Non-Human Primate MRI Cardiac Functional Data

This file consists of MRI datasets from eight naive non-human primates. The datasets are repeated twice for test and retest acquisitions. Each dataset includes cardiac structural, tagging, and phase contrast MRI images

Body weights, heart rates, LV structural characteristics, ejection fraction, cardiac output and LV mass from imaged NHPs.

<p>Body weights, heart rates, LV structural characteristics, ejection fraction, cardiac output and LV mass from imaged NHPs.</p

Temporal graphs depicting stability of physiological parameters during the course of the imaging study.

<p>Physiological data (heart rate, respiratory rate, oxygen saturation (SP0₂), and CO₂ levels) from the eight NHPs recorded during the MR imaging experiments. Solid line depicts the mean data, while the error bars denote the ± one standard deviation. Measurement sampling was obtained every minute during the study.</p

Results from inter-subject variability analyses for diastolic biomarkers.

<p>Results from inter-subject variability analyses for diastolic biomarkers.</p

Temporal average rotation curves.

<p>The curves are depicted for representative short axis slices located at the LV base, mid and apex for the imaged NHP cohort (n = 8). The curves represent the mean value, while the error bars represent one standard deviation measurement. The sampling rate for the error bars is set arbitrarily.</p

Spatial heterogeneity of quantified diastolic biomarkers.

<p>Comparisons of quantified diastolic biomarkers averaged over three slices: apical, mid-ventricular and basal. Asterisk denotes a significant difference in values at the p<0.05 significance level using a 2-tailed paired t-test. Regional differences are observed for average CSR, and peak untwist rate.</p

Results from inter-subject variability analyses for systolic biomarkers.

<p>Results from inter-subject variability analyses for systolic biomarkers.</p

Plots depicting Bland-Altman repeatability analysis for all quantified biomarkers.

<p>Bland-Altman plots of quantified (a) systolic biomarkers, and (b) diastolic biomarkers. The solid gray line represents the linear regression trend line that associates the difference between the two measurements with the average between the two measurements. The solid black lines represent the standard deviations of the difference between the two measurements. Sys = systolic, Dia = diastolic, CS = circumferential strain, LS = longitudinal strain, CSR = circumferential strain-rate, LSR = longitudinal strain-rate.</p

Results from intra-subject repeatability analyses for diastolic biomarkers.

<p>Results from intra-subject repeatability analyses for diastolic biomarkers.</p

Temporal inter-relationships between LV mechanics and LV chamber hemodynamics.

<p>(a) Comparisons of temporal responses of circumferential strain, torsion and composite velocity (temporally scaled to a standard heart rate). Solid line depicts the mean value, and error bars depict the ± one standard deviation values. The red vertical solid line corresponds to the time of peak circumferential strain (end-systole). A partial loop depicts (b) mean torsion versus mean circumferential strain, (c) mean circumferential strain versus mean velocity, and (d) mean torsion versus mean velocity. The red dots in (b-d) correspond to the red line in (a). Key timing events corresponding to peak aortic outflow, peak mitral inflow, peak circumferential strain and peak torsion are also indicated in the loops (c-d).</p