Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents

ABSTRACT We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the concentration versus time curve from 0 to 24 h were 0.74 μg/ml (0.61 μg/ml) and 9.28 μg · h/ml (6.30 μg · h/ml), respectively. The exposure and safety in this small cohort of adolescents were comparable to those for adults. (This study has been registered at ClinicalTrials.gov under registration no. NCT01966055.

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

Stability Of An Ellipsoidal Head With A Central Nozzle Under Axial Load

The subject of the numerical investigation is an ellipsoidal head with a central (axis-symmetrical) nozzle. The nozzle is loaded by axial load force. The ellipsoidal head is under axial-symmetrical compression load. The numerical FEM model is elaborated. The calculation will provide the critical loads and equilibrium paths for the sample head.. The investigation will measure the influence of the diameter of the nozzle on the critical state of the ellipsoidal head

Marszczenie ściskanej okładziny belki trójwarstwowej poddanej czystemu zginaniu

The paper is devoted to sandwich beams under pure bending. The local buckling problem is analysed. The analytical description of the upper face wrinkling is proposed. From the principle of stationary total potential energy, formulae describing critical stresses in the faces of the beam are derived. The algorithm for determining the critical stresses is shown. Two particular cases of the solution following the core properties are mentioned. The finite element model of the sandwich beam is formulated. The comparison of the results obtained from the proposed analytical model and from FEM analysis is shown for a family of sandwich beams with different thicknesses and core properties.W pracy omówiono zagadnienie lokalnej stateczności belki trójwarstwowej poddanej czystemu zginaniu. Zaproponowano analityczny model marszczenia górnej, ściskanej okładziny. Z zasady stacjonarności energii potencjalnej wyprowadzono równanie opisujące naprężenia krytyczne. Zaproponowano algorytm pozwalający określić wartość naprężeń krytycznych w zależności od własności rdzenia. Opracowano model numeryczny MES belki trójwarstwowej. Dla rodziny belek przeprowadzono analizę numeryczną na wartości własne, a wyniki porównano z otrzymanymi z zaproponowanego modelu analitycznego

Stateczność dna elipsoidalnego z króćcem środkowym pod obciążeniem osiowym

The subject of the numerical investigation is an ellipsoidal head with a central (axis-symmetrical) nozzle. The nozzle is loaded by axial load force. The ellipsoidal head is under axial-symmetrical compression load. The numerical FEM model is elaborated. The calculation will provide the critical loads and equilibrium paths for the sample head. The investigation will measure the influence of the diameter of the nozzle on the critical state of the ellipsoidal head.Praca poświęcona jest analizie stateczności dna elipsoidalnego będącego typowym elementem zbiorników ciśnieniowych. Dno zakończone jest króćcem obciążonym siłą osiową ściskającą lub rozciągającą. Przeanalizowano wpływ średnicy króćca na wartość obciążenia krytycznego, postać wyboczenia oraz na przebieg ścieżki równowagi dna