Status Processes and Mental Ability Test Scores

The expected consequences of a score on an ability test can constrain individual performance. The authors predict that status processes, including status differences and the differences in rewards and costs that result, will produce differences in ability test scores between high-status and low-status individuals. In three controlled experi- ments, participants randomly assigned low status scored lower on a standard test of mental ability (the Raven Progressive Matrices) than did participants assigned high status. For both men and women, the difference in ability test score between low-status and high-status participants was about half a standard deviation. The results suggest the need to account for status differences in any at- tempt to measure mental ability accuratel

How to establish the outer limits of reperfusion therapy

Reperfusion therapy with intravenous alteplase and endovascular therapy are effective treatments for selected patients with acute ischemic stroke. Guidelines for treatment are based upon randomized trials demonstrating substantial treatment effects for highly selected patients based on time from stroke onset and imaging features. However, patients beyond the current established guidelines might benefit with lesser but still clinically significant treatment effects. The STAIR (Stroke Treatment Academic Industry Roundtable) XI meeting convened a workgroup to consider the “outer limits” of reperfusion therapy by defining the current boundaries, and exploring optimal parameters and methodology for determining the outer limits. In addition to statistical significance, the minimum clinically important difference should be considered in exploring the limits of reperfusion therapy. Societal factors and quality of life considerations should be incorporated into assessment of treatment efficacy. The threshold for perception of benefit in the medical community may differ from that necessary for the Food and Drug Administration approval. Data from alternative sources such as platform trials, registries and large pragmatic trials should supplement randomized controlled trials to improve generalizability to routine clinical practice. Further interactions between industry and academic centers should be encouraged

Acute stroke imaging research roadmap IV : imaging selection and outcomes in acute stroke clinical trials and practice

Background and Purpose: The Stroke Treatment Academic Industry Roundtable (STAIR) sponsored an imaging session and workshop during the Stroke Treatment Academic Industry Roundtable XI via webinar on October 1 to 2, 2020, to develop consensus recommendations, particularly regarding optimal imaging at primary stroke centers. Methods: This forum brought together stroke neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss imaging priorities in the light of developments in reperfusion therapies, particularly in an extended time window, and reinvigorated interest in brain cytoprotection trials. Results: The imaging session summarized and compared the imaging components of recent acute stroke trials and debated the optimal imaging strategy at primary stroke centers. The imaging workshop developed consensus recommendations for optimizing the acquisition, analysis, and interpretation of computed tomography and magnetic resonance acute stroke imaging, and also recommendations on imaging strategies for primary stroke centers. Conclusions: Recent positive acute stroke clinical trials have extended the treatment window for reperfusion therapies using imaging selection. Achieving rapid and high-quality stroke imaging is therefore critical at both primary and comprehensive stroke centers. Recommendations for enhancing stroke imaging research are provided

The effect of substrate resource level on the colonization and emigration rates of several taxa of drifting invertebrates.

The purpose of this study was to investigate the effect of substrate resource level on emigration rates of the drift community as a whole by evaluating the response of several taxa to an increase in food (algae) abundance. The effects of food abundance were tested using channels placed in a natural stream through which invertebrates could drift freely. Half of the channels contained stones with normal algal levels and half contained stones with augmented algae levels in order to test the response of drifting invertebrates to differences in substrate resource levels.http://deepblue.lib.umich.edu/bitstream/2027.42/54534/1/2973.pdfDescription of 2973.pdf : Access restricted to on-site users at the U-M Biological Station

Long Term Resource Monitoring Program Water Quality Component Review

partners with scientific and technical support. All reports in this series receive anonymous peer review. Cover graphic by Mi Ae Lipe-Butterbrodt Mention of trade names or commercial products does not constitute endorsemen

Developing a shared understanding of the Upper Mississippi River: the foundation of an ecological resilience assessment

The Upper Mississippi River System (UMRS) is a large and complex floodplain river ecosystem that spans the jurisdictions of multiple state and federal agencies. In support of ongoing ecosystem restoration and management by this broad partnership, we are undertaking a resilience assessment of the UMRS. We describe the UMRS in the context of an ecological resilience assessment. Our description articulates the temporal and spatial extent of our assessment of the UMRS, the relevant historical context, the valued services provided by the system, and the fundamental controlling variables that determine its structure and function. An important objective of developing the system description was to determine the simplest, adequate conceptual understanding of the UMRS. We conceptualize a simplified UMRS as three interconnected subsystems: lotic channels, lentic off-channel areas, and floodplains. By identifying controlling variables within each subsystem, we have developed a shared understanding of the basic structure and function of the UMRS, which will serve as the basis for ongoing quantitative evaluations of factors that likely contribute to the resilience of the UMRS. As we undertake the subsequent elements of a resilience assessment, we anticipate our improved understanding of interactions, feedbacks, and critical thresholds will assist natural resource managers to better recognize the system's ability to adapt to existing and new stresses