A simple principle concerning the robustness of protein complex activity to changes in gene expression-3

<p><b>Copyright information:</b></p><p>Taken from "A simple principle concerning the robustness of protein complex activity to changes in gene expression"</p><p>http://www.biomedcentral.com/1752-0509/2/1</p><p>BMC Systems Biology 2008;2():1-1.</p><p>Published online 2 Jan 2008</p><p>PMCID:PMC2242779.</p><p></p>iched amongst the subunits of protein complexes. In contrast genes with over-expression phenotypes are equally represented amongst protein complex subunits and other genes. The graph shows the percentage of genes found in MIPS protein complexes and the percentage of all other genes that have each phenotype. ** Chi square test p < 0.05 for difference between protein complex subunits and all genes

A simple principle concerning the robustness of protein complex activity to changes in gene expression-1

<p><b>Copyright information:</b></p><p>Taken from "A simple principle concerning the robustness of protein complex activity to changes in gene expression"</p><p>http://www.biomedcentral.com/1752-0509/2/1</p><p>BMC Systems Biology 2008;2():1-1.</p><p>Published online 2 Jan 2008</p><p>PMCID:PMC2242779.</p><p></p>st to an increase, but not to a decrease in the expression levels of individual subunits

A simple principle concerning the robustness of protein complex activity to changes in gene expression-2

<p><b>Copyright information:</b></p><p>Taken from "A simple principle concerning the robustness of protein complex activity to changes in gene expression"</p><p>http://www.biomedcentral.com/1752-0509/2/1</p><p>BMC Systems Biology 2008;2():1-1.</p><p>Published online 2 Jan 2008</p><p>PMCID:PMC2242779.</p><p></p>uctural components of protein complexes as defined by Gavin (2006). The percentages of all genes are shown for comparison. Inset: schematic representation of the overlap between the datasets used. Only 21 genes are found exclusively in modules, so we did not test these as a separate category. ** Fisher's exact test p < 0.0001 for difference between genes with the particular phenotype and all genes without that phenotype

A simple principle concerning the robustness of protein complex activity to changes in gene expression-0

<p><b>Copyright information:</b></p><p>Taken from "A simple principle concerning the robustness of protein complex activity to changes in gene expression"</p><p>http://www.biomedcentral.com/1752-0509/2/1</p><p>BMC Systems Biology 2008;2():1-1.</p><p>Published online 2 Jan 2008</p><p>PMCID:PMC2242779.</p><p></p>st to an increase, but not to a decrease in the expression levels of individual subunits