15,365 research outputs found
An empirical investigation into the use of product development in the educational furniture industry : a thesis presented in fulfilment of the requirements for the Master of Technology in Product Development at Massey University, Palmerston North, New Zealand
An empirical investigation into the use of product development in the educational furniture industry is summarised in this thesis. New Zealand furniture manufacturers are facing increased competition from imported furniture and are also exporting more and more furniture. Developing new products is therefore important to the New Zealand furniture industry's growth. This research was based on a small furniture-manufacturing firm from Hastings, New Zealand called Furnware Industries Limited (Furnware). A product development process was developed to their specific needs by comparing their current product development activities with identified best practices in product development. Those parts of the current activities that worked well were amalgamated with the structured Stage-Gateœ process of Cooper (1998). This process was tested by using it to develop a Mobile Technology Education Workstation range for Furnware. The aim of the project was to develop a new product for Furnware to sell and to simultaneously test the developed process. Once the project was completed, an evaluation of the product development process used was undertaken. Several areas for improvement were identified and a revised process outlined. The use of Computer-Aided Design (CAD) software was identified as another area of improvement that would assist both product development activities and existing manufacturing processes at Furnware. Consequently, a CAD package best suited to Furnware is selected using a structured process. The three main outcomes of the research were: 1. A product development process suited to Furnware. 2. A Mobile Technology Education Workstation range of products ready for launch, pending minor adjustments and testing. 3. A CAD software package suggested for use at Furnware
CD4:CD8 ratio and CD8+ cell count for prognosticating mortality in HIV-infected patients on antiretroviral therapy.
Treatment of Aspergillosis.
Infections caused by Aspergillus spp. remain associated with high morbidity and mortality. While mold-active antifungal prophylaxis has led to a decrease of occurrence of invasive aspergillosis (IA) in those patients most at risk for infection, breakthrough IA does occur and remains difficult to diagnose due to low sensitivities of mycological tests for IA. IA is also increasingly observed in other non-neutropenic patient groups, where clinical presentation is atypical and diagnosis remains challenging. Early and targeted systemic antifungal treatment remains the most important predictive factor for a successful outcome in immunocompromised individuals. Recent guidelines recommend voriconazole and/or isavuconazole for the primary treatment of IA, with liposomal amphotericin B being the first alternative, and posaconazole, as well as echinocandins, primarily recommended for salvage treatment. Few studies have evaluated treatment options for chronic pulmonary aspergillosis (CPA), where long-term oral itraconazole or voriconazole remain the treatment of choice
The Distributional Effects of an Investment-Based Social Security System
In this paper we study the distributional impact of a change from the existing pay-as-you-go Social Security system to one that combines both pay-as-you-go and investment-based elements. Critics of investment-based plans have been concerned that such plans might reduce the retirement income of low-paid workers or of surviving spouses relative to what they would get from Social Security, and might therefore increase the extent of poverty among the aged. Our analysis in this paper shows that this is generally not the case, even in plans that make no special effort to maintain or increase redistribution. Our principal finding is that virtually all of the demographic groups that we examine would receive higher average benefits under a mixed system with an investment-based component than the benefits that they would receive under current Social Security rules. There would also be a smaller share of individuals with benefits below the poverty line even though the total cost of funding the mixed system -- a three percent saving contribution rather than a six percent rise in the tax rate -- is substantially lower than that of funding the pay-as-you-go system. Our individual-level data permit us to go beyond comparing group means to analyze the full distribution of the benefits that individuals would receive under the two different systems. These comparisons show that the overwhelming majority of individuals would have higher benefits with the investment-based system than with the pure pay-as-you-go system. The relatively small number of individuals who would receive less from the investment-based system is further reduced when the effects of the Supplementary Security Income program is taken into account. These basic conclusions remain true even if the future rate of return in the investment-based component of the mixed system is substantially less than past experience implies.
Global deposition of total reactive nitrogen oxides from 1996 to 2014 constrained with satellite observations of NO2 columns
Reactive nitrogen oxides (NOy) are a major constituent of the nitrogen deposited from the atmosphere, but observational constraints on their deposition are limited by poor or nonexistent measurement coverage in many parts of the world. Here we apply NO2 observations from multiple satellite instruments (GOME, SCIAMACHY, and GOME-2) to constrain the global deposition of NOy over the last 2 decades. We accomplish this by producing top-down estimates of NOx emissions from inverse modeling of satellite NO2 columns over 1996–2014, and including these emissions in the GEOS-Chem chemical transport model to simulate chemistry, transport, and deposition of NOy. Our estimates of long-term mean wet nitrate (NO3−) deposition are highly consistent with available measurements in North America, Europe, and East Asia combined (r = 0.83, normalized mean bias = −7%, N = 136). Likewise, our calculated trends in wet NO3− deposition are largely consistent with the measurements, with 129 of the 136 gridded model–data pairs sharing overlapping 95% confidence intervals. We find that global mean NOy deposition over 1996–2014 is 56.0TgNyr−1, with a minimum in 2006 of 50.5TgN and a maximum in 2012 of 60.8TgN. Regional trends are large, with opposing signs in different parts of the world. Over 1996 to 2014, NOy deposition decreased by up to 60% in eastern North America, doubled in regions of East Asia, and declined by 20% in parts of western Europe. About 40% of the global NOy deposition occurs over oceans, with deposition to the North Atlantic Ocean declining and deposition to the northwestern Pacific Ocean increasing. Using the residual between NOx emissions and NOy deposition over specific land regions, we investigate how NOx export via atmospheric transport has changed over the last 2 decades. Net export from the continental United States decreased substantially, from 2.9TgNyr−1 in 1996 to 1.5TgNyr−1 in 2014. Export from China more than tripled between 1996 and 2011 (from 1.0 to 3.5TgNyr−1), before a striking decline to 2.5TgNyr−1 by 2014. We find that declines in NOx export from some western European countries have counteracted increases in emissions from neighboring countries to the east. A sensitivity study indicates that simulated NOy deposition is robust to uncertainties in NH3 emissions with a few exceptions. Our novel long-term study provides timely context on the rapid redistribution of atmospheric nitrogen transport and subsequent deposition to ecosystems around the world.This work was supported by NSERC and Environment and Climate Change Canada. We acknowledge the free use of tropospheric NO2 column data from the GOME, SCIAMACHY, and GOME-2 sensors from www.temis.nl. We further acknowledge the NADP, CAPMoN, EMEP, and EANET regional monitoring networks as well as the World Data Centre for Precipitation Chemistry for access to wet deposition data. (NSERC; Environment and Climate Change Canada)https://www.atmos-chem-phys.net/17/10071/2017/acp-17-10071-2017.pdfhttps://www.atmos-chem-phys.net/17/10071/2017/acp-17-10071-2017.pdfhttps://www.atmos-chem-phys.net/17/10071/2017/acp-17-10071-2017.pdfPublished versionPublished versio
Global deposition of total reactive nitrogen oxides from 1996 to 2014 constrained with satellite observations of NO2 columns
Reactive nitrogen oxides (NOy) are a major constituent of the nitrogen deposited from the atmosphere, but observational constraints on their deposition are limited by poor or nonexistent measurement coverage in many parts of the world. Here we apply NO2 observations from multiple satellite instruments (GOME, SCIAMACHY, and GOME-2) to constrain the global deposition of NOy over the last two decades. We accomplish this by producing top-down estimates of NOx emissions from inverse modeling of satellite NO2 columns over 1996–2014, and including these emissions in the GEOS-Chem chemical transport model to simulate chemistry, transport, and deposition of NOy. Our estimates of long-term mean wet nitrate (NO3−) deposition are highly consistent with available measurements in North America, Europe, and East Asia combined (r = 0.83, normalized mean bias = −7 %, N = 136). Likewise, our calculated trends in wet NO3− deposition are largely consistent with the measurements, with 129 of the 136 gridded model-data pairs sharing overlapping 95 % confidence intervals. We find that global mean NOy deposition over 1996–2014 is 56.0 Tg N yr−1, with a minimum in 2006 of 50.5 Tg N and a maximum in 2012 of 60.8 Tg N. Regional trends are large, with opposing signs in different parts of the world. Over 1996 to 2014, NOy deposition decreased by up to 60 % in eastern North America, doubled in regions of East Asia, and declined by 20 % in parts of Western Europe. About 40 % of the global NOy deposition occurs over oceans, with deposition to the North Atlantic Ocean declining and deposition to the northwestern Pacific Ocean increasing. Using the residual between NOx emissions and NOy deposition over specific land regions, we investigate how NOx export via atmospheric transport has changed over the last two decades. Net export from the continental United States decreased substantially, from 2.9 Tg N yr−1 in 1996 to 1.5 Tg N yr−1 in 2014. On the other hand, export from China more than tripled between 1996 and 2011 (from 1.0 Tg N yr−1 to 3.5 Tg N yr−1), before a striking decline to 2.5 Tg N yr−1 by 2014. We find that declines in NOx export from some Western European countries have counteracted increases in emissions from neighbouring countries to the east. A sensitivity study indicates that simulated NOy deposition is robust to uncertainties in NH3 emissions with a few exceptions. Our novel long-term study provides timely context on the rapid redistribution of atmospheric nitrogen transport and subsequent deposition to ecosystems around the world.https://www.atmos-chem-phys-discuss.net/acp-2016-1100/acp-2016-1100.pdfhttps://www.atmos-chem-phys-discuss.net/acp-2016-1100/acp-2016-1100.pdfhttps://www.atmos-chem-phys-discuss.net/acp-2016-1100/acp-2016-1100.pdfPublished versionPublished versio
The Weil-Petersson gradient flow of renormalized volume and 3-dimensional convex cores
In this paper, we use the Weil-Petersson gradient flow for renormalized
volume to study the space of convex cocompact hyperbolic structures
on the relatively acylindrical 3-manifold . Among the cases of interest
are the deformation space of an acylindrical manifold and the Bers slice of
quasi-Fuchsian space associated to a fixed surface. To treat the possibility of
degeneration along flow-lines to peripherally cusped structures, we introduce a
surgery procedure to yield a surgered gradient flow that limits to the unique
structure with totally geodesic convex core
boundary facing . Analyzing the geometry of structures along a flow line, we
show that if is the renormalized volume of , then
is bounded below by a linear function of the
Weil-Petersson distance ,
with constants depending only on the topology of . The surgered flow gives a
unified approach to a number of problems in the study of hyperbolic
3-manifolds, providing new proofs and generalizations of well-known theorems
such as Storm's result that has minimal volume for
acylindrical and the second author's result comparing convex core volume and
Weil-Petersson distance for quasifuchsian manifolds
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