Validation of the <i>KCNK3</i> rs2586886 associations with BP in independent multi-ethnic populations.

<p>Validation of the <i>KCNK3</i> rs2586886 associations with BP in independent multi-ethnic populations.</p

Descriptive characteristics^a of the PAGE and FBBP studies by race/ethnicity.

<p>Descriptive characteristics<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164132#t001fn002" target="_blank">^a</a> of the PAGE and FBBP studies by race/ethnicity.</p

Distribution of study characteristics by study and overall.

<p>Distribution of study characteristics by study and overall.</p

Association results (p-values) and correlation structure for all SNPs in the 16q12.2/<i>FTO</i> region and lnBMI among African Americans using rs56137030 to calculate correlation among SNPs (LocusZoom plots).

<p>The top half of each figure has physical position along the x axis, and the −log₁₀ of the meta-analysis p-value on the y-axis. Each dot on the plot represents the p-value of the association for one SNP with lnBMI across all studies. The most significant SNP (rs56137030) is marked as a purple diamond. The color scheme represents the pairwise correlation (r²) for the SNPs across the 16q12.2/<i>FTO</i> region with the most significant SNP (rs56137030). Gray squares indicate that correlation was missing for this p-value because the variant was monomorphic in EA. The bottom half of the figure shows the position of the genes across the region. A and B show the same region and results. The only difference between A and B is that in A correlation with the most significant SNP (rs56137030) was calculated based on EAs, specifically based on data from 65 European Americans (Utah residents with Northern and Western European ancestry from the CEPH collection, CEU) sequenced as part of the 1000 Genomes Project and B correlation was based on 61 African Americans from the South-west (ASW) and sequenced as part of the 1000 Genomes Project.</p

Association between SNPs in the <i>FTO</i> region and BMI for all studies combined.

<p><b>a</b>SNPposition based on build 37.</p><p><b>b</b>Coding = coding allele, Base = baseline allele (risk estimates provide the log additive effect per copy of the coding allele).</p><p><b>c</b>CAF = coding allele frequency.</p><p><b>d</b>Rsq = measurement of imputation accuracy, ranging from 0 (low) to 1 (high).</p