13 research outputs found
Novel Testimony: Alternative Archives in Edwidge Danticatâs \u3ci\u3eThe Farming of Bones\u3c/i\u3e
The Undocumented Subjects of el Hueco: Theorizing a Colombian Metaphor for Migration
This article theorizes the trope of el Hueco that Colombians use to describe crossing undocumented into the United States, colloquially referring to undocumented migration as entering âpor el Hueco,â which translates as âthrough the Hole or Gap.â I posit that el Hueco provides a fruitful new metaphor for Latina/o studies that is directly rooted in the experience of undocumented migration and in an extended geography that connects South America, Central America, Mexico, and the Caribbean. I analyze how Jorge Francoâs novel ParaĂso Travel and Kofreâs CD ÂĄPor el hueco! figure crossing through el Hueco as a form of burial, thereby symbolically capturing the death of migrantsâ legal subjectivity and of their national identities. I posit that Franco and Kofre simultaneously reconfigure restrictive notions of national affiliation by imagining affective citizenship and insurgent hemispheric belonging. Overall, the article opens up a space to consider the critical import of U.S. Colombian literary production within the field imaginary of Latina/o studies
Novel Testimony: Alternative Archives in Edwidge Danticatâs \u3ci\u3eThe Farming of Bones\u3c/i\u3e
The Undocumented Subjects of el Hueco: Theorizing a Colombian Metaphor for Migration
This article theorizes the trope of el Hueco that Colombians use to describe crossing undocumented into the United States, colloquially referring to undocumented migration as entering âpor el Hueco,â which translates as âthrough the Hole or Gap.â I posit that el Hueco provides a fruitful new metaphor for Latina/o studies that is directly rooted in the experience of undocumented migration and in an extended geography that connects South America, Central America, Mexico, and the Caribbean. I analyze how Jorge Francoâs novel ParaĂso Travel and Kofreâs CD ÂĄPor el hueco! figure crossing through el Hueco as a form of burial, thereby symbolically capturing the death of migrantsâ legal subjectivity and of their national identities. I posit that Franco and Kofre simultaneously reconfigure restrictive notions of national affiliation by imagining affective citizenship and insurgent hemispheric belonging. Overall, the article opens up a space to consider the critical import of U.S. Colombian literary production within the field imaginary of Latina/o studies
To the Border and Back: Visualizing and Narrating Migration
As part of our Migrations and Borderlands 360° course cluster, we brought the travelling photography exhibition Del Golfo al PacĂfico, which chronicles the evolution of the U.S.-Mexico border over the last three decades, to Bryn Mawr College. This exhibition was curated by El Colegio de la Frontera Norte (COLEF), a research institute in Tijuana, Mexico dedicated to studying the phenomenon of migration between the two countries. Our students used this exhibition as an analytical and artistic tool to prepare for our class trip to Tucson and Nogales, Arizona and to Tijuana. While in Mexico, we had the opportunity to do a photography workshop with Alfonso Caraveo Castro, a photographer at COLEF and one of the curators of Del Golfo al PacĂfico. We asked students to select one of the photographs they took during our trip to the border and put it in dialogue with one of the COLEF photographs, narrating what they learned about migration from this experience. Collected herein are our studentsâ images, analyses, and meditations on the U.S.-Mexico border.https://repository.brynmawr.edu/bmc_books/1032/thumbnail.jp
To the Border and Back: Visualizing and Narrating Migration
As part of our Migrations and Borderlands 360° course cluster, we brought the travelling photography exhibition Del Golfo al PacĂfico, which chronicles the evolution of the U.S.-Mexico border over the last three decades, to Bryn Mawr College. This exhibition was curated by El Colegio de la Frontera Norte (COLEF), a research institute in Tijuana, Mexico dedicated to studying the phenomenon of migration between the two countries. Our students used this exhibition as an analytical and artistic tool to prepare for our class trip to Tucson and Nogales, Arizona and to Tijuana. While in Mexico, we had the opportunity to do a photography workshop with Alfonso Caraveo Castro, a photographer at COLEF and one of the curators of Del Golfo al PacĂfico. We asked students to select one of the photographs they took during our trip to the border and put it in dialogue with one of the COLEF photographs, narrating what they learned about migration from this experience. Collected herein are our studentsâ images, analyses, and meditations on the U.S.-Mexico border.https://repository.brynmawr.edu/bmc_books/1032/thumbnail.jp
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570