Characteristics of patients with septic arthritis ED visits who were hospitalized compared to those not hospitalized.

<p>Characteristics of patients with septic arthritis ED visits who were hospitalized compared to those not hospitalized.</p

Descriptive statistics for utilization and charges for hospitalizations with septic arthritis.

<p>Descriptive statistics for utilization and charges for hospitalizations with septic arthritis.</p

Predictors of the duration of hospital stay among patients with septic arthritis hospitalized with septic arthritis after presenting to the ER.

<p>Predictors of the duration of hospital stay among patients with septic arthritis hospitalized with septic arthritis after presenting to the ER.</p

Disposition of patients after hospital admission for septic arthritis.

<p>Disposition of patients after hospital admission for septic arthritis.</p

Predictors of discharge to home among patients who had a hospital admission with septic arthritis after presenting to ER.

<p>Predictors of discharge to home among patients who had a hospital admission with septic arthritis after presenting to ER.</p

Sensitivity analyses of multivariable-adjusted association of diabetes with moderate-severe ADL limitation at 2- and 5-years

a<p>Adjusted the main multivariable model for anxiety and depression, i.e. the model is adjusted for a total of 11 additional covariates/confounders: Age, gender, BMI, Deyo-Charlson comorbidity score, ASA class, distance from the medical center, income, underlying diagnosis, preoperative moderate-severe ADL limitation, anxiety and depression</p>b<p>Adjusted the main multivariable model for anxiety, depression and ipsilateral hip pain, i.e. the model is adjusted for a total of 12 additional covariates/confounders: Age, gender, BMI, Deyo-Charlson comorbidity score, ASA class, distance from the medical center, income, underlying diagnosis, preoperative moderate-severe ADL limitation, anxiety, depression and ipsilateral hip involvement</p>c<p>Adjusted the main multivariable model for anxiety and depression, but not for Deyo-Charlson, i.e. the model is adjusted for a total of 8 additional covariates/confounders: Age, gender, BMI, ASA class, distance from the medical center, income, underlying diagnosis, preoperative moderate-severe ADL limitation</p

Gout and the risk of age-related macular degeneration in the elderly

<div><p>Objective</p><p>To assess whether gout is associated with incident age-related macular degeneration (AMD)</p><p>Methods</p><p>We used the 5% Medicare claims data from 2006–12 for all beneficiaries who were enrolled in Medicare fee-for-service (Parts A, B) and not enrolled in a Medicare Advantage Plan, and resided in the U.S. People were censored at the occurrence of new diagnosis of AMD, death or the end of study (12/31/2012), whichever occurred first. We used multivariable-adjusted Cox regression analyses to assess the association of gout with incident AMD, adjusted for demographics, comorbidity, and use of medications for cardiovascular disease and gout. Hazard ratios and 95% confidence intervals were calculated.</p><p>Results</p><p>In this observational cohort study, of the 1,684,314 eligible people, 116,097 developed incident AMD (6.9%). Incidence rates of AMD per 1,000 person-years were 20.1 for people with gout and 11.7 for people without gout. In multivariable-adjusted analyses, a diagnosis of gout was significantly associated with a higher risk of incident AMD with a hazard ratio of 1.39 (95% CI, 1.35, 1.43). This association was confirmed in sensitivity analyses that substituted Charlson-Romano comorbidity index continuous score with either a categorical Charlson-Romano comorbidity index score or individual Charlson-Romano index comorbidities plus hypertension, hyperlipidemia and coronary artery disease. Other covariates significantly associated with higher hazards of incident AMD were older age, female gender, White race/ethnicity, and higher Charlson-Romano comorbidity index score.</p><p>Conclusions</p><p>We noted a novel association of gout with AMD in the elderly. Future studies should investigate the pathways that mediate this association.</p></div

Diabetes: A Risk Factor for Poor Functional Outcome after Total Knee Arthroplasty

<div><p>Background</p><p>To assess the association of diabetes with postoperative limitation of activities of daily living (ADLs) after primary total knee arthroplasty (TKA).</p><p>Methodology/Principal Findings</p><p>We used the prospectively collected data from the Mayo Clinic Total Joint Registry to assess the association of diabetes and diabetes with complications with moderate-severe ADL limitation 2- and 5-years after primary TKA. Multivariable logistic regression with general estimating equations adjusted for preoperative ADL limitation, comorbidity and demographic and clinical covariates. Odds ratio (OR) and 95% confidence interval (CI) are presented. 7,139 primary TKAs at 2-years and 4,234 at 5-years constituted the cohorts. In multivariable-adjusted analyses, diabetes was associated with higher odds of moderate-severe limitation at 2- and 5-years, 1.71 (95% CI: 1.26, 2.32; <i>P = </i>0.001) and 1.66 (95% CI: 1.13, 2.46; <i>P = </i>0.01). Respective ORs for patients with diabetes with complications were 2.73 (95% CI: 1.47, 5.07; <i>P = </i>0.001) and 2.73 (95% CI: 1.21, 6.15; <i>P = </i>0.016). Sensitivity analyses that adjusted for anxiety and depression or anxiety, depression and ipsilateral hip involvement showed minimal attenuation of magnitude of the association.</p><p>Conclusions/Significance</p><p>In this large study of patients who underwent primary TKA, diabetes as well as its severity were independently associated with poorer functional outcome. Given the increasing rates of both diabetes as well as arthroplasty, more insight is needed into disease-related and treatment-related factors that underlie this higher risk of ADL limitation in patients with diabetes. Poor functional outcomes may be preventable by modifying the control of diabetes and associated comorbidity in pre- and post-arthroplasty periods.</p></div

Crude incidence rate of age-related macular degeneration (AMD) by the presence of gout at baseline.

<p>Crude incidence rate of age-related macular degeneration (AMD) by the presence of gout at baseline.</p

Association of gout and other risk factors with age-related macular degeneration (AMD).

<p>Association of gout and other risk factors with age-related macular degeneration (AMD).</p