1 research outputs found
Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia
Through the development of a new
class of unnatural ornithine derivatives
as bioisosteres of arginine, we have designed an orally active peptidomimetic
antagonist of neuropeptide FF receptors (NPFFR). Systemic low-dose
administration of this compound to rats blocked opioid-induced hyperalgesia,
without any apparent side-effects. Interestingly, we also observed
that this compound potentiated opioid-induced analgesia. This unnatural
ornithine derivative provides a novel therapeutic approach for both
improving analgesia and reducing hyperalgesia induced by opioids in
patients being treated for chronic pain