Risk of developing ACPA-positive or ACPA-negative RA among carriers of SE (single, double or any) in the MyEIRA study population by ethnicity.

<p>*Cases and controls without SE genes were used as reference groups.</p><p>**Fisher exact two-tailed p value, p = 0.0015.</p><p>#Fisher exact two-tailed p value, p = 0.3, NS.</p

Baseline demographic characteristics of cases of rheumatoid arthritis (RA) and controls in MyEIRA, by ethnicity.

<p>RF: rheumatoid factor, ACPA: anti-citrullinated proteins antibody, SE: shared epitope.</p><p>*patients and controls carrying one or two alleles of shared epitope were classified as SE-positive.</p><p>The percentages calculated in each characteristic category were based on the number of available data.</p

Carrier frequencies of HLA-DRB1in the Malay ethnic group by ACPA status.

<p>*The frequency of DRB1 genotypes in ACPA subgroups was calculated as the number of ACPA-positive or ACPA-negative RA cases for a specific DRB1 allele divided by the total number of cases within that ACPA subgroup (Malay: 256 ACPA-positive RA cases and 149 ACPA-negative RA cases).</p><p>§Individuals without the allele being investigated were used as the reference group for the calculation of odds ratio (OR) and 95% confidence interval (95% CI).</p><p>Corrected p (p_c) values were obtained by multiplying the uncorrected p values by 13.</p><p>NS: not significant.</p

Carrier frequencies of HLA-DRB1in the Chinese ethnic group by ACPA status.

<p>*The frequency of DRB1 genotypes in ACPA subgroups was calculated as the number of ACPA-positive or ACPA-negative RA cases for a specific DRB1 allele divided by the total number of cases within that ACPA subgroup (Chinese: 132 ACPA-positive RA cases and 72 ACPA-negative RA cases).</p><p>§Individuals without the allele being investigated were used as the reference group for the calculation of odds ratio (OR) and 95% confidence interval (95% CI).</p><p>Corrected p (p_c) values were obtained by multiplying the uncorrected p values by 13.</p><p>NS: not significant.</p

Carrier frequencies of HLA-DRB1in the Indian ethnic group by ACPA status.

<p>*The frequency of DRB1 genotypes in ACPA subgroups was calculated as the number of ACPA-positive or ACPA-negative RA cases for a specific DRB1 allele divided by the total number of cases within that ACPA subgroup (Indian: 200 ACPA-positive RA cases and 96 ACPA-negative RA cases).</p><p>§Individuals without the allele being investigated were used as the reference group for the calculation of odds ratio (OR) and 95% confidence interval (95% CI).</p><p>Corrected p (p_c) values were obtained by multiplying the uncorrected p values by 13.</p><p>NS: not significant.</p