Rod i siromaštvo: Pristup žena i devojčica socijalnim uslugama u ruralnim područjima Srbije

Ovo je rad o rodnim aspektima siromaštva, baziran na trodelnom istraživanju koje se sprovodi na teritoriji Srbije, od 2014-e do 2016-e godine: pregledna analiza legislativnog i funkcionalnog okvira delovanja institucija koje pružaju različite usluge socijalne zaštite i dve grupe strukturisanih intervjua sa etnografskim elementima sa pružaocima i primaocima usluga socijalne zaštite iz ruralnih oblasti. Akcioni element istraživanja predstavlja osnovu za reformske aktivnosti usmerene ka sistemu socijalne zaštite kojima bi se učinio napredak u ovoj oblasti. Nevladine i državne organizacije koje se bave socijalnom zaštitom posluju u situaciji nezavršene tranzicije iz državno kontrolisanog sistema socijalne zaštite u sistem malih pojedinačnih ponuđača usluga socijalne podrške koji se nadmeću na tržištu. Prikazaćemo deo socio-političkog i pravnog okvira u kojima ove organizacije posluju, kao i situaciju na terenu iz ugla predstavnika/ca organizacija

Defining the genetic control of human blood plasma N-glycome using genome-wide association study

Glycosylation is a common post-translational modification of proteins. Glycosylation is associated with a number of human diseases. Defining genetic factors altering glycosylation may provide a basis for novel approaches to diagnostic and pharmaceutical applications. Here we report a genome-wide association study of the human blood plasma N-glycome composition in up to 3811 people measured by Ultra Performance Liquid Chromatography (UPLC) technology. Starting with the 36 original traits measured by UPLC, we computed an additional 77 derived traits leading to a total of 113 glycan traits. We studied associations between these traits and genetic polymorphisms located on human autosomes. We discovered and replicated 12 loci. This allowed us to demonstrate an overlap in genetic control between total plasma protein and IgG glycosylation. The majority of revealed loci contained genes that encode enzymes directly involved in glycosylation (FUT3/FUT6, FUT8, B3GAT1, ST6GAL1, B4GALT1, ST3GAL4, MGAT3 and MGAT5) and a known regulator of plasma protein fucosylation (HNF1A). However, we also found loci that could possibly reflect other more complex aspects of glycosylation process. Functional genomic annotation suggested the role of several genes including DERL3, CHCHD10, TMEM121, IGH and IKZF1. The hypotheses we generated may serve as a starting point for further functional studies in this research area

Rod i siromaštvo: Pristup žena i devojčica socijalnim uslugama u ruralnim područjima Srbije

Ovo je rad o rodnim aspektima siromaštva, baziran na trodelnom istraživanju koje se sprovodi na teritoriji Srbije, od 2014-e do 2016-e godine: pregledna analiza legislativnog i funkcionalnog okvira delovanja institucija koje pružaju različite usluge socijalne zaštite i dve grupe strukturisanih intervjua sa etnografskim elementima sa pružaocima i primaocima usluga socijalne zaštite iz ruralnih oblasti. Akcioni element istraživanja predstavlja osnovu za reformske aktivnosti usmerene ka sistemu socijalne zaštite kojima bi se učinio napredak u ovoj oblasti. Nevladine i državne organizacije koje se bave socijalnom zaštitom posluju u situaciji nezavršene tranzicije iz državno kontrolisanog sistema socijalne zaštite u sistem malih pojedinačnih ponuđača usluga socijalne podrške koji se nadmeću na tržištu. Prikazaćemo deo socio-političkog i pravnog okvira u kojima ove organizacije posluju, kao i situaciju na terenu iz ugla predstavnika/ca organizacija

Application of Silicone in Ophthalmology: A Review

This paper reviews the latest trends and applications of silicone in ophthalmology, especially related to intraocular lenses (IOLs). Silicone, or siloxane elastomer, as a synthetic polymer, has excellent biocompatibility, high chemical inertness, and hydrophobicity, enabling wide biomedical applications. The physicochemical properties of silicone are reviewed. A review of methods for mechanical and in vivo characterization of IOLs is presented as a prospective research area, since there are only a few available technologies, even though these properties are vital to ensure medical safety and suitability for clinical use, especially if long-term function is considered. IOLs represent permanent implants to replace the natural lens or for correcting vision, with the first commercial foldable lens made of silicone. Biological aspects of posterior capsular opacification have been reviewed, including the effects of the implanted silicone IOL. However, certain issues with silicone IOLs are still challenging and some conditions can prevent its application in all patients. The latest trends in nanotechnology solutions have been reviewed. Surface modifications of silicone IOLs are an efficient approach to further improve biocompatibility or to enable drug-eluting function. Different surface modifications, including coatings, can provide long-term treatments for various medical conditions or medical diagnoses through the incorporation of sensory functions. It is essential that IOL optical characteristics remain unchanged in case of drug incorporation and the application of nanoparticles can enable it. However, clinical trials related to these advanced technologies are still missing, thus preventing their clinical applications at this moment