Regina Hewitt, ed., John Galt: Observations and Conjectures

Review of collection of scholarly essays on the Scottish novelist and poet John Galt (1779-1839), who was also a pioneer in Canadian fiction

Investigating the Physical Stability of Amorphous Pharmaceutical Formulations

Amorphous formulations, including amorphous solid dispersions (ASDs), consisting of the active pharmaceutical ingredient (API) intimately mixed in a polymeric matrix, are an attractive formulation approach to improve drug delivery, dissolution, and solubility. However, an amorphous API in an ASD is in a higher energy state compared to the crystalline drug and results in most ASDs being inherently unstable. The polymer helps to stabilize the amorphous drug against crystallization such that the resulting homogenous mixture maintains its solubility advantage relative to the crystalline form. One challenge of ASDs is that the presence of impurities including crystals or residual solvent, variations in the ingredients, or changes in storage conditions can all affect physical stability and bioavailability. There is a clear need for advanced analytical techniques that can both detect, characterize, and quantify the components of amorphous formulations, especially ASDs. This research focuses on methods to detect and quantify crystallinity, ensure consistency between manufactured lots of amorphous formulations, and predict shelf life and drug substance properties. Poorly soluble model drug compounds such as nifedipine, indomethacin, and patiromer were studied using multiple analytical techniques including solid-state nuclear magnetic resonance (SSNMR) spectroscopy. First, SSNMR was used to develop a method to quantify the monomeric makeup of an insoluble polymeric API which can be used to demonstrate API sameness during generic drug development. Second, crystallinity was detected, quantified, and compared using a variety of analytical techniques with SSNMR and powder X-ray diffraction being used to predict drug-polymer solubility form the first time. Third, an extensive investigation into the effect of hydrogen bonding, drug loading, and storage temperature on crystallization tendency was conducted around the glass transition temperature (Tg) and found that hydrogen bonding plays a particularly important role in stability near Tg. Lastly, the impact of multiple absorbed solvents on the physicochemical properties of pharmaceutical polymers was investigated using dynamic vapor sorption. In conclusion, this research proposes new methods and new applications of existing analytical techniques for the advanced characterization of pharmaceutical amorphous formulations. The results provide an improved understanding of the factors affecting the physical stability of ASDs and should aid in their successful formulation

The Effect of Quercetin-3-B-Rutinoside on Blood Coagulation and the Development of Atherosclerotic Lesions in Swines

A thesis presented to the faculty of the School of Sciences and Mathematics at Morehead State University in partial fulfillment of the requirements for the Degree on Master of Science in Biology by Milford C. Jarrells on May 8, 1979

Preface to SSL 47.1

Introduces the issue contents, pays brief tribute to six long-time Scottish literature scholars who have recently died (Michael Timko, Priscilla Bawcutt, Greg Kratzmann, Robert Donaldson, Thorne Compton, and Dorothy McMillan), notes that the journal has now surpassed 400,000 article downloads, and describes plans for forthcoming issues

Preface to SSL 48.2

Discusses the range of periods the journal covers, introduces current contents, pays brief tribute to the Hume scholar Donald T. Siebert and the Burns collector Frank R. Shaw, and alerts readers to editorial and publishing changes to be announced in the coming year

Series Editors\u27 Preface to SSL 48.1

A brief introduction with thanks to the guest editors, information about the cover illustration for the print issue, by John Duncan (1866-1945), and a note of plans for future issues

Preface to SSL 46.1

Introducing the issue, with brief tributes to three Scottish literature scholars who died in summer 2020: Colin Manlove, Aileen Christianson, and Douglas Gifford

Introduction: Cultural Nationalism in Scottish Literary Studies: the View from Elsewhere

Introduces the issues and contributors to this post-Referendum SSL symposium, on non-Scottish perspectives on Scottish cultural nationalism, which includes discussions of teaching Scottish literature in Italy, Germany, the United Arab Emirates, and the United States, together with a response from a senior Scottish scholar, notes the interest elsewhere in contemporary Scottish writing, and suggests that the effect of the debates surrounding the Referendum, and the involvement of many writers in it, will have a continuing effect on the future of Scottish literary studies

Introduction: A Glorious Phantom: Insurrections in Scottish Literature

Introduces the SSL symposium on Insurrections by tracing themes from James Kelman\u27s play Hardie and Baird: the Last Days (1978), about the Scottish Insurrection of 1820