12 research outputs found
Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase
No full textA series of C3 O-functionalized 2-acetamido-2-deoxy-?4-߭D-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the in?uenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits in?uenza virus sialidase at a sub-占level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated.Office of the Snr Dep Vice Chancellor, Institute for GlycomicsNo Full Tex
A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs
No full textExploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase
No full textA series of C3 <i>O</i>-functionalized 2-acetamido-2-deoxy-Δ<sup>4</sup>-β-d-glucuronides were synthesized to explore
noncharge interactions in subsite 2 of the influenza virus sialidase
active site. In complex with A/N8 sialidase, the parent compound (C3
OH) inverts its solution conformation to bind with all substituents
well positioned in the active site. The parent compound inhibits influenza
virus sialidase at a sub-μM level; the introduction of small
alkyl substituents or an acetyl group at C3 is also tolerated
Unsaturated N-acetyl- D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase
No full textStructural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus
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Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: new insights for drug discovery
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Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry
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