155 research outputs found
Ecological characterization of the Florida springs coast: Pithlachascotee to Waccasassa Rivers
This report covers the upper coast of west-central Florida. This region includes the drainage basins and nearshore waters of the west coast of Florida between, but not including, the Anclote River basin and the Suwannee River basin. The name Springs Coast wash chosen because this area contains a multitude of springs, both named and too small or inaccessible to have been names. Much of the area is karstic limestone. Most recognizable among the springs are the famous Crystal river, Weeki Wachee, and Homosassa. This territory includes large expanses of
marsh and wetland and, along its shores, the southern end of the largest area of seagrass beds in the state -- the Florida Big Bend Seagrass Beds preserve. It also possesses numerous spring-fed rivers and streams along the coast, whose constant discharges provide unique, relatively stable estuarine environments. This document is a summary of the available
information on the Springs Coast area of Florida, for
use by planners, developers, regulatory authorities,
and other interested parties. An understanding of the
factors affecting their plans and the possibly unexpected
impacts of their actions on others will, it is
hoped, promote intelligent development in areas
capable of supporting it. We have tried to provide a
clear, coherent picture of what is currently known
about how the physical, chemical, and biological
factors of the environment interact. (343 pp.
Rho iso-alpha acids from hops inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation
<p>Abstract</p> <p>Background</p> <p><it>Rho </it>iso-alpha acids (RIAA) from hops have been shown to have anti-inflammatory properties. To understand the mechanisms, we evaluated the effect of RIAA in cell signaling pathways and inflammatory markers using various in vitro models. We also investigated their therapeutic effect in mice with collagen-induced arthritis.</p> <p>Methods</p> <p>The LPS-stimulated RAW 264.7 macrophages were used to evaluate the effect of RIAA on the NF-κB and MAPK signaling pathways; phosphorylation of ERK1/2, p38 and JNK was assessed by western blotting and NF-κB binding by electrophoretic mobility shift assays. Effect on the NF-κB activity was evaluated by the luciferase reporter assays in LPS-stimulated RAW 264.7 cells. GSK-3α/β kinase activity was measured in cell-free assays. The inhibitory effect of RIAA on inflammatory markers was assessed by measuring nitric oxide in LPS-stimulated RAW 264.7 cells, RANKL-mediated TRAP activity in transformed osteoclasts, and TNF-α/IL-1β-mediated MMP-13 expression in SW1353 cells. Mice with collagen-induced arthritis were fed with RIAA for 2 weeks. Symptoms of joint swelling, arthritic index and joint damage were assessed.</p> <p>Results</p> <p>RIAA selectively inhibited the NF-κB pathway while having no effect on ERK1/2, p38 and JNK phosphorylation in LPS-stimulated RAW 264.7 cells. RIAA also inhibited GSK-3α/β kinase activity and GSK-3β dependent phosphorylation of β-catenin in RAW 264.7 cells. In addition, RIAA inhibited NF-κB-mediated inflammatory markers in various cell models, including nitric oxide in LPS-stimulated RAW 264.7 cells, RANKL-mediated TRAP activity in transformed osteoclasts, and TNF-α/IL-1β-mediated MMP-13 expression in SW1353 human chondrosarcoma cells. Finally, in a mouse model of collagen-induced arthritis, RIAA ameliorated joint damage as evidenced by significant reduction of the arthritis index and histology score; at 250 mg/kg-body weight, RIAA had efficacy similar to that of 20 mg/kg-body weight of celecoxib.</p> <p>Conclusion</p> <p>RIAA may have potential as an anti-inflammatory therapeutic.</p
Cosmic Star Formation History to z=1 from a Narrow Emission Line Selected Tunable Filter Survey
We report the results of a deep 3D imaging survey of the Hubble Deep Field
North using the Taurus Tunable Filter and the William Herschel Telescope. This
survey was designed to search for new line emitting populations of objects
missed by other techniques and to measure the cosmic star-formation rate
density from a line-selected survey. We observed in three contiguous sequences
of narrow band slices in the 7100, 8100 and 9100A regions of the spectrum,
corresponding to a cosmological volume of up to 1000 Mpc^3 at z=1, down to a
flux limit of 2x 10^-17 ergs cm^-2 s^-1. The survey is deep enough to be highly
complete for low line luminosity galaxies. Cross-matching with existing
spectroscopy in the field results in a small line-luminosity limited sample,
with very highly redshift identification completeness containing seven [OII],
Hbeta and Halpha emitters over the redshift range 0.3 - 0.9. Treating this as a
direct star-formation rate selected sample we estimate the star-formation
history of the Universe to z=1. We find no evidence for any new population of
line emitting objects contributing significantly to the cosmological
star-formation rate density. Rather from our complete narrow-band sample we
find the star-formation history is consistent with earlier estimates from
broad-band imaging surveys and other less deep line-selected surveys.Comment: 12 pages, 3 figures. ApJ in press (Dec 2004
Effects of KDT501 on Metabolic Parameters in Insulin-Resistant Prediabetic Humans
Context: KDT501 is an isohumulone drug that has demonstrated beneficial effects on metabolic parameters in mice.
Objective: This study was intended to examine potential improvements in metabolism in humans.
Design and Setting: Changes in carbohydrate and lipid metabolism, along with inflammatory markers, were evaluated in prediabetic humans in a clinical research center.
Participants: Nine obese patients participated. All had prediabetes or normal glucose tolerance plus three features of metabolic syndrome.
Intervention: All participants were treated with escalating doses of KDT501 to a maximum dose of 1000 mg every 12 hours for a total of 28 days.
Outcome Measures: Changes in carbohydrate metabolism were measured with oral glucose tolerance, homeostatic model of insulin resistance, and euglycemic clamp; changes in plasma lipids and response to a lipid tolerance test; and changes in plasma inflammatory markers.
Results: The drug was well tolerated. After KDT501 treatment, plasma triglycerides were reduced at 4 hours during a lipid tolerance test. Furthermore, plasma adiponectin and high-molecular-weight adiponectin increased significantly, and plasma tumor necrosis factor-α decreased significantly. There were no significant changes in oral glucose tolerance test results or insulin sensitivity measures.
Conclusions: Despite the small sample size and the short duration of therapy, KDT501 administration reduced measures of systemic inflammation and improved postmeal plasma triglyceride levels, which may be beneficial in participants with insulin resistance or metabolic syndrome
Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome
The plant-based compounds rho-iso-alpha acids (RIAA) from Humulus lupulus (hops) and proanthocyanidins (PAC) from Acacia nilotica have been shown to modulate insulin signaling in vitro. We investigated their effects on triglyceride (TG) deposition in 3T3-L1 adipocytes, glucose and insulin in obese mouse models, and metabolic syndrome markers in adults with metabolic syndrome. The combination of RIAA and PAC synergistically increased TG content and adiponectin secretion in 3T3-L1 adipocytes under hyperinsulinemic conditions and reduced glucose or insulin in obese mice. In a clinical trial, tablets containing 100 mg RIAA and 500 mg PAC or placebo were administered to metabolic syndrome subjects (3 tablets/day, n = 35; 6 tablets/day, n = 34; or placebo, n = 35) for 12 weeks. Compared to placebo, subjects taking 3 tablets daily showed greater reductions in TG, TG : HDL, fasting insulin, and HOMA scores. The combination of RIAA : PAC at 1 : 5 (wt : wt) favorably modulates dysregulated lipids in insulin resistance and metabolic syndrome
The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans
Objective: In a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whether KDT501 increased adiponectin secretion from subcutaneous white adipose tissue (SC WAT) and the underlying mechanism(s).
Methods: Nine obese participants with either prediabetes or with normal glucose tolerance plus three features of metabolic syndrome were part of the study. SC WAT biopsies were performed before and after 28 days of KDT501 treatment in a clinical research setting. In addition, a cold stimulus was used to induce thermogenic gene expression. Adiponectin secretion was measured, and gene expression of 130 genes involved in adipose tissue function was determined. The effect of KDT501 on adipocyte mitochondrial function was analyzed in vitro.
Results: SC WAT explants secreted more total and HMW adiponectin after KDT501 treatment (P \u3c 0.05). After KDT501 treatment, a number of genes involved in thermogenesis and lipolysis were induced by cold (P \u3c 0.05). KDT501 also potentiated β-adrenergic signaling (P \u3c 0.001) and enhanced mitochondrial function in adipocytes (P \u3c 0.001).
Conclusion: KDT501 induced adiponectin secretion posttranscriptionally and increased gene expression of thermogenic and lipolytic genes in response to cold stimulation. These beneficial effects on SC WAT may be explained by the ability of KDT501 to potentiate β-adrenergic signaling and enhance mitochondrial function in adipocytes.
Clinical Trial Registration: https://www.ClinicalTrials.gov, ID number: NCT02444910
Bayes and health care research.
Bayes’ rule shows how one might rationally change one’s beliefs in the light of evidence. It is the foundation of a statistical method called Bayesianism. In health care research, Bayesianism has its advocates but the dominant statistical method is frequentism.
There are at least two important philosophical differences between these methods. First, Bayesianism takes a subjectivist view of probability (i.e. that probability scores are statements of subjective belief, not objective fact) whilst frequentism takes an objectivist view. Second, Bayesianism is explicitly inductive (i.e. it shows how we may induce views about the world based on partial data from it) whereas frequentism is at least compatible with non-inductive views of scientific method, particularly the critical realism of Popper.
Popper and others detail significant problems with induction. Frequentism’s apparent ability to avoid these, plus its ability to give a seemingly more scientific and objective take on probability, lies behind its philosophical appeal to health care researchers.
However, there are also significant problems with frequentism, particularly its inability to assign probability scores to single events. Popper thus proposed an alternative objectivist view of probability, called propensity theory, which he allies to a theory of corroboration; but this too has significant problems, in particular, it may not successfully avoid induction. If this is so then Bayesianism might be philosophically the strongest of the statistical approaches. The article sets out a number of its philosophical and methodological attractions. Finally, it outlines a way in which critical realism and Bayesianism might work together.
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Signature of a massive rotating metal-poor star imprinted in the Phoenix stellar stream*
The Phoenix stellar stream has a low intrinsic dispersion in velocity and
metallicity that implies the progenitor was probably a low mass globular
cluster. In this work we use Magellan/MIKE high-dispersion spectroscopy of
eight Phoenix stream red giants to confirm this scenario. In particular, we
find negligible intrinsic scatter in metallicity () and a large peak-to-peak range in [Na/Fe] and [Al/Fe]
abundance ratios, consistent with the light element abundance patterns seen in
the most metal-poor globular clusters. However, unlike any other globular
cluster, we also find an intrinsic spread in [Sr II/Fe] spanning 1 dex,
while [Ba II/Fe] shows nearly no intrinsic spread (). This abundance signature is best interpreted as
slow neutron capture element production from a massive fast-rotating metal-poor
star (, ,
). The low inferred cluster mass suggests the system
would have been unable to retain supernovae ejecta, implying that any massive
fast-rotating metal-poor star that enriched the interstellar medium must have
formed and evolved before the globular cluster formed. Neutron capture element
production from asymptotic giant branch stars or magneto-rotational
instabilities in core-collapse supernovae provide poor fits to the
observations. We also report one Phoenix stream star to be a lithium-rich giant
(). At it is among the
most metal-poor lithium-rich giants known.Comment: Accepted to ApJ 2021-07-0
Optical Spectra of SNR Candidates in NGC 300
We present moderate-resolution (<5A) long-slit optical spectra of 51 nebular
objects in the nearby Sculptor Group galaxy NGC 300 obtained with the 2.3 meter
Advanced Technology Telescope at Siding Spring Observatory, Australia. Adopting
the criterion of [SII]/Ha>=0.4 to confirm supernova remnants (SNRs) from
optical spectra, we find that of 28 objects previously proposed as SNRs from
optical observations, 22 meet this criterion with six showing [SII]/Ha of less
than 0.4. Of 27 objects suggested as SNRs from radio data, four are associated
with the 28 previously proposed SNRs. Of these four, three (included in the 22
above) meet the criterion. In all, 22 of the 51 nebular objects meet the
[SII]/Ha criterion as SNRs while the nature of the remaining 29 objects remains
undetermined by these observations.Comment: Accepted for publication in Astrophysics & Space Scienc
Broken into Pieces::ATLAS and Aliqa Uma as One Single Stream
We present the first spectroscopic measurements of the ATLAS and Aliqa Uma
streams from the Southern Stellar Stream Spectroscopic Survey (), in
combination with the photometric data from the Dark Energy Survey and
astrometric data from . From the coherence of spectroscopic members in
radial velocity and proper motion, we find out that these two systems are
extremely likely to be one stream with discontinuity in morphology and density
on the sky (the "kink" feature). We refer to this entire stream as the
ATLAS-Aliqa Uma stream, or the AAU stream. We perform a comprehensive
exploration of the effect of baryonic substructures and find that only an
encounter with the Sagittarius dwarf Gyr ago can create a feature
similar to the observed "kink". In addition, we also identify two gaps in the
ATLAS component associated with the broadening in the stream width (the
"broadening" feature). These gaps have likely been created by small mass
perturbers, such as dark matter halos, as the AAU stream is the most distant
cold stream known with severe variations in both the stream surface density and
the stream track on the sky. With the stream track, stream distance and
kinematic information, we determine the orbit of the AAU stream and find that
it has been affected by the Large Magellanic Cloud, resulting in a misalignment
between the proper motion and stream track. Together with the Orphan-Chenab
Stream, AAU is the second stream pair that has been found to be a single stream
separated into two segments by external perturbation.Comment: 33 pages, 22 figures (including 1 movie), 3 tables. Accepted for
publication in Ap
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