Number of common biospecimens (≥ 10) used to derive unique assay data.

<p>Number of common biospecimens (≥ 10) used to derive unique assay data.</p

Imported digital data within High Dimensional Database platform available for <i>in silico</i> research.

<p>Imported digital data within High Dimensional Database platform available for <i>in silico</i> research.</p

Representative Venn diagrams of shared and overlapping biospecimens used to derive unique assay data (pairs, trios, or quartets) from divergent investigations.

<p>Representative Venn diagrams of shared and overlapping biospecimens used to derive unique assay data (pairs, trios, or quartets) from divergent investigations.</p

Proposed workflow for continued population of HDD with new digital datasets derived from voluntary sharing of research results provided by principal investigators utilizing exhaustible biospecimens.

<p>Proposed workflow for continued population of HDD with new digital datasets derived from voluntary sharing of research results provided by principal investigators utilizing exhaustible biospecimens.</p

Osteosarcoma enters a post genomic era with <i>in silico</i> opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation - Fig 2

<p>(A) Heat map showing the RNA expression of 3 genes C4orf3, USP9Y, and DDX3Y inversely correlated with circulating concentrations of IGFBP2. (B) Unsupervised hierarchal clustering analysis of gene expression profiles of the primary tumors based upon quartile circulating IGFBP2 concentrations. (C) The plot of primary tumor IGFBP2 mRNA expressions against circulating IGFBP2 concentrations of the matched samples.</p

Additional file 1 of Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial

Additional file 1: Table S1. Cell lines and mice models established. A total of 96 patients enrolled onto the NMTRC009 MGT trial had at least one tumor cell line generated in the laboratory setting. Since many subjects underwent multiple tumor biopsies and/or bone marrow biopsies, subjects may have >1 unique cell line, either from the same tumor obtained from different biopsy dates or from a different disease site (bone marrow). 47 subjects’ tumors underwent successful implantation into a NOD-SCID mouse to generate at least one PDX model. A total of 56 unique PDX models were generated