32 research outputs found

    Challenges of Nutrition in Malaysia: Poverty, Land Appropriation, and Indigeneity

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    Malnutrition, especially in the form of wasting, stunting, and obesity, is disproportionately harming the Indigenous communities in Malaysia. Under the current legal system, Indigenous people receive little to no recognition and protection. Their land is often appropriated by the oil palm and dam industries, resulting in higher incidences of malnutrition and poverty. In order to improve the nutritional status of Malaysia as a whole, potential policies and programs include food fortification, crop diversification, and social safety nets. For the most marginalized communities, indigeneity and land restitution are analyzed as avenues to improve their livelihood

    Identifying adolescents' gaming preferences for a tobacco prevention social game: A qualitative study.

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    IntroductionConsidering the dangers of adolescent tobacco use, the successful design of behavioral programs is crucial for tobacco prevention. According to preliminary research, social game interventions can improve adolescent tobacco outcomes. The current qualitative study aims to (1) uncover the gaming elements that adolescents deem important for a positive learning experience, and (2) confirm these gaming elements with adolescents who are presented with a tobacco prevention game concept that applies these elements.MethodsFindings from this study are drawn from two phases. Phase 1 involved in-person focus group discussions (n = 15) and Phase 2 included three online focus groups and a paired interview with another set of adolescents (n = 15). The study was conducted under a project that aimed to design and test a social game-based tobacco prevention program for adolescents (Storm-Heroes). With open coding and thematic analysis, two research team members identified repeated topics and relevant quotes to organize them into themes. The themes evolved as new content was identified during the process. This process was repeated until thematic saturation was reached.ResultsThematic analysis across Phase 1 and Phase 2 revealed four major themes: 1) Balance during gaming challenges, 2) Healthy social interaction, 3) Performance and creative freedom, and 4) Fictional world and game mechanics for tobacco prevention.ConclusionThis study identified specific intervention features that best fit the needs of adolescents in the context of a social game for tobacco prevention. For future research, we will use a participatory approach to allow adolescents to take part in the design process, improve Storm-Heroes, and develop health promotional messages that can be incorporated into the program. Ultimately, a board game for tobacco prevention is expected to bring adolescents together to create lasting memories that nudge them away from tobacco use and the harm it can cause

    A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures

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    MicroRNAs (miRNAs) are important components of cellular signaling pathways, acting either as pathway regulators or pathway targets. Currently, only a limited number of miRNAs have been functionally linked to specific signaling pathways. Here, we explored if gene expression signatures could be used to represent miRNA activities and integrated with genomic signatures of oncogenic pathway activity to identify connections between miRNAs and oncogenic pathways on a high-throughput, genome-wide scale. Mapping >300 gene expression signatures to >700 primary tumor profiles, we constructed a genome-wide miRNA–pathway network predicting the associations of 276 human miRNAs to 26 oncogenic pathways. The miRNA–pathway network confirmed a host of previously reported miRNA/pathway associations and uncovered several novel associations that were subsequently experimentally validated. Globally, the miRNA–pathway network demonstrates a small-world, but not scale-free, organization characterized by multiple distinct, tightly knit modules each exhibiting a high density of connections. However, unlike genetic or metabolic networks typified by only a few highly connected nodes (“hubs”), most nodes in the miRNA–pathway network are highly connected. Sequence-based computational analysis confirmed that highly-interconnected miRNAs are likely to be regulated by common pathways to target similar sets of downstream genes, suggesting a pervasive and high level of functional redundancy among coexpressed miRNAs. We conclude that gene expression signatures can be used as surrogates of miRNA activity. Our strategy facilitates the task of discovering novel miRNA–pathway connections, since gene expression data for multiple normal and disease conditions are abundantly available

    Clinical Trial Transparency: The FDA Should and Can Do More

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    Research on Financial Web Sites Designed for Teenagers (Fall 2001) IPRO 359

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    The proliferation of the Internet in recent years has led to more people using, and being confused by, computer interfaces. Usability testing is a formal laboratory procedure used to identify problems with user interfaces during the development of a product. It involves creating tasks for users to accomplish and watching whether they can complete the given tasks. More importantly, the testers observe how users interact with the interface in an attempt to understand why they perform the actions they do. The testing allows developers to identify issues with their designs early enough in the product development cycle to be able to change them, saving money and resources later, in addition to creating an easier-to-use product. Unfortunately, many companies do not implement usability testing or do so too late into development to make any substantive changes suggested by the testing. The result is often a product that is needlessly hard to use. The team will conduct usability tests during the semester to gain first-hand experience in all aspects of usability testing. This project will test the interfaces of products produced by other IPROs and will work closely with other teams to identify and address issues arising from their work so that students on this team and others can appreciate the value of usability testing and designing with the end users in mind. A major focus of the team's work during the Fall 2001 semester will be to develop a business plan for the IIT Usability Testing and Evaluation Center (UTEC), and in particular to develop a marketing strategy for establishing UTEC as the Underwriter's Laboratory of the internet, whereby a web site authorized by UTEC to display the (UTEC) seal of approval will hold the distinction of having met minimum standards of usability for its intended user populations.Sponsorship: NAProject Plan for IPRO 359: Research on Financial Web Sites Designed for Teenagers for the Fall 2001 semeste

    Ethnic identification and relationship satisfaction in Chinese, Western, and intercultural Chinese-Western couples

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    Rates of international migration and intercultural marriage are rising. Migrants and intercultural partners may experience challenges in defining their ethnic identity relative to their own heritage culture, their partner's heritage culture, and the majority culture of their country of residence. The current study examined Chinese and Western ethnic identification and relationship satisfaction in four cultural combinations of couples: Western-Western (Western male-Western female), Chinese-Chinese (Chinese male-Chinese female), Western male-Chinese female, and Chinese male-Western female. All couples were residing in Brisbane, Australia, a multicultural city with a majority Western culture. Intracultural couples (Western-Western and Chinese-Chinese) reported the strongest ethnic identification with their heritage culture and weakest ethnic identification with their nonheritage culture, whereas intercultural couples (Western male-Chinese female and Chinese male-Western female) demonstrated intermediate identification. Greater similarity between partners on ethnic identification with the majority Western culture of Australia predicted greater relationship satisfaction, but there was no association of relationship satisfaction with partner similarity on Chinese ethnic identification. We discuss patterns of ethnic identification in terms of acculturation of immigrants, the selection of partners who are similar in ethnic identification, and accommodation of individuals' ethnic identification toward their partner's ethnic identification

    Ethnic identification and relationship satisfaction in Chinese, Western, and intercultural Chinese–Western couples

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    Rates of international migration and intercultural marriage are rising. Migrants and intercultural partners may experience challenges in defining their ethnic identity relative to their own heritage culture, their partner’s heritage culture, and the majority culture of their country of residence. The current study examined Chinese and Western ethnic identification and relationship satisfaction in four cultural combinations of couples: Western–Western (Western male–Western female), Chinese–Chinese (Chinese male–Chinese female), Western male–Chinese female, and Chinese male–Western female. All couples were residing in Brisbane, Australia, a multicultural city with a majority Western culture. Intracultural couples (Western–Western and Chinese–Chinese) reported the strongest ethnic identification with their heritage culture and weakest ethnic identification with their nonheritage culture, whereas intercultural couples (Western male–Chinese female and Chinese male–Western female) demonstrated intermediate identification. Greater similarity between partners on ethnic identification with the majority Western culture of Australia predicted greater relationship satisfaction, but there was no association of relationship satisfaction with partner similarity on Chinese ethnic identification. We discuss patterns of ethnic identification in terms of acculturation of immigrants, the selection of partners who are similar in ethnic identification, and accommodation of individuals’ ethnic identification toward their partner’s ethnic identification. (APA PsycInfo Database Record (c) 2019 APA, all rights reserved
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