1,489 research outputs found
Formulating a Strategy for Securing High-Speed Rail in the United States, Research Report 12-03
This report presents an analysis of information relating to attacks, attempted attacks, and plots against high-speed rail (HSR) systems. It draws upon empirical data from MTI’s Database of Terrorist and Serious Criminal Attacks Against Public Surface Transportation and from reviews of selected HSR systems, including onsite observations. The report also examines the history of safety accidents and other HSR incidents that resulted in fatalities, injuries, or extensive asset damage to examine the inherent vulnerabilities (and strengths) of HSR systems and how these might affect the consequences of terrorist attacks. The study is divided into three parts: (1) an examination of security principles and measures; (2) an empirical examination of 33 attacks against HSR targets and a comparison of attacks against HSR targets with those against non-HSR targets; and (3) an examination of 73 safety incidents on 12 HRS systems. The purpose of this study is to develop an overall strategy for HSR security and to identify measures that could be applied to HSR systems currently under development in the United States. It is hoped that the report will provide useful guidance to both governmental authorities and transportation operators of current and future HSR systems
A homoleptic phosphine adduct of Tl(I)
A homoleptic phosphine adduct of thallium(I) supported by a tris(phosphino)borate ligand has been isolated and structurally characterized
Decays of Baryons --- Quark Model versus Large-
We study nonleptonic decays of the orbitally excited, \su6 \rep{70}-plet
baryons in order to test the hypothesis that the successes of the
nonrelativistic quark model have a natural explanation in the large- limit
of QCD. By working in a Hartree approximation, we isolate a specific set of
operators that contribute to the observed s- and d-wave decays in leading order
in . We fit our results to the current experimental decay data, and make
predictions for a number of allowed but unobserved modes. Our tentative
conclusion is that there is more to the nonrelativistic quark model of baryons
than large-.Comment: LaTeX 49pp. (38 pp. landscape), PicTex, PrePicTex, PostPicTex
required for 3 figures, Harvard Preprint HUTP-94/A008. (Two additional
operators are included, but conclusions are unchanged.
Measuring Transit Signal Recovery in the Kepler Pipeline. III. Completeness of the Q1-Q17 DR24 Planet Candidate Catalogue, with Important Caveats for Occurrence Rate Calculations
With each new version of the Kepler pipeline and resulting planet candidate
catalogue, an updated measurement of the underlying planet population can only
be recovered with an corresponding measurement of the Kepler pipeline detection
efficiency. Here, we present measurements of the sensitivity of the pipeline
(version 9.2) used to generate the Q1-Q17 DR24 planet candidate catalog
(Coughlin et al. 2016). We measure this by injecting simulated transiting
planets into the pixel-level data of 159,013 targets across the entire Kepler
focal plane, and examining the recovery rate. Unlike previous versions of the
Kepler pipeline, we find a strong period dependence in the measured detection
efficiency, with longer (>40 day) periods having a significantly lower
detectability than shorter periods, introduced in part by an incorrectly
implemented veto. Consequently, the sensitivity of the 9.2 pipeline cannot be
cast as a simple one-dimensional function of the signal strength of the
candidate planet signal as was possible for previous versions of the pipeline.
We report on the implications for occurrence rate calculations based on the
Q1-Q17 DR24 planet candidate catalog and offer important caveats and
recommendations for performing such calculations. As before, we make available
the entire table of injected planet parameters and whether they were recovered
by the pipeline, enabling readers to derive the pipeline detection sensitivity
in the planet and/or stellar parameter space of their choice.Comment: 8 pages, 5 figures, full electronic version of Table 1 available at
the NASA Exoplanet Archive; accepted by ApJ May 2nd, 201
The deep distributions of helium isotopes, radiocarbon, and noble gases along the U.S. GEOTRACES East Pacific Zonal Transect (GP16)
Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Marine Chemistry 201 (2018): 167-182, doi:10.1016/j.marchem.2017.03.009.We report the deep distributions of noble gases, helium isotopes, and radiocarbon measured during the U.S. GEOTRACES GP16 East Pacific Zonal Transect between 152 and 77°W at 12- 15°S in the South Pacific. The dominant feature is an intense tongue of hydrothermal effluent that extends more than 4,000 km westward from the East Pacific Rise (EPR) at ~2500m depth. The patterns reveal significant “downstream” variations in water mass structure, advection, and mixing that belie the simple perception of a continuous plume extending westward from the EPR. For example, one feature observed at 120°W, 14°S has tracer signatures that are consistent with a water mass originating from an area as much as 2,000 km south of this section, suggesting a quasi-permanent northward flow on the western flank of the EPR. Helium isotope variations in the plume show a uniquely high 3He/4He source in the tongue compared with typical mid-ocean ridge basalts (MORB), consistent with the anomalously high ratios observed in MORB glasses from the EPR segment just south of this transect. The water column data also reveal that the background 3He/4He east of the EPR is significantly lower than values characteristic of MORB, suggesting an additional, more geographically distributed radiogenic 4He flux of order 107 mol/y into the deep Pacific.
In the western end of the section, incoming bottom waters have relatively less hydrothermal hydrothermal helium, more radiocarbon, and more oxygen, as well as negative saturation anomalies for the heavy noble gases (Ar, Kr, and Xe). During the basin-scale upwelling of this water, diapycnal mixing serves to erase these negative anomalies. The relative magnitudes of the increases for the heavy noble gases (Ar, Kr, and Xe) are quantitatively consistent with this process. This leads us to estimate the relatively smaller effects on He and Ne saturations, which range from near zero to 0.2% and 0.3% respectively. With this information, we are able to refine our estimates of the magnitude of 3He and 4He excesses and the absolute 3He/4He ratio of non-atmospheric helium introduced into deep Pacific waters.The work was funded under National Science Foundation grant number OCE-1232991 for WJJ and OCE-1130870 for CRG
Healthcare resource utilization and related financial costs associated with glucose lowering with either exenatide or basal insulin: a retrospective cohort study
Aims
Type 2 diabetes is a major health problem placing increasing demands on healthcare systems. Our objective was to estimate healthcare resource use and related financial costs following treatment with exenatide‐based regimens prescribed as once‐weekly (EQW) or twice‐daily (EBID) formulations, compared with regimens based on basal insulin (BI).
Materials and methods
This retrospective cohort study used data from the UK Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES). Patients with type 2 diabetes who received exenatide or BI between 2009 and 2014 as their first recorded exposure to injectable therapy were selected. Costs were attributed to primary care contacts, diabetes‐related prescriptions and inpatient admissions using standard UK healthcare costing methods (2014 prices). Frequency and costs were compared between cohorts before and after matching by propensity score using Poisson regression.
Results
Groups of 8723, 218 and 2180 patients receiving BI, EQW and EBID, respectively, were identified; 188 and 1486 patients receiving EQW and EBID, respectively, were matched 1:1 to patients receiving BI by propensity score. Among unmatched cohorts, total crude mean costs per patient‐year were £2765 for EQW, £2549 for EBID and £4080 for BI. Compared with BI, the adjusted annual cost ratio (aACR) was 0.92 (95% CI, 0.91‐0.92) for EQW and 0.82 (95% CI, 0.82‐0.82) for EBID. Corresponding costs for the propensity‐matched subgroups were £2646 vs £3283 (aACR, 0.80, 0.80‐0.81) for EQW vs BI and £2532 vs £3070 (aACR, 0.84, 0.84‐0.84) for EBID vs BI.
Conclusion
Overall, exenatide once‐weekly and twice‐daily‐based regimens were associated with reduced healthcare resource use and costs compared with basal‐insulin‐based regimens
Detection of Potential Transit Signals in the First Three Quarters of Kepler Mission Data
We present the results of a search for potential transit signals in the first
three quarters of photometry data acquired by the Kepler Mission. The targets
of the search include 151,722 stars which were observed over the full interval
and an additional 19,132 stars which were observed for only 1 or 2 quarters.
From this set of targets we find a total of 5,392 detections which meet the
Kepler detection criteria: those criteria are periodicity of the signal, an
acceptable signal-to-noise ratio, and a composition test which rejects spurious
detections which contain non-physical combinations of events. The detected
signals are dominated by events with relatively low signal-to-noise ratio and
by events with relatively short periods. The distribution of estimated transit
depths appears to peak in the range between 40 and 100 parts per million, with
a few detections down to fewer than 10 parts per million. The detected signals
are compared to a set of known transit events in the Kepler field of view which
were derived by a different method using a longer data interval; the comparison
shows that the current search correctly identified 88.1% of the known events. A
tabulation of the detected transit signals, examples which illustrate the
analysis and detection process, a discussion of future plans and open,
potentially fruitful, areas of further research are included
Measuring Transit Signal Recovery in the Kepler Pipeline II: Detection Efficiency as Calculated in One Year of Data
The Kepler planet sample can only be used to reconstruct the underlying
planet occurrence rate if the detection efficiency of the Kepler pipeline is
known, here we present the results of a second experiment aimed at
characterising this detection efficiency. We inject simulated transiting planet
signals into the pixel data of ~10,000 targets, spanning one year of
observations, and process the pixels as normal. We compare the set of
detections made by the pipeline with the expectation from the set of simulated
planets, and construct a sensitivity curve of signal recovery as a function of
the signal-to-noise of the simulated transit signal train. The sensitivity
curve does not meet the hypothetical maximum detection efficiency, however it
is not as pessimistic as some of the published estimates of the detection
efficiency. For the FGK stars in our sample, the sensitivity curve is well fit
by a gamma function with the coefficients a = 4.35 and b = 1.05. We also find
that the pipeline algorithms recover the depths and periods of the injected
signals with very high fidelity, especially for periods longer than 10 days. We
perform a simplified occurrence rate calculation using the measured detection
efficiency compared to previous assumptions of the detection efficiency found
in the literature to demonstrate the systematic error introduced into the
resulting occurrence rates. The discrepancies in the calculated occurrence
rates may go some way towards reconciling some of the inconsistencies found in
the literature.Comment: 13 pages, 7 figures, 1 electronic table, accepted by Ap
Detection of Potential Transit Signals in Sixteen Quarters of Kepler Mission Data
We present the results of a search for potential transit signals in four
years of photometry data acquired by the Kepler Mission. The targets of the
search include 111,800 stars which were observed for the entire interval and
85,522 stars which were observed for a subset of the interval. We found that
9,743 targets contained at least one signal consistent with the signature of a
transiting or eclipsing object, where the criteria for detection are
periodicity of the detected transits, adequate signal-to-noise ratio, and
acceptance by a number of tests which reject false positive detections. When
targets that had produced a signal were searched repeatedly, an additional
6,542 signals were detected on 3,223 target stars, for a total of 16,285
potential detections. Comparison of the set of detected signals with a set of
known and vetted transit events in the Kepler field of view shows that the
recovery rate for these signals is 96.9%. The ensemble properties of the
detected signals are reviewed.Comment: Accepted by ApJ Supplemen
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