chemicals have been shown to disrupt hormonal signaling in exposed wildlife, lab animals, and mammalian cell culture by binding to estrogen receptors (ER-Ī± and ER-Ī²) and affecting the expression of estrogen responsive genes[2,3]. Additionally, certain plant chemicals, termed phytoestrogens, are also able to bind to estrogen receptors and modulate gene expression, and as such also may be considered EDCs[4]. One example of phytoestrogen action is genistein, a phytochemical produced by soybeans, binding estrogen receptors, and changing expression of estrogen responsive genes which certain studies have linked to a lower incidence of hormonally related cancers in Japanese populations[5]. Why would plants make compounds that are able to act as estrogens in the human body? Obviously, soybeans do not intentionally produce phytoestrogens to prevent breast cancer in Japanese women
Differential responses of osteoblast lineage cells to nanotopographically-modified, microroughened titaniumealuminumevanadium alloy surfaces
Surface structural modifications at the micrometer and nanometer scales have driven improved success rates of dental and orthopaedic implants by mimicking the hierarchical structure of bone. However, how initial osteoblast-lineage cells populating an implant surface respond to different hierarchical surface topographical cues remains to be elucidated, with bone marrow mesenchymal stem cells (MSCs) or immature osteoblasts as possible initial colonizers. Here we show that in the absence of any exogenous soluble factors, osteoblastic maturation of primary human osteoblasts (HOBs) but not osteoblastic differentiation of MSCs is strongly influenced by nanostructures superimposed onto a microrough Ti6Al4V (TiAlV) alloy. The sensitivity of osteoblasts to both surface microroughness and nanostructures led to a synergistic effect on maturation and local factor production. Osteoblastic differentiation of MSCs was sensitive to TiAlV surface microroughness with respect to production of differentiation markers, but no further enhancement was found when cultured on micro/nanostructured surfaces. Superposition of nanostructures to microroughened surfaces affected final MSC numbers and enhanced production of vascular endothelial growth factor (VEGF) but the magnitude of the response was lower than for HOB cultures. Our results suggest that the differentiation state of osteoblast-lineage cells determines the recognition of surface nanostructures and subsequent cell response, which has implications for clinical evaluation of new implant surface nanomodifications.Surface structural modifications at the micrometer and nanometer scales have driven improved success rates of dental and orthopaedic implants by mimicking the hierarchical structure of bone. However, how initial osteoblast-lineage cells populating an implant surface respond to different hierarchical surface topographical cues remains to be elucidated, with bone marrow mesenchymal stem cells (MSCs) or immature osteoblasts as possible initial colonizers. Here we show that in the absence of any exogenous soluble factors, osteoblastic maturation of primary human osteoblasts (HOBs) but not osteoblastic differentiation of MSCs is strongly influenced by nanostructures superimposed onto a microrough Ti6Al4V (TiAlV) alloy. The sensitivity of osteoblasts to both surface microroughness and nanostructures led to a synergistic effect on maturation and local factor production. Osteoblastic differentiation of MSCs was sensitive to TiAlV surface microroughness with respect to production of differentiation markers, but no further enhancement was found when cultured on micro/nanostructured surfaces. Superposition of nanostructures to microroughened surfaces affected final MSC numbers and enhanced production of vascular endothelial growth factor (VEGF) but the magnitude of the response was lower than for HOB cultures. Our results suggest that the differentiation state of osteoblast-lineage cells determines the recognition of surface nanostructures and subsequent cell response, which has implications for clinical evaluation of new implant surface nanomodifications
The Grizzly, February 13, 1996
Summer Research at Ursinus ā¢ Fairley Will Not Plead Insanity ā¢ Merck Announces HIV Drug Results ā¢ Faculty Spotlight: Dr. Lynn Thelen ā¢ Joe Clark, Gospel Choir Highlight Diversity Week ā¢ Information Superhighway Control ā¢ Captain Offender ā¢ In Search of Aristotle\u27s Prime Mover ā¢ An Entirely Warped Romantic Interlude ā¢ Hey Students, Take Some Initiative! ā¢ Do You Believe in Magic? ā¢ Take it Back, Captain Jack! ā¢ Not Slick Enough ā¢ Strike up the (String) Band! ā¢ Ursinus Handles Swarthmore, 70-39 ā¢ Ursinus Edges Washington, 64-62 ā¢ Swarthmore Sweeps UC Swim Teams ā¢ Gymnasts Victorious ā¢ Bears Regain Centennial Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1374/thumbnail.jp
The Grizzly, February 27, 1996
Koestner Gives First-Hand Account of Date Rape ā¢ J-Board Charges Reimert Residents ā¢ Swastikas are Removed from Bomberger Hall ā¢ Buchanan Wins New Hampshire ā¢ The Skipped Diploma ā¢ Evolutionary Doubts ā¢ Fighting for Real Social Change ā¢ In Support of Healthier Relationships ā¢ Alan Morrison to Perform Recital ā¢ U.S.G.A. News ā¢ Faculty Spotlight: Dr. Peter Perreten ā¢ Staff Spotlight: Todd McKinney ā¢ Gymnasts End Season With a Win ā¢ Lacrosse Team Ranked 15th ā¢ Bears Compete at Indoor Championships ā¢ Lady Bears Fall in Conference Semishttps://digitalcommons.ursinus.edu/grizzlynews/1376/thumbnail.jp
Accounting for variability when resurrecting dormant propagules substantiates their use in eco-evolutionary studies
There has been a steady rise in the use of dormant propagules to study biotic responses to environmental change over time. This is particularly important for organisms that strongly mediate ecosystem processes, as changes in their traits over time can provide a unique snapshot into the structure and function of ecosystems from decades to millennia in the past. Understanding sources of bias and variation is a challenge in the field of resurrection ecology, including those that arise because often-used measurements like seed germination success are imperfect indicators of propagule viability. Using a Bayesian statistical framework, we evaluated sources of variability and tested for zero-inflation and overdispersion in data from 13 germination trials of soil-stored seeds of Schoenoplectus americanus, an ecosystem engineer in coastal salt marshes in the Chesapeake Bay. We hypothesized that these two model structures align with an ecological understanding of dormancy and revival: zero-inflation could arise due to failed germinations resulting from inviability or failed attempts to break dormancy, and overdispersion could arise by failing to measure important seed traits. A model that accounted for overdispersion, but not zero-inflation, was the best fit to our data. Tetrazolium viability tests corroborated this result: most seeds that failed to germinate did so because they were inviable, not because experimental methods failed to break their dormancy. Seed viability declined exponentially with seed age and was mediated by seed provenance and experimental conditions. Our results provide a framework for accounting for and explaining variability when estimating propagule viability from soil-stored natural archives which is a key aspect of using dormant propagules in eco-evolutionary studies
The Grizzly, April 16, 1996
Greeks Sponsor Easter Egg Hunt for Local Kids ā¢ New Members Inducted to Phi Beta Kappa ā¢ Ursinus Physics Professor to Run in Boston Marathon ā¢ Spring Service Day ā¢ What is Phi Beta Kappa? ā¢ Choir Performs Carmina Burana ā¢ The S.U.N. is Rising ā¢ Summer Fellows Program ā¢ Opinions: Environmental Wackos; Is God Weak or is God Evil?; God in the Gymnasium; An Open Letter to the Ursinus Community ā¢ proTheatre Speaks Romance Language ā¢ Colorful Olympic Poster Art Exhibition Opens at Berman ā¢ Dine & Act Fine Restaurant Night Offers Etiquette Lesson ā¢ Spotlight: Debbie Nolan, Dean of Students ā¢ Girls Send Hopkins Home with a Loss ā¢ Team Controls Own Destiny ā¢ Men\u27s Team Wins Two Straight; Women\u27s Losing Trend Continues ā¢ Knittel Wins Gettysburg Invitational ā¢ Pecovsky Wins at Shippensburg Invitational ā¢ Softball Team Keeps Winninghttps://digitalcommons.ursinus.edu/grizzlynews/1380/thumbnail.jp
An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice:A systematic review
Background: Despite global support, there remain gaps in the integration of early palliative care into cancer care. The methods of implementation whereby evidence of benefits of palliative care is translated into practice deserve attention. Aim: To identify implementation frameworks utilised in integrated palliative care in hospital-based oncology services and to describe the associated enablers and barriers to service integration. Design: Systematic review with a narrative synthesis including qualitative, mixed methods, pre-post and quasi experimental designs following the guidance by the Centre for Reviews and Dissemination (PROSPERO registration CRD42021252092). Data sources: Six databases searched in 2021: EMBASE, EMCARE, APA PsycINFO, CINAHL, Cochrane Library and Ovid MEDLINE searched in 2023. Included were qualitative or quantitative studies, in English language, involving adults >18āyears, and implementing hospital-based palliative care into cancer care. Critical appraisal tools were used to assess the quality and rigour. Results: Seven of the 16 studies explicitly cited the use of frameworks including those based on RE-AIM, Medical Research Council evaluation of complex interventions and WHO constructs of health service evaluation. Enablers included an existing supportive culture, clear introduction to the programme across services, adequate funding, human resources and identification of advocates. Barriers included a lack of communication with the patients, caregivers, physicians and palliative care team about programme goals, stigma around the term āpalliativeā, a lack of robust training, or awareness of guidelines and undefined staff roles. Conclusions: Implementation science frameworks provide a method to underpin programme development and evaluation as palliative care is integrated within the oncology setting.Farwa Rizvi, Helen Elizabeth Wilding, Nicole M Rankin, Roslyn Le Gautier, Lorna Gurren, Vijaya Sundararajan, Kylee Bellingham, Joyce Chua, Gregory B Crawford, Anna K Nowak, Brian Le, Geoff Mitchell, Sue-Anne McLachlan, Tanara Vieira Sousa, Robyn Hudson, Maarten IJzerman, Anna Collins, and Jennifer Phili
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