A history of concussions is associated with symptoms of common mental disorders in former male professional athletes across a range of sports

Objective: Recent reports suggest that exposure to repetitive concussions in sports is associated with an increased risk of symptoms of distress, anxiety and depression, sleep disturbance or substance abuse/dependence (typically referred as symptoms of common mental disorders[CMD]) and of later development of neurodegenerative disease, in particular chronic traumatic encephalopathy (CTE). The primary aim of this study was to explore the relationship between sports career-related concussions and the subsequent occurrence of symptoms of CMD among former male professional athletes retired from football (soccer), ice hockey and rugby (union). Methods: Cross-sectional analyses were performed on baseline electronic questionnaires from three prospective cohort studies among former male professional athletes retired from football (soccer), ice hockey and rugby (union). The number of confirmed concussions was examined through a single question, while symptoms of distress, anxiety and depression, sleep disturbance and adverse alcohol use were assessed using validated questionnaires. Results: From 1,957 former professional athletes contacted, a total of 576 (29%) completed the questionnaire. Of these, 23% had not incurred a concussion during their career, 34% had two or three, 18% four or five, and 11% six or more concussions. The number of sports career-related concussions was a predictor for all outcome measures (β = 0.072–0.109; P ≤ 0.040). Specifically, former professional athletes who reported a history of four or five concussions were approximately 1.5 times more likely to report symptoms of CMD, rising to a two- to five-fold increase in those reporting a history of six or more sports career-related concussions. Conclusions: These data demonstrate an association between exposure to sports concussion and subsequent risk of symptoms of CMD in former professional athletes across a range of contact sports. Further work to explore the association between sports concussion and symptoms of CMD is required; in the meanwhile, strategies for effective risk reduction and improved management appear indicated

Classification of Atlantic halibut unique sequences according to Gene Ontology (GO) category: biological process

<p><b>Copyright information:</b></p><p>Taken from "Comprehensive EST analysis of Atlantic halibut (), a commercially relevant aquaculture species"</p><p>http://www.biomedcentral.com/1471-2164/8/144</p><p>BMC Genomics 2007;8():144-144.</p><p>Published online 4 Jun 2007</p><p>PMCID:PMC1924502.</p><p></p

Classification of Atlantic halibut unique sequences according to Gene Ontology (GO) category: molecular function

<p><b>Copyright information:</b></p><p>Taken from "Comprehensive EST analysis of Atlantic halibut (), a commercially relevant aquaculture species"</p><p>http://www.biomedcentral.com/1471-2164/8/144</p><p>BMC Genomics 2007;8():144-144.</p><p>Published online 4 Jun 2007</p><p>PMCID:PMC1924502.</p><p></p

Representation of sequencing read lengths of Atlantic halibut Expressed Sequence Tags (ESTs)

<p><b>Copyright information:</b></p><p>Taken from "Comprehensive EST analysis of Atlantic halibut (), a commercially relevant aquaculture species"</p><p>http://www.biomedcentral.com/1471-2164/8/144</p><p>BMC Genomics 2007;8():144-144.</p><p>Published online 4 Jun 2007</p><p>PMCID:PMC1924502.</p><p></p> Read lengths were binned in 100 base pair (bp) increments. Most of the ESTs fall into the 700–800 bp bin

Classification of Atlantic halibut unique sequences according to Gene Ontology (GO) category: cellular component

<p><b>Copyright information:</b></p><p>Taken from "Comprehensive EST analysis of Atlantic halibut (), a commercially relevant aquaculture species"</p><p>http://www.biomedcentral.com/1471-2164/8/144</p><p>BMC Genomics 2007;8():144-144.</p><p>Published online 4 Jun 2007</p><p>PMCID:PMC1924502.</p><p></p

Additional file 12: Figure S8. of Population Dynamics Among six Major Groups of the Oryza rufipogon Species Complex, Wild Relative of Cultivated Asian Rice

Chloroplast haplotype network including admixed samples. (PDF 598 kb

Additional file 9: Figure S5. of Population Dynamics Among six Major Groups of the Oryza rufipogon Species Complex, Wild Relative of Cultivated Asian Rice

Pericarp Color Associated with RC Haplotype Groups. (PDF 253 kb

Additional file 16: of Population Dynamics Among six Major Groups of the Oryza rufipogon Species Complex, Wild Relative of Cultivated Asian Rice

Supplemental Text. Extended Materials and Methods (Additional file 18). (DOCX 21 kb