Pustular psoriasis and the potential therapeutic usage of an IL-36 receptor monoclonal antibody

Pustular psoriasis is an uncommon subtype of psoriasis that dramatically affects the quality of life of affected patients. Pustules can emerge anywhere along the trunk, limbs, soles, palms, and fingers, which debilitates the functionality of these appendages. Currently, there are no approved treatments for pustular psoriasis in the US; off-label usage of psoriasis vulgaris medications is usually prescribed. These treatments are insufficient for patients with difficult to manage or severe forms of pustular psoriasis. Psoriasis vulgaris biologic medications mainly target the IL-17 and IL-23 axis. However, novel clinical findings have demonstrated that pustular psoriasis’s central inflammatory axis depends on the dysregulation of the IL-36 family of cytokines. The lack of inhibition of IL-36α, IL-36β, IL-36γ, as well as the absence of insufficiency of an IL-36 receptor antagonist (IL-36RA), is involved in the upregulation of proinflammatory cytokines and neutrophil chemotaxis necessary for pustular lesion formation. An IL-36 receptor monoclonal antibody can potentially disrupt the IL-36 inflammatory loop and inhibit the pathogenesis of pustular psoriasis. Spesolimab is an IL-36 receptor (IL-36R) monoclonal antibody undergoing clinical trials for the treatment of pustular psoriasis that has exhibited promising results

Les travées droites intermédiaires entre la nef et le chœur : dénominations, fonctions, marques dans l’espace ? Étude de cas dans le diocèse de Langres

Dans les églises sans transept à nef unique, l’existence d’une travée supplémentaire située entre la travée droite du chœur et la nef, en général placée à la verticale du clocher, interroge sur la fonction de cette travée et sa dénomination. Cette question s’est imposée lors de mes recherches au cours de ma thèse sur les petites églises rurales des xiie et xiiie siècles dans le diocèse de Langres que la répétition de cet espace semblait caractériser. Le but, ici, est d’évoquer ces travées qui..

Learning to Co-Create the Solutions We Seek: The Art of Hosting a Nonprofit Organization

The Art of Hosting is an emergent leadership model that compliments rapidly changing business needs and environments. This paper presents grounded theory on Art of Hosting components, including the Four Fold Invitation, Hobbit Tools, Five Diamonds of Participation, and Harvesting. An in-depth case study describes the use of Hosting architecture as the design for a nonprofit organization. While the Art of Hosting is effective for involving the community in discussions to co-create solutions to difficult problems, the practice does not easily facilitate a transition from discussion to action. As a framework for operating a nonprofit organization, further research is necessary to identify ways in which the Hosting practice may strengthen such a transition. As a personal leadership practice, the Art of Hosting may contribute to the organization\u27s ability to connect within itself and its community

Typhlocharis vicariantes del Estrecho de Gibraltar. I: Typhlocharis armata Coiffait, 1969 (Coleoptera, Caraboidea, Trechidae)

This first part about the vicariant Typhlocharis from Gibraltar Strait is dedicated to Typhlocharis armata Coiffait, 1969; a second paper will cover T. silvanoides Dieck, 1869. The studied material was obtained in four field campaigns carried out in the south of Spain and north of Morocco between 1997 and 2001 (Zaballos & Banda, 2000; Zaballos, 2005). In these campaigns abundant specimens of Typhlocharis (Coleoptera, Caraboidea, Trechidae) were collected in different localities, the majority of them belonging to the species T. armata Coiffait, 1969. Their study and the comparison with the type series of this species allowed its complete redescription and clarification of its status within the genus. Contrary to what has been considered traditionally, the marginal umbilicate series of elytra in T. armata is composed of three, instead of four posterior setae. The taxonomical affinities of this species are established, the morphological weight of the umbilicate group of elytral setae as a lineage and species group defining character is discussed, and the theory of Jeanne (1973) about the relation between shortening of elytra and umbilicate series reduction with a decrease in body size is revised. The dispersal abilities are evaluated and a biogeographical explanation for the new distribution of the species is proposed.Esta primera parte sobre las especies de Typhlocharis vicariantes del Estrecho de Gibraltar está dedicada a Typhlocharis armata Coiffait, 1969; mientras que en un segundo artículo se tratará T. silvanoides Dieck, 1869. El material estudiado procede de cuatro campañas entomológicas realizadas en el sur de España y en el norte de Marruecos entre 1997 y 2001 (Zaballos & Banda, 2000; Zaballos, 2005). En estas campañas se recolectaron, en localidades diferentes, abundantes ejemplares de Typhlocharis (Coleoptera, Caraboidea, Trechidae), la mayoría de los cuales han resultado pertenecer a la especie T. armata Coiffait, 1969. Su estudio y la consulta de la serie típica de la especie han permitido realizar una completa redescripción de la misma y aclarar su estatus dentro del género. Contrariamente a lo que se ha considerado tradicionalmente, la serie umbilicada marginal de los élitros de T. armata está formada por tres setas posteriores en vez de cuatro. Se establecen las nuevas afinidades taxonómicas de la especie, se discute el peso morfológico de la serie umbilicada de los élitros como carácter definitorio de los linajes y grupos de especies y se revisa la teoría de Jeanne (1973) que relaciona el acortamiento de los élitros y la reducción de la serie umbilicada con una disminución del tamaño corporal. Se valora la capacidad de dispersión de estos coleópteros y se propone una explicación biogeográfica para la nueva distribución de la especie

Introduction

L’étude des relations entre l’espace sacré et l’église médiévale n’est pas un sujet nouveau. Explorés dès les années 1960, entre autres, par les analyses pionnières de Carol Heitz à propos des liens entre architecture et liturgie à l’époque carolingienne, ces actes, issus du colloque tenu à Nanterre en juin 2018, entendent s’inscrire dans la lignée de ces travaux, tout en étendant la réflexion à d’autres supports artistiques tels que la sculpture, la peinture ou encore les objets d’art. Si, e..