4 research outputs found
Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians – a cross-sectional study
Methods A cross-sectional study was conducted to genotype 1028 healthy blood
donors and 1517 clinically well characterized elderly for CETP I405V. Results
We could not find any association of this polymorphism with age for both,
males or females, in any of these cohorts (P = 0.71 and P = 0.57,
respectively, for males and P = 0.55 and P = 0.88, respectively, for females).
In addition, no association with cardiovascular diseases could be observed in
the elderly cohort (males OR = 1.12 and females OR = 0.88). In the same
cohort, the CETP V405V genotype was associated with significantly enhanced HDL
levels (P = 0.03), mostly owing to the female sex (P = 0.46 for males, P =
0.02 for females), whereas LDL and triglyceride levels were unchanged (P =
0.62 and P = 0.18, respectively). Conclusion Our data support the recent
hypothesis that variations enhancing HDL levels without affecting LDL levels
are not associated with the risk for cardiovascular diseases
TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study
Background To investigate mechanisms that determine healthy aging is of major
interest in the modern world marked by longer life expectancies. In addition
to lifestyle and environmental factors genetic factors also play an important
role in aging phenotypes. The aged immune system is characterized by a chronic
micro-inflammation, known as inflamm-aging, that is suspected to trigger the
onset of age-related diseases such as cardiovascular disease, Alzheimer’s
disease, cancer, and Diabetes Mellitus Type 2 (DMT2). We have recently shown
that a Toll-like receptor 6 variant (P249S) is associated with susceptibility
to cardiovascular disease and speculated that this variant may also be
associated with healthy aging in general by decreasing the process of inflamm-
aging. Results Analyzing the PolSenior cohort we show here that nonsmoking S
allele carriers are significantly protected from age-related diseases (P =
0.008, OR: 0.654). This association depends not only on the association with
cardiovascular diseases (P = 0.018, OR: 0.483) for homozygous S allele
carriers, but is also driven by a protection from Diabetes Mellitus type 2 (P
= 0.010, OR: 0.486) for S allele carriers. In addition we detect a trend but
no significant association of this allele with inflamm-aging in terms of
baseline IL-6 levels. Conclusion We confirm our previous finding of the TLR-6
249S variant to be protective regarding cardiovascular diseases. Furthermore,
we present first evidence of TLR-6 249S being involved in DMT2 susceptibility
and may be in general associated with healthy aging possibly by reducing the
process of inflamm-aging