Wait For It! A Twin Study of Inhibitory Control in Early Childhood

Abstract Inhibitory control (IC) is a dimension of child temperament that emerges in toddlerhood and involves the ability to regulate behavior in response to instructions or expectations. In general, children with low levels of IC have more cognitive and social difficulties, and higher levels of problem behaviors. Unfortunately, there is a paucity of research on the heritability of this important behavioral dimension. The present study used a twin design to examine the extent to which genetic and environmental factors contribute to individual differences in IC. Laboratory and parent assessments of IC were conducted on 294 same-sex twin pairs (133 MZ, 161 DZ) at 24 months of age. Model-fitting analyses showed that genetic factors accounted for 38 and 58% of the variance in laboratoryand parent-rated IC, respectively. Multivariate genetic analyses also revealed that the covariance between observed and parent-assessed IC could be predominantly explained by common genetic influences

Behavioral inhibition in childhood: European Portuguese adaptation of an observational measure (Lab-TAB)

The assessment of behaviorally inhibited children is typically based on parent or teacher reports, but this approach has received criticisms, mainly for being prone to bias. Several researchers proposed the additional use of observational methods because they provide a direct and more objective description of the child's functioning in different contexts. The lack of a laboratory assessment of temperament for Portuguese children justifies the adaptation of some episodes of the Laboratory Temperament Assessment Battery (Lab-TAB) as an observational measure for behavioral inhibition. Method: In our study, we included 124 children aged between 3 and 9 years and their parents. The evaluation of child behavioral inhibition was made by parent report (Behavioral Inhibition Questionnaire) and through Lab-TAB episodes. Parental variables with potential influence on parents’ reports were also collected using the Social Interaction and Performance Anxiety and Avoidance Scale (SIPAAS) and the Parental Overprotection Measure (POM). Results and Discussion: The psychometric analyses provided evidence that Lab-TAB is a reliable instrument and can be incorporated in a multi-method approach to assess behavioral inhibition in studies involving Portuguese-speaking children. Moderate convergence between observational and parent report measures of behavioral inhibition was obtained. Mothers’ characteristics, as well as child age, seem to significantly affect differences between measures, being potential sources of bias in the assessment of child temperament.SFRH/BD/112728/2015info:eu-repo/semantics/publishedVersio

Evaluation of ECHO PS Positioning System in a Porcine Model of Simulated Laparoscopic Ventral Hernia Repair

Purpose. Operative efficiency improvements for laparoscopic ventral hernia repair (LVHR) have focused on reducing operative time while maintaining overall repair efficacy. Our objective was to evaluate procedure time and positioning accuracy of an inflatable mesh positioning device (Echo PS Positioning System), as compared to a standard transfascial suture technique, using a porcine model of simulated LVHR. Methods. The study population consisted of seventeen general surgeons (n = 17) that performed simulated LVHR on seventeen (n = 17) female Yorkshire pigs using two implantation techniques: (1) Ventralight ST Mesh + Echo PS Positioning System (Echo PS) and (2) Ventralight ST Mesh + transfascial sutures (TSs). Procedure time and mesh centering accuracy overtop of a simulated surgical defect were evaluated. Results. Echo PS demonstrated a 38.9% reduction in the overall procedure time, as compared to TS. During mesh preparation and positioning, Echo PS demonstrated a 60.5% reduction in procedure time (P \u3c 0.0001). Although a trend toward improved centering accuracy was observed for Echo PS (16.2%), this was not significantly different than TS. Conclusions. Echo PS demonstrated a significant reduction in overall simulated LVHR procedure time, particularly during mesh preparation/positioning. These operative time savings may translate into reduced operating room costs and improved surgeon/operating room efficiency

The Active Corona of HD 35850 (F8 V)

We present Extreme Ultraviolet Explorer spectroscopy and photometry of the nearby F8 V star HD 35850 (HR 1817). The EUVE spectra reveal 28 emission lines from Fe IX and Fe XV to Fe XXIV. The Fe XXI 102, 129 A ratio yields an upper limit for the coronal electron density, log n < 11.6 per cc. The EUVE SW spectrum shows a small but clearly detectable continuum. The line-to-continuum ratio indicates approximately solar Fe abundances, 0.8 < Z < 1.6. The resulting emission-measure distribution is characterized by two temperature components at log T of 6.8 and 7.4. The EUVE spectra have been compared with non-simultaneous ASCA SIS spectra of HD 35850. The SIS spectrum shows the same temperature distribution as the EUVE DEM analysis. However, the SIS spectral firs suggest sub-solar abundances, 0.34 < Z < 0.81. Although some of the discrepancy may be the result of incomplete X-ray line lists, we cannot explain the disagreement between the EUVE line-to-continuum ratio and the ASCA-derived Fe abundance. Given its youth (t ~ 100 Myr), its rapid rotation (v sin i ~ 50 km/s), and its high X-ray activity (Lx ~ 1.5E+30 ergs/s), HD 35850 may represent an activity extremum for single, main-sequence F-type stars. The variability and EM distribution can be reconstructed using the continuous flaring model of Guedel provided that the flare distribution has a power-law index of 1.8. Similar results obtained for other young solar analogs suggest that continuous flaring is a viable coronal heating mechanism on rapidly rotating, late-type, main-sequence stars.Comment: 32 pages incl. 14 figures and 3 tables. To appear in the 1999 April 10 issue of The Astrophysical Journa

Evaluation of E CHO

Purpose. Operative efficiency improvements for laparoscopic ventral hernia repair (LVHR) have focused on reducing operative time while maintaining overall repair efficacy. Our objective was to evaluate procedure time and positioning accuracy of an inflatable mesh positioning device (Echo PS Positioning System), as compared to a standard transfascial suture technique, using a porcine model of simulated LVHR. Methods. The study population consisted of seventeen general surgeons (n = 17) that performed simulated LVHR on seventeen (n = 17) female Yorkshire pigs using two implantation techniques: (1) Ventralight ST Mesh + Echo PS Positioning System (Echo PS) and (2) Ventralight ST Mesh + transfascial sutures (TSs). Procedure time and mesh centering accuracy overtop of a simulated surgical defect were evaluated. Results. Echo PS demonstrated a 38.9% reduction in the overall procedure time, as compared to TS. During mesh preparation and positioning, Echo PS demonstrated a 60.5% reduction in procedure time (P < 0.0001). Although a trend toward improved centering accuracy was observed for Echo PS (16.2%), this was not significantly different than TS. Conclusions. Echo PS demonstrated a significant reduction in overall simulated LVHR procedure time, particularly during mesh preparation/positioning. These operative time savings may translate into reduced operating room costs and improved surgeon/operating room efficiency

Chandra Observations of the Pleiades Open Cluster: X-ray Emission from Late-B to Early-F Type Binaries

We present the analysis of a 38.4 ks and a 23.6 ks observation of the core of the Pleiades open cluster. The Advanced CCD Imaging Spectrometer on board the Chandra X-ray Observatory detected 99 X-ray sources in a 17'X17' region, including 18 of 23 Pleiades members. Five candidate Pleiades members have also been detected, confirming their cluster membership. Fifty-seven sources have no optical or near-infrared counterparts to limiting magnitudes V=22.5 and J=14.5. The unidentified X-ray sources are probably background AGN and not stars. The Chandra field of view contains seven intermediate mass cluster members. Five of these, HII 980 (B6 + G), HII 956 (A7 + F6), HII 1284 (A9 + K), HII 1338 (F3 + F6), and HII 1122 (F4 + K), are detected in this study. All but HII 1284 have high X-ray luminosity and soft X-ray spectra. HII 1284 has X-ray properties comparable to non-flaring K-type stars. Since all five stars are visual or spectroscopic binaries with X-ray properties similar to F-G stars, the late-type binary companions are probably producing the observed coronal X-ray emission. Strengthening this conclusion is the nondetection by Chandra of two A stars, HII 1362 (A7, no known companion) and HII 1375 (A0 + A SB) with X-ray luminosity upper limits 27-54 times smaller than HII 980 and HII 956, the B6-A7 stars with cooler companions. Despite the low number statistics, the Chandra data appear to confirm the expectation that late-B and A stars are not strong intrinsic X-ray sources. The ACIS spectra and hardness ratios suggest a gradual increase in coronal temperature with decreasing mass from F4 to K. M stars appear to have somewhat cooler coronae than active K stars.Comment: 22 pages, 4 figures, 7 tables, to appear in Ap

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

<p>Abstract</p> <p>Background</p> <p>Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for developing therapeutics for treating diseases of aging. The NAD⁺-dependent protein deacetylase SIRT1 has been implicated as one of the key downstream regulators of CR in yeast, rodents, and humans. Small molecule activators of SIRT1 have been identified that exhibit efficacy in animal models of diseases typically associated with aging including type 2 diabetes. To identify molecular processes induced in the liver of mice treated with two structurally distinct SIRT1 activators, SIRT501 (formulated resveratrol) and SRT1720, for three days, we utilized a systems biology approach and applied Causal Network Modeling (CNM) on gene expression data to elucidate downstream effects of SIRT1 activation.</p> <p>Results</p> <p>Here we demonstrate that SIRT1 activators recapitulate many of the molecular events downstream of CR <it>in vivo</it>, such as enhancing mitochondrial biogenesis, improving metabolic signaling pathways, and blunting pro-inflammatory pathways in mice fed a high fat, high calorie diet.</p> <p>Conclusion</p> <p>CNM of gene expression data from mice treated with SRT501 or SRT1720 in combination with supporting <it>in vitro </it>and <it>in vivo </it>data demonstrates that SRT501 and SRT1720 produce a signaling profile that mirrors CR, improves glucose and insulin homeostasis, and acts via SIRT1 activation <it>in vivo</it>. Taken together these results are encouraging regarding the use of small molecule activators of SIRT1 for therapeutic intervention into type 2 diabetes, a strategy which is currently being investigated in multiple clinical trials.</p

Training attention control of very preterm infants: protocol for a feasibility study of the Attention Control Training (ACT)

Background Children born preterm may display cognitive, learning, and behaviour difficulties as they grow up. In particular, very premature birth (gestation age between 28 and less than 32 weeks) may put infants at increased risk of intellectual deficits and attention deficit disorder. Evidence suggests that the basis of these problems may lie in difficulties in the development of executive functions. One of the earliest executive functions to emerge around 1 year of age is the ability to control attention. An eye-tracking-based cognitive training programme to support this emerging ability, the Attention Control Training (ACT), has been developed and tested with typically developing infants. The aim of this study is to investigate the feasibility of using the ACT with healthy very preterm (VP) infants when they are 12 months of age (corrected age). The ACT has the potential to address the need for supporting emerging cognitive abilities of VP infants with an early intervention, which may capitalise on infants’ neural plasticity. Methods/design The feasibility study is designed to investigate whether it is possible to recruit and retain VP infants and their families in a randomised trial that compares attention and social attention of trained infants against those that are exposed to a control procedure. Feasibility issues include the referral/recruitment pathway, attendance, and engagement with testing and training sessions, completion of tasks, retention in the study, acceptability of outcome measures, quality of data collected (particularly, eye-tracking data). The results of the study will inform the development of a larger randomised trial. Discussion Several lines of evidence emphasise the need to support emerging cognitive and learning abilities of preterm infants using early interventions. However, early interventions with preterm infants, and particularly very preterm ones, face difficulties in recruiting and retaining participants. These problems are also augmented by the health vulnerability of this population. This feasibility study will provide the basis for informing the implementation of an early cognitive intervention for very preterm infants. Trial registration Registered Registration ID: NCT03896490. Retrospectively registered at Clinical Trials Protocol Registration and Results System (clinicaltrials.gov)