1 research outputs found
Nickel-Catalyzed Suzuki Cross Couplings with Unprotected Allylic Alcohols Enabled by Bidentate <i>N</i>‑Heterocyclic Carbene (NHC)/Phosphine Ligands
Cross couplings between simple allylic
alcohols and aryl and vinyl
boronic acids are efficiently catalyzed by nickel(0) catalysts and
bidentate <i>N</i>-heterocyclic carbene/phosphine ligands.
The bidentate nature of the ligand is shown to extend catalyst lifetime
and enable high yields of the corresponding cross-coupling products.
X-ray crystallography confirms the bidentate nature of the ligand
scaffold. Multistep cross coupling-alkene/alkyne insertions reactions
are also conducted and the bidentate nature of the substrate makes
the pendant phosphine of the ligand unnecessary