1 research outputs found
Liposomes for PET and MR Imaging and for Dual Targeting (Magnetic Field/Glucose Moiety): Synthesis, Properties, and <i>in Vivo</i> Studies
We describe the potentiality of a
new liposomal formulation enabling
positron emission tomography (PET) and magnetic resonance MRĀ() imaging.
The bimodality is achieved by coupling a <sup>68</sup>Ga-based radiotracer
on the bilayer of magnetic liposomes. In order to enhance the targeting
properties obtained under a permanent magnetic field, a sugar moiety
was added in the lipid formulation. Two new phospholipids were synthesized,
one with a specific chelator of <sup>68</sup>Ga (DSPE-PEG-NODAGA)
and one with a glucose moiety (DSPE-PEG-glucose). The liposomes were
produced according to a fast and safe process, with a high radiolabeling
yield. MR and PET imaging were performed on mice bearing human glioblastoma
tumors (U87MG) after iv injection. The accumulation of the liposomes
in solid tumor is evidenced by MR imaging and the amount is evaluated <i>in vivo</i> and <i>ex vivo</i> according to PET imaging.
An efficient magnetic targeting is achieved with these new magnetic
liposomes