Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Intangible Benefactors and the Contribution of Construal Level and Attitude Accessibility in Predicting Gratitude and Expansive Emotions

We tested whether manipulating construal level would change the experience of gratitude or other expansive emotions (gratitude, awe, compassion) and negative emotions. We also examined whether construal level was correlated with the type of gratitude benefactor that participants spontaneously listed, focusing especially on God and non-theistic intangible benefactors compared to tangible human benefactors. We manipulated construal level in 265 U.S.-based CloudResearch participants to test preregistered hypotheses that high-level construals would elicit more examples of gratitude toward intangible benefactors and increase expansive emotions. We conducted additional exploratory analyses, investigating whether attitude accessibility of God as a benefactor was correlated with increases in expansive emotions. High construal level manipulation was associated with more frequently listing non-theistic intangible benefactors. Further, trait construal level predicted expansive emotions. Additionally, attitude accessibility of God as a benefactor was positively related to expansive emotions. We discuss future research possibilities to differentiate between gratitude toward tangible and intangible benefactors and the use of attitude accessibility as an implicit measure of benefactor importance