5 research outputs found
Interconversion between a Vertically Oriented Transition Metal-Complexed Figure-of-Eight and a Horizontally Disposed One
A large ring containing two pairs
of transition metal-complexing fragments with alternating bi- and
tridentate chelates has been shown to behave as a bimodal figure-of-eight.
When coordinated to a preferentially octahedrally coordinated FeĀ(II)
or CuĀ(II) center, the height of the molecule along the coordinating
axis of the tridentate ligands (vertical on the drawing) is only ā¼11
Ć
, whereas the height of the molecule along the same vertical
axis is several times as large for the complex of the tetrahedrally
coordinated copperĀ(I) center. This new type of molecular machine-prototype
could be used as constitutive element in muscle-like dynamic systems
Copper(I)-Assembled [3]Rotaxane Whose Two Rings Act as Flapping Wings
A new copper-complexed [3]Ārotaxane consisting of two
coordinating
30-membered rings threaded by a two-binding-site axis has been prepared
in good yield from relatively simple organic fragments. The main specificity
of the system originates from the stoppering reaction, based on āclickā
chemistry, and thus from the presence of two triazole groups at positions
next to the bidentate chelates of the axis central part. The geometry
of the coordinating atoms belonging to the axis is such that the triazole
groups can either be part of the coordinating fragments when the metal
center is 5-coordinate or be not at all involved in coordination to
the metal when the latter is 4-coordinate. To be more specific, when
the two complexed metal centers are monovalent copperĀ(I) centers,
the triazoles are not included in the metal coordination sphere, whereas
when the metal centers are CuĀ(II) or Zn<sup>2+</sup>, the triazole
groups are bound to the metals. This is easily explained by the fact
that CuĀ(I) is preferably 4-coordinate and CuĀ(II) and Zn<sup>2+</sup> are 5-coordinate. The interconversion between both situations (4-
or 5-coordinate) can be quantitatively induced by metal exchange (CuĀ(I)/Zn<sup>2+</sup>) or by a redox process (CuĀ(II)/CuĀ(I)). It leads to important
geometrical changes and in particular to a strong modification of
the angle between the two rings. As a consequence, the two threaded
rings undergo a motion which is reminiscent of a wing-flapping movement
similar to that of birds. This flapping motion is fast and quantitative.
It should lead to new functional molecular machines in the future
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
RutheniumĀ(II)
polypyridyl complexes have emerged both as promising
probes of DNA structure and as anticancer agents because of their
unique photophysical and cytotoxic properties. A key consideration
in the administration of those therapeutic agents is the optimization
of their chemical reactivities to allow facile attack on the target
sites, yet avoid unwanted side effects. Here, we present a drug delivery
platform technology, obtained by grafting the surface of mesoporous
silica nanoparticles (MSNPs) with rutheniumĀ(II) dipyridophenazine
(dppz) complexes. This hybrid nanomaterial displays enhanced luminescent
properties relative to that of the rutheniumĀ(II) dppz complex in a
homogeneous phase. Since the coordination between the rutheniumĀ(II)
complex and a monodentate ligand linked covalently to the nanoparticles
can be cleaved under irradiation with visible light, the ruthenium
complex can be released from the surface of the nanoparticles by selective
substitution of this ligand with a water molecule. Indeed, the modified
MSNPs undergo rapid cellular uptake, and after activation with light,
the release of an aqua rutheniumĀ(II) complex is observed. We have
delivered, in combination, the rutheniumĀ(II) complex and paclitaxel,
loaded in the mesoporous structure, to breast cancer cells. This hybrid
material represents a promising candidate as one of the so-called
theranostic agents that possess both diagnostic and therapeutic functions
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
RutheniumĀ(II)
polypyridyl complexes have emerged both as promising
probes of DNA structure and as anticancer agents because of their
unique photophysical and cytotoxic properties. A key consideration
in the administration of those therapeutic agents is the optimization
of their chemical reactivities to allow facile attack on the target
sites, yet avoid unwanted side effects. Here, we present a drug delivery
platform technology, obtained by grafting the surface of mesoporous
silica nanoparticles (MSNPs) with rutheniumĀ(II) dipyridophenazine
(dppz) complexes. This hybrid nanomaterial displays enhanced luminescent
properties relative to that of the rutheniumĀ(II) dppz complex in a
homogeneous phase. Since the coordination between the rutheniumĀ(II)
complex and a monodentate ligand linked covalently to the nanoparticles
can be cleaved under irradiation with visible light, the ruthenium
complex can be released from the surface of the nanoparticles by selective
substitution of this ligand with a water molecule. Indeed, the modified
MSNPs undergo rapid cellular uptake, and after activation with light,
the release of an aqua rutheniumĀ(II) complex is observed. We have
delivered, in combination, the rutheniumĀ(II) complex and paclitaxel,
loaded in the mesoporous structure, to breast cancer cells. This hybrid
material represents a promising candidate as one of the so-called
theranostic agents that possess both diagnostic and therapeutic functions
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
RutheniumĀ(II)
polypyridyl complexes have emerged both as promising
probes of DNA structure and as anticancer agents because of their
unique photophysical and cytotoxic properties. A key consideration
in the administration of those therapeutic agents is the optimization
of their chemical reactivities to allow facile attack on the target
sites, yet avoid unwanted side effects. Here, we present a drug delivery
platform technology, obtained by grafting the surface of mesoporous
silica nanoparticles (MSNPs) with rutheniumĀ(II) dipyridophenazine
(dppz) complexes. This hybrid nanomaterial displays enhanced luminescent
properties relative to that of the rutheniumĀ(II) dppz complex in a
homogeneous phase. Since the coordination between the rutheniumĀ(II)
complex and a monodentate ligand linked covalently to the nanoparticles
can be cleaved under irradiation with visible light, the ruthenium
complex can be released from the surface of the nanoparticles by selective
substitution of this ligand with a water molecule. Indeed, the modified
MSNPs undergo rapid cellular uptake, and after activation with light,
the release of an aqua rutheniumĀ(II) complex is observed. We have
delivered, in combination, the rutheniumĀ(II) complex and paclitaxel,
loaded in the mesoporous structure, to breast cancer cells. This hybrid
material represents a promising candidate as one of the so-called
theranostic agents that possess both diagnostic and therapeutic functions