Vivax malaria in Mauritania includes infection of a Duffy-negative individual

<p>Abstract</p> <p>Background</p> <p>Duffy blood group polymorphisms are important in areas where <it>Plasmodium vivax </it>is present because this surface antigen is thought to act as a key receptor for this parasite. In the present study, Duffy blood group genotyping was performed in febrile uninfected and <it>P. vivax</it>-infected patients living in the city of Nouakchott, Mauritania.</p> <p>Methods</p> <p><it>Plasmodium vivax </it>was identified by real-time PCR. The Duffy blood group genotypes were determined by standard PCR followed by sequencing of the promoter region and exon 2 of the Duffy gene in 277 febrile individuals. Fisher's exact test was performed in order to assess the significance of variables.</p> <p>Results</p> <p>In the Moorish population, a high frequency of the <it>FYB^ES/FYB^ES</it>genotype was observed in uninfected individuals (27.8%), whereas no <it>P. vivax</it>-infected patient had this genotype. This was followed by a high level of <it>FYA/FYB</it>, <it>FYB/FYB</it>, <it>FYB/FYB^ES</it>and <it>FYA/FYB^ES</it>genotype frequencies, both in the <it>P. vivax</it>-infected and uninfected patients. In other ethnic groups (Poular, Soninke, Wolof), only the <it>FYB^ES/FYB^ES</it>genotype was found in uninfected patients, whereas the <it>FYA/FYB^ES</it>genotype was observed in two <it>P. vivax</it>-infected patients. In addition, one patient belonging to the Wolof ethnic group presented the <it>FYB^ES/FYB^ES</it>genotype and was infected by <it>P. vivax</it>.</p> <p>Conclusions</p> <p>This study presents the Duffy blood group polymorphisms in Nouakchott City and demonstrates that in Mauritania, <it>P. vivax </it>is able to infect Duffy-negative patients. Further studies are necessary to identify the process that enables this Duffy-independent <it>P. vivax </it>invasion of human red blood cells.</p

Les Anticancéreux oraux à l'officine

TOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Prévention thérapeutique de l'Aspergillose invasive chez lez patients ayant subi une greffe allogénique de cellules souches hématopoïétiques

L'aspergillose invasive constitue un problème majeur chez les patients immuno-déprimés. Parmi ceux-ci, les patients subissant une greffe allogénique de cellules souches hématopoïétiques cumulent les facteurs de risques aspergillaires (Neutropénie, réaction du greffon contre l'hôte nécessitant une corticothérapie prolongée?). Le pronostic d'une telle infection est très mauvais pouvant atteindre 100% de mortalité dans certaines études. C'est pourquoi, une prophylaxie thérapeutique antifongique peut faire l'objet de discussion d'autant qu'elle n'est à ce jour pas recommandée du fait d'un nombre restreint d'études spécifiques. Nous avons choisi d'aborder ce problème et d'élaborer un consensus local afin de protéger pour le mieux les patients allogreffés susceptibles de développer une aspergillose invasive avec l'arsenal antifongique qui s'étoffe d'année en année.TOULOUSE3-BU Santé-Centrale (315552105) / SudocTOULOUSE3-BU Santé-Allées (315552109) / SudocSudocFranceF

Acquisition et mise en place d'un automate de contrôles analytiques des préparations injectables de cytotoxiques dans une unité de biopharmacie clinique oncologique (Impact qualité et conséquences sur l'organisation de l'unité)

TOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Etude de l'impact de l'utilisation de la formule MDRD pour l'estimation de la fonction rénale des patients traités par sels de platine au CHRU de Tours

TOURS-BU Sciences Pharmacie (372612104) / SudocSudocFranceF

Scheduling preparation of doses for a chemotherapy service

International audienceA fast realization of drugs is an important part in the quality of service of a hospital. In this paper we propose a scheduling method for the preparation of chemotherapy doses in order to reduce the patient waiting time. Two approaches have been defined: an off-line approach and a real time approach. The off-line approach is using a linear programming model for minimizing the maximum tardiness of jobs in a production day. This method is re-used during the real-time resolution combined with a greedy algorithm. The solution obtained respects constraints on the production center and the hospital organization. Our model is currently used in software which helps the decision maker of the service and allows increasing the patient satisfaction and the productivity of the service

Scheduling preparation of doses for a chemotherapy service

DOI 10.1007 /s10479-009-0624-2 http://www.springerlink.com/content/j15506t4m7377312/International audienceA fast realization of drugs is an important part in the quality of service of a hospital. In this paper we propose a scheduling method for the preparation of chemotherapy doses in order to reduce the patient waiting time. Two approaches have been defined: an off-line approach and a real time approach. The off-line approach is using a linear programming model for minimizing the maximum tardiness of jobs in a production day. This method is re-used during the real-time resolution combined with a greedy algorithm. The solution obtained respects constraints on the production center and the hospital organization. Our model is currently used in software which helps the decision maker of the service and allows increasing the patient satisfaction and the productivity of the service

Scheduling activities in a chemotherapy service

International audienc

Scheduling chemotherapy preparations with perishable raw materials constraints

International audienc

Planning and Tracking Chemotherapy Production for Cancer Treatment: a Performing and Integrated Solution

International audiencePurpose: Chemotherapy drugs are intended for the treatment of cancer. The production of such drugs and their administration to the patient is a delicate and expensive operation. The study deals with the acquisition and processing of data regarding the production of intravenous chemotherapy, from the production request (the medical prescription), the production itself (pharmaceutical process), to the delivery in the health care unit, for the administration of the chemotherapy. The goal of this study is to develop a system that can schedule, control and track the chemotherapy preparations and satisfy a certification process of quality management ("ISO 9001 version 2000" standard). Methods: The solution proposed in this paper was developed within the framework of a common certification process at the Biopharmaceutical Unit of the Oncology Clinic (UBCO) of the Bretonneau hospital in Tours (France). The system consists of two software programs: a software to insure traceability and a decision making software to plan the production. To simplify the data entry process, some mobile entry points with bar code reader have been deployed. These tools enable an accurate tracking of the production, a security and control for the schedule production phases, and a full traceability of each operation leading to the administration of the chemotherapy drug. Results: The first result is a software that creates the production schedule, allows a real time control of the production process and a full traceability of each step. Computational experiments are based on real data sets, with a comparison of a time period before and after the implementation of this solution. The results show the positive impacts of this software, like the reduction of delayed deliveries, real time generation of production indicators, optimization of the production and a saving of staff time. Conclusions: This intuitive system guarantees a traceability in connection with a high quality system certified ISO 9001-v2000 (with a rapid data entry), an assistant to schedule the production of preparations in a better way, a permanent follow-up and analysis of operations. This project proves the benefits of implementing computer solutions for the traceability and assistance in decision making in the hospital systems