4,011 research outputs found
Differences between European birthweight standards: impact on classification of ‘small for gestational age’
We describe a quantitative and comparative review of a selection of European birthweight standards for gestational age for singletons, to enable appropriate choices to be made for clinical and research use. Differences between median values at term across standards in 10 regions and misclassification of ‘small for gestational age’ (SGA), were studied. Sex and parity differences, exclusion criteria, and methods of construction were considered. There was wide variation between countries in exclusion criteria, methods of calculating standards, and median birthweight at term. The lightest standards (e.g. France's medians are 255g lower than Norway's medians) were associated with fewer exclusion criteria. Up to 20% of the population used in the construction of the Scottish standard would be classified as SGA using the Norwegian standard. Substantial misclassification of SGA is possible. Assumptions about variation used in the construction of some standards were not justified. It is not possible to conclude that there are real differences in birthweight standards between European countries. Country-based standards control for some population features but add misclassification due to the differing ways in which standards are derived. Standards should be chosen to reflect clinical or research need. If standards stratified by sex or parity are not available, adjustments should be made. In multinational studies, comparisons should be made between results using both a common standard and country-based standards
A Comparison of Low Read Depth QuantSeq 3 ' Sequencing to Total RNA-Seq in FUS Mutant Mice
Transcriptomics is a developing field with new methods of analysis being produced which may hold advantages in price, accuracy, or information output. QuantSeq is a form of 3′ sequencing produced by Lexogen which aims to obtain similar gene-expression information to RNA-seq with significantly fewer reads, and therefore at a lower cost. QuantSeq is also able to provide information on differential polyadenylation. We applied both QuantSeq at low read depth and total RNA-seq to the same two sets of mouse spinal cord RNAs, each comprised by four controls and four mutants related to the neurodegenerative disease amyotrophic lateral sclerosis. We found substantial differences in which genes were found to be significantly differentially expressed by the two methods. Some of this difference likely due to the difference in number of reads between our QuantSeq and RNA-seq data. Other sources of difference can be explained by the differences in the way the two methods handle genes with different primary transcript lengths and how likely each method is to find a gene to be differentially expressed at different levels of overall gene expression. This work highlights how different methods aiming to assess expression difference can lead to different results
15 mev proton emission from jet plasmas exhibiting sawtooth behaviour: results and interpretation
The KHOLOD Experiment: A Search for a New Population of Radio Sources
Published data from long-term observations of a strip of sky at declination
+5 degrees carried out at 7.6 cm on the RATAN-600 radio telescope are used to
estimate some statistical properties of radio sources. Limits on the
sensitivity of the survey due to noise imposed by background sources, which
dominates the radiometer sensitivity, are refined. The vast majority of noise
due to background sources is associated with known radio sources (for example,
from the NVSS with a detection threshold of 2.3 mJy) with normal steep spectra
({\alpha} = 0.7-0.8, S \propto {\nu}^{- \alpha}), which have also been detected
in new deep surveys at decimeter wavelengths. When all such objects are removed
from the observational data, this leaves another noise component that is
observed to be roughly identical in independent groups of observations. We
suggest this represents a new population of radio sources that are not present
in known catalogs at the 0.6 mJy level at 7.6 cm. The studied redshift
dependence of the number of steep-spectrum objects shows that the sensitivity
of our survey is sufficient to detect powerful FRII radio sources at any
redshift, right to the epoch of formation of the first galaxies. The inferred
new population is most likely associated with low-luminosity objects at
redshifts z < 1. In spite of the appearance of new means of carrying out direct
studies of distant galaxies, searches for objects with very high redshifts
among steep and ultra-steep spectrum radio sources remains an effective method
for studying the early Universe.Comment: 13 pages, 10 figure
Polynomial super-gl(n) algebras
We introduce a class of finite dimensional nonlinear superalgebras providing gradings of . Odd generators close by anticommutation on polynomials (of
degree ) in the generators. Specifically, we investigate `type I'
super- algebras, having odd generators transforming in a single
irreducible representation of together with its contragredient.
Admissible structure constants are discussed in terms of available
couplings, and various special cases and candidate superalgebras are identified
and exemplified via concrete oscillator constructions. For the case of the
-dimensional defining representation, with odd generators , and even generators , , a three
parameter family of quadratic super- algebras (deformations of
) is defined. In general, additional covariant Serre-type conditions
are imposed, in order that the Jacobi identities be fulfilled. For these
quadratic super- algebras, the construction of Kac modules, and
conditions for atypicality, are briefly considered. Applications in quantum
field theory, including Hamiltonian lattice QCD and space-time supersymmetry,
are discussed.Comment: 31 pages, LaTeX, including minor corrections to equation (3) and
reference [60
Unexpected Features of Supersymmetry with Central Charges
It is shown that N=2 supersymmetric theories with central charges present
some hidden quartic symmetry. This enables us to construct representations of
the quartic structure induced by superalgebra representations.Comment: 14 pages, more details have been given, to appear in J. Phys.
Nanostructure of cellulose microfibrils in spruce wood
The structure of cellulose microfibrils in wood is not known in detail, despite the abundance of cellulose in woody biomass and its importance for biology, energy, and engineering. The structure of the microfibrils of spruce wood cellulose was investigated using a range of spectroscopic methods coupled to small-angle neutron and wide-angle X-ray scattering. The scattering data were consistent with 24-chain microfibrils and favored a “rectangular” model with both hydrophobic and hydrophilic surfaces exposed. Disorder in chain packing and hydrogen bonding was shown to increase outwards from the microfibril center. The extent of disorder blurred the distinction between the I alpha and I beta allomorphs. Chains at the surface were distinct in conformation, with high levels of conformational disorder at C-6, less intramolecular hydrogen bonding and more outward-directed hydrogen bonding. Axial disorder could be explained in terms of twisting of the microfibrils, with implications for their biosynthesis
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