23 research outputs found
Characteristics of Cases and Controls in the Multiethnic Cohort Study (MEC) and the Women's Health Initiative Study (WHI).
1<p>Age at diagnosis for cases and age at blood draw for controls in the MEC; age at baseline for cases and controls in the WHI.</p>2<p>Japanese in the MEC, approximately 25% Chinese, 50% Japanese, and 25% other groups in the WHI.</p
Association between <i>HNF1B</i> variants and endometrial cancer.
1<p>Odds ratio per allele obtained from logistic regression adjusting for age (continuous), 4 ancestry principal components, BMI (<25, 25-<30, ≥30 kg/m<sup>2</sup>).</p>2<p>P interaction with race/ethnicity in the MEC ≥0.63; P interaction with race/ethnicity in the WHI ≥0.21;</p>3<p>Combined ORs were calculated using a fixed effects model.</p
Association between <i>HNF1B</i> variants and Type I and Type II endometrial cancer.
1<p>Odds ratio per allele obtained using polytomous logistic regression adjusting for age (continuous), 4 ancestry principal components, and BMI (<25, 25-<30, ≥30 kg/m<sup>2</sup>).</p>2<p>Combined ORs were calculated using a fixed effects model.</p
Association between <i>HNF1B</i> variants and endometrial cancer by diabetes status.
1<p>Odds ratio per allele obtained from logistic regression adjusting for age (continuous), 4 ancestry principal components and BMI.</p>2<p>Combined ORs were calculated using a fixed effects model.</p><p>Test for interaction was assessed using log-likelihood test statistics comparing models with and without the interaction term.</p><p>P interaction for rs4430796 was 0.028 (WHI) and 0.93 (MEC); P interaction for rs7501939 was 0.054 (WHI) and 0.58 (MEC).</p
Results of gene-based analysis in discovery data and replication cohorts.
<p>Results of gene-based analysis in discovery data and replication cohorts.</p
The CFS family carrying the protective rare variant rs149974858.
<p>A) The variant rs149974858 segregates with BP in a 17-member CFS family. Squares represent males and circles represent females. Half-filled subjects represent the carriers of the rare variant rs149974858. Grey subjects represent no information. Age of each subject is presented in parenthesis. B) The distribution of corresponding residuals of SBP, DBP, PP and BMI are presented.</p
Linkage region on chromosome 16 of white participants in CFS.
<p>Linkage peak on chromosome 16 for SBP. The linkage curves are plotted with (red curve) and without (blue curve) adjusting for the risk score defined by the 13 coding variants as a covariate. The positions of the 13 coding variants are listed under the linkage peak and above the genes.</p
Tissue-specific gene expression of <i>RBFOX1</i> from GTEx database (http://www.gtexportal.org/home/gene/RBFOX1).
<p>Tissue-specific gene expression of <i>RBFOX1</i> from GTEx database (<a href="http://www.gtexportal.org/home/gene/RBFOX1" target="_blank">http://www.gtexportal.org/home/gene/RBFOX1</a>).</p
Characteristics of white participants in the Cleveland Family Study.
<p>Characteristics of white participants in the Cleveland Family Study.</p