Régulation des taux d'angiotensine II tissulaires rénaux chez le rat

STRASBOURG-Sc. et Techniques (674822102) / SudocSudocFranceF

MALADIE HYPERTENSIVE DES POPULATIONS ORIGINAIRES D'AFRIQUE NOIRE (REVUE DE LA LITTERATURE ; ETUDE DE CAS)

STRASBOURG-Medecine (674822101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Risque médicamenteux : prévention

L'efficacité de la prévention d'un risque médicamenteux dépend de la précision avec laquelle ses facteurs déclenchants ou favorisants sont connus et de la qualité de l'information donnée à son sujet aux prescripteurs et aux utilisateurs. L'identification d'un risque devrait mettre à profit l'ensemble des données précliniques et cliniques disponibles pour la spécialité pharmaceutique considérée et les confronter aux données existantes pour des médicaments partageant un même mode d'action ou une même stratégie thérapeutique. L'information doit s'appuyer sur un plan de communication adapté au contexte de la pathologie traitée, des alternatives thérapeutiques existantes et du bénéfice attendu

Prevention of Drug-Induced Risks

Effective prevention of drug-induced risks depends on an accurate understanding of their triggering or predisposing factors, and the quality of information on these available to prescribing practitioners and users. All preclinical and clinical data available on the proprietary medicinal product concerned should facilitate identification of a risk, and these data should be compared with existing data on drugs sharing the same mode of action or therapeutic strategy. This information should be based on a communication plan adapted to the context of the disease under treatment, the therapeutic alternatives available and the benefits expected

Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT 4 receptor

International audienceWe have previously suggested that the recognition of a cross-reactive epitope on the 5-HT 4 receptor and the 52-kDa SSA/Ro protein by serotonin-antagonizing autoantibodies could explain the electrophysiological symptoms of congenital heart block in neonatal lupus. To confirm this hypothesis, we immunized female mice with four synthetic peptides corresponding to the recognized epitopes. All mice developed anti-peptide antibodies, which cross-reacted with the Ro52 and 5-HT 4 receptor peptides and recognized both cognate proteins. Peptide-immune mice were mated. The pups from mice immunized with the Ro52 peptides had no symptoms of neonatal lupus apart from bradycardia. However, pups from mice immunized with the 5-HT 4 receptor peptides and bradycardia, atrioventricular block of type I or II, longer QT intervals, skin rashes and neuromotoric problems. The 5-HT 4 receptor was detectable in the different fetal tissues affected (heart, skin and brain) by immunohistochemistry. Hearts from diseased pups were less developed and showed disorganized myocardial hyperplasia, compared to the normal littermates. These results demonstrate that the serotoninergic 5-HT 4 receptor is the antigenic target of physiopathological autoantibodies in neonatal lupus

Tolérance du peridopril dans l'hypertension arterielle. Résultats d'une étude multicentrique européenne

SCOPUS: cp.jinfo:eu-repo/semantics/publishe