Somatostatin and opioid receptors do not regulate proliferation or apoptosis of the human multiple myeloma U266 cells

International audienc

Mécanismes de régulation du récepteur opioïde delta humain dans le neuroblastome SK-N-BE

PARIS-BIUP (751062107) / SudocSudocFranceF

[Opioid tolerance: what if it was just a question of receptor internalization?].

Despite side effects which appear upon chronic administration of opioid agonists, these drugs remain widely used and effective for pain relief. Among these side effects, tolerance is the major factor limiting the effectiveness of these drugs. Desensitization, defined by a decrease of opioid receptor transduction, would be a crucial step in the development of tolerance. Molecular mechanisms of opioid receptor desensitization have been extensively studied on cellular models and have been found to involve various proteins and different steps such as receptor phosphorylation, internalization, and recycling or degradation into intracellular compartments. In the present review, we discuss the role of opioid receptor internalization and sorting in desensitization and tolerance processes

Etude du rôle des b-arrestines dans la régulation différentielle des récepteurs opioïdes delta dans le neuroblastome humain SK-N-B E

CAEN-BU Médecine pharmacie (141182102) / SudocSudocFranceF

Mécanismes impliqués dans la régulation des MAP kinases par les récepteurs opioïdes delta

CAEN-BU Médecine pharmacie (141182102) / SudocSudocFranceF

Differential desensitization of human δ-opioid receptors by peptide and alkaloid agonists

International audienc

Differential Sorting of Human δ-Opioid Receptors after Internalization by Peptide and Alkaloid Agonists

International audienc

Different Regulation of Human -Opioid Receptors by SNC-80 [(+)-4-[( R)- -((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and Endogenous Enkephalins

International audienc