Pathologist Concordance for Ovarian Carcinoma Subtype Classification and Identification of Relevant Histologic Features Using Microscope and Whole Slide Imaging.

CONTEXT.—: Despite several studies focusing on the validation of whole slide imaging (WSI) across organ systems or subspecialties, the use of WSI for specific primary diagnosis tasks has been underexamined. OBJECTIVE.—: To assess pathologist performance for the histologic subtyping of individual sections of ovarian carcinomas using a light microscope and WSI. DESIGN.—: A panel of 3 experienced gynecologic pathologists provided reference subtype diagnoses for 212 histologic sections from 109 ovarian carcinomas based on optical microscopy review. Two additional attending pathologists provided diagnoses and also identified the presence of a set of 8 histologic features important for ovarian tumor subtyping. Two experienced gynecologic pathologists and 2 fellows reviewed the corresponding WSI images for subtype classification and feature identification. RESULTS.—: Across pathologists specialized in gynecologic pathology, concordance with the reference diagnosis for the 5 major ovarian carcinoma subtypes was significantly higher for a pathologist reading on a microscope than each of 2 pathologists reading on WSI. Differences were primarily due to more frequent classification of mucinous carcinomas as endometrioid with WSI. Pathologists had generally low agreement in identifying histologic features important to ovarian tumor subtype classification with either an optical microscopy or WSI. This result suggests the need for refined histologic criteria for identifying such features. Interobserver agreement was particularly low for identifying intracytoplasmic mucin with WSI. Inconsistencies in evaluating nuclear atypia and mitoses with WSI were also observed. CONCLUSIONS.—: Further research is needed to specify the reasons for these diagnostic challenges and to inform users and manufacturers of WSI technology

The Revised 28-Item Racial and Ethnic Microaggressions Scale (R28REMS): Examining the Factorial Structure for Black, Latino/Hispanic, and Asian Young Adults

Racial and ethnic discrimination has adverse effects on the health and mental health outcomes of people of color. Evidence indicates that modern discriminatory behavior is often a product of brief, commonplace, and often subtle acts that convey derogatory messages to people of color, known as racial and ethnic microaggressions. Accurately measuring microaggression is essential to understanding and preventing behaviors that are consistent with this complex construct. The current study examines evidence for the reliability and validity of the Racial and Ethnic Microaggressions Scale(REMS). Data from a sample of 286 randomly selected Black, Latino/Hispanic, and Asian young adults (ages 18–35 years old) were used to examine the REMS. Exploratory factor analysis was used to assess the factor structure of the REMS across racial and ethnic groups. Findings support the reliability of the instrument but also suggest that a shorter 5-factor model offers a promising alternative to the original 6-factor instrument. Results also reveal differences between how members of different racial and ethnic groups conceptualize microaggression. Recommendations for using a revised version of the instrument (the Revised 28-Item REMS) and for future research aimed at optimally measuring microaggression are identified

Youth-led Participatory Action Research: Promoting Youth Voice and Adult Support in Afterschool Programs.

Afterschool programs often find it challenging to retain participants as they transition from child hood into early adolescence and enter middle school (Deschenes et al., 2010). During this developmental period, many young people, as they experience a growing need for autonomy, begin to disconnect from pro-social institutions (Eccles et al, 1993; Meece, Anderman, & Anderman, 2006)