12 research outputs found

    Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase

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    A series of C3 O-functionalized 2-acetamido-2-deoxy-?4-߭D-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the in?uenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits in?uenza virus sialidase at a sub-占level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated.Office of the Snr Dep Vice Chancellor, Institute for GlycomicsNo Full Tex

    Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase

    No full text
    A series of C3 <i>O</i>-functionalized 2-acetamido-2-deoxy-Δ<sup>4</sup>-β-d-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the influenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits influenza virus sialidase at a sub-μM level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated
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