1,100 research outputs found
Impact of pressure dissipation on fluid injection into layered aquifers
Carbon dioxide (CO2) capture and subsurface storage is one method for
reducing anthropogenic CO2 emissions to mitigate climate change. It is well
known that large-scale fluid injection into the subsurface leads to a buildup
in pressure that gradually spreads and dissipates through lateral and vertical
migration of water. This dissipation can have an important feedback on the
shape of the CO2 plume during injection, and the impact of vertical pressure
dissipation, in particular, remains poorly understood. Here, we investigate the
impact of lateral and vertical pressure dissipation on the injection of CO2
into a layered aquifer system. We develop a compressible, two-phase model that
couples pressure dissipation to the propagation of a CO2 gravity current. We
show that our vertically integrated, sharp-interface model is capable of
efficiently and accurately capturing water migration in a layered aquifer
system with an arbitrary number of aquifers. We identify two limiting cases ---
`no leakage' and `strong leakage' --- in which we derive analytical expressions
for the water pressure field for the corresponding single-phase injection
problem. We demonstrate that pressure dissipation acts to suppress the
formation of an advancing CO2 tongue during injection, resulting in a plume
with a reduced lateral extent. The properties of the seals and the number of
aquifers determine the strength of pressure dissipation and subsequent coupling
with the CO2 plume. The impact of pressure dissipation on the shape of the CO2
plume is likely to be important for storage efficiency and security
A homoleptic phosphine adduct of Tl(I)
A homoleptic phosphine adduct of thallium(I) supported by a tris(phosphino)borate ligand has been isolated and structurally characterized
The phospholipase iPLA2Îł is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling
The influence of spectral registration on diffusion-weighted magnetic resonance spectroscopy ADC estimates
A comparison of analytical techniques and the products formed during the decomposition of biodiesel under accelerated conditions
Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore
Fixed lateral unicompartmental knee replacement is a reliable treatment for lateral compartment osteoarthritis after mobile-bearing medial unicompartmental replacement
Purpose:Â Lateral osteoarthritis following medial unicompartmental knee replacement (UKR) is usually treated with total knee replacement, however, lateral UKR is a less invasive option that preserves a well-functioning medial UKR. This study aimed to determine the 5-year outcome of the cemented Fixed Lateral Oxford UKR (FLO) when used for the treatment of severe lateral disease after medial Oxford unicompartmental knee replacement.
Methods: Forty-four knees with lateral bone-on-bone osteoarthritis (n = 43) and avascular necrosis (n = 1) treated with the FLO following medial Oxford UKR were followed up prospectively. The Oxford Knee Score (OKS) and Tegner Activity Score (TAS) were collected pre- and post-operatively. Life-table analysis was used to determine survival rates.
Results: The mean patient age at the time of FLO surgery was 74.4 years with a mean time of 12.1 years between the primary medial UKR and the conversion to a bi-UKR with a FLO. Mean follow-up of the FLO was 3.5 years. After FLO no intra-operative or medical complications, re-admissions, or mortality occurred. There was one reoperation in which a bearing was exchanged for a medial bearing dislocation. There were no revisions of the FLO, so the FLO survival rate at 5 years was 100% (24 at risk). The mean pre-operative OKS was 22, which significantly (p < 0.0001) improved to a mean of 42, 42, and 40 at 1, 2, and 5 years, respectively. The median TAS had a non-significant improvement from 2.5 (Range 0–8) pre-operatively to 2 (Range 1–6) at 5 years postoperatively.
Conclusion:Â The FLO is a reliable treatment for lateral osteoarthritis following medial UKR. At 5Â years there was a 100% survival of the FLO with a mean OKS of 40.
Level of evidence:Â IV, Prospective Case Series
Cytochrome c is an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl ether linkage
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2Îł knockout
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