The Problems of Rural Reindustrialization: A Case Study of Monroe, Massachusetts

Owing to the departure of the mill industry from rural New England, many small towns have suffered erosion of their economic base. These towns and villages face a declining population, vacant mills, and an aging work force. Monroe, Massachusetts, is an example of the problems of rural reindustrialization. This article concludes that state intervention is required for the restoration of productivity

Expression and Putative Function of Innate Immunity Genes under in situ Conditions in the Symbiotic Hydrothermal Vent Tubeworm Ridgeia piscesae

The relationships between hydrothermal vent tubeworms and sulfide-oxidizing bacteria have served as model associations for understanding chemoautotrophy and endosymbiosis. Numerous studies have focused on the physiological and biochemical adaptations that enable these symbioses to sustain some of the highest recorded carbon fixation rates ever measured. However, far fewer studies have explored the molecular mechanisms underlying the regulation of host and symbiont interactions, specifically those mediated by the innate immune system of the host. To that end, we conducted a series of studies where we maintained the tubeworm, Ridgeia piscesae, in high-pressure aquaria and examined global and quantitative changes in gene expression via high-throughput transcriptomics and quantitative real-time PCR (qPCR). We analyzed over 32,000 full-length expressed sequence tags as well as 26 Mb of transcript sequences from the trophosome (the organ that houses the endosymbiotic bacteria) and the plume (the gas exchange organ in contact with the free-living microbial community). R. piscesae maintained under conditions that promote chemoautotrophy expressed a number of putative cell signaling and innate immunity genes, including pattern recognition receptors (PRRs), often associated with recognizing microbe-associated molecular patterns (MAMPs). Eighteen genes involved with innate immunity, cell signaling, cell stress and metabolite exchange were further analyzed using qPCR. PRRs, including five peptidoglycan recognition proteins and a Toll-like receptor, were expressed significantly higher in the trophosome compared to the plume. Although PRRs are often associated with mediating host responses to infection by pathogens, the differences in expression between the plume and trophosome also implicate similar mechanisms of microbial recognition in interactions between the host and symbiont. We posit that regulation of this association involves a molecular “dialogue” between the partners that includes interactions between the host’s innate immune system and the symbiont

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

National Industrial Policy and the Local Planner

This article analyzes the debate concerning the problems, approaches, and intent of industrial policy as it relates to the working planner. It begins with a search for a definition. From there the authors set forth a rationale for such a policy and lay out the key characteristics typically proposed by its advocates. The critical dimensions in the debate are then reviewed. Finally, the potential impacts of various policy options upon local planners are discussed

The Role of Incubator Industries in the Local Economy: The Westfield, Massachusetts Experience

This study offers an analysis of the role of incubator industries in the local economy of Westfield, Massachusetts. It presents the results of a survey of 25 owners of small firms which have been in business for less than 10 years, have fewer than 20 employees, manufacture a product, and are registered as doing business in Westfield. The sample size represents approximately 90 percent of all firms in the City which fit the criteria noted above. It is recognized that the sample is quite small and that great care must be used in applying the recommendations to other communities. Yet, while this is simply a case study, it nevertheless serves to identify critical problems and to show how institutional and governmental actions can help to correct these problems. In terms of a contribution toward helping smaller municipalities to understand the needs of small businesses, this must be considered as a first step

Infrastructure Planning in Rural Massachusetts

This paper describes the importance of understanding and dealing with the problems of infrastructure planning and maintenance in rural communities. Infrastructure is defined to include roads, bridges, water and wastewater collection and treatment systems, and public buildings and capital equipment. The authors base their findings primarily on the experience of communities in Massachusetts, but these findings are readily applied to the situation of rural communities elsewhere in the U.S.A. and other developed countries. Three major conclusions are presented in the paper: the need for rural communities to develop long-range plans for infrastructure maintenance and finance; the need to develop effective local institutions to assume this responsibility, and the importance of managing growth in fast-growing rural areas in order to minimize the need for major expansion of infrastructure systems