3 research outputs found
Examining the Impact of Professional Learning Communities on School Performance
Implementing the principles of a professional learning community (PLC) in public schools has become a popular strategy for meeting school quality and accountability expectations. Whether PLC implementation results in improved school ratings represents a gap in the literature. Three out of the 4 elementary schools in the participating school district experienced a significant drop in state ratings. The purpose of this quantitative study was to explore the relationship between the perceived depth of implementaiton of PLCs and a school\u27s performance in terms of state ratingsGuided by the theory of the learning organization, this quantitative study was designed to identify the extent to which participants believed their schools operate as PLCs and to determine whether there is a significant difference in results between the participating schools. Participant perceptions of PLC implementation were measured through the Professional Learning Communities Assessment-Revised survey instrument. A total of 77 teachers across the 4 schools participated, and descriptive statistics were used to measure the level of PLC implementation. A one-way ANOVA was conducted to determine if there was significant differences in responses from the schools. The ANOVA revealed no significant differences in the responses between the school that did not experience a drop in ratings and the other schools. The results of this study could provide a framework to aid teachers and administrators to improve student learning by providing improved instruction. Quality instruction can lead to improved student learnings, and when student outcomes are improved, more students graduate and become productive members of their communities
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Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients.
•Early alemtuzumab allowed early immune recovery despite immune ablation.•Systemic infections similarly tracked immune reconstitution.•Infection patterns were similar after related and unrelated transplants.
Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for many nonmalignant disorders (NMD) and is curative or prevents disease progression. Reduced-intensity conditioning (RIC) in HSCT for NMD may reduce regimen-related acute toxicities and late complications. Myeloablation is often replaced by immune suppression in RIC regimens to support donor engraftment. The pace of immune reconstitution after immune suppression by RIC regimens is influenced by agents used, donor source, and graft-versus-host disease prophylaxis/treatment. In a multicenter trial (NCT 00920972) of HSCT for NMD, a RIC regimen consisting of alemtuzumab, fludarabine, and melphalan was substituted for myeloablation. Alemtuzumab was administered early (days −21 to −19) to mitigate major lymphodepletion of the incoming graft and the risk of graft rejection. Immune reconstitution and infectious complications were prospectively monitored for 1-year post-HSCT. Seventy-one patients met inclusion criteria for this report and received marrow or peripheral blood stem cell transplants. Immune reconstitution and infections are reported for related donor (RD) and unrelated donor (URD) transplants at 3 time-points (100days, 6 months, and 1 year post-HSCT). Natural killer cell recovery was rapid, and numbers normalized in both cohorts by day +100. Mean CD3, CD4, and CD8 T-lymphocyte numbers normalized by 6 months after RD HSCT and by 1 year in the URD group. CD4 and CD8 T-lymphocyte counts were significantly higher in patients who received RD HSCT at 6 months and at 1 year, respectively, post-HSCT compared with patients who received URD HSCT. The pace of CD19 B-cell recovery was markedly different between RD and URD cohorts. Mean B-cell numbers were normal by day 100 after RD HSCT but took 1 year post-HSCT to normalize in the URD cohort. Despite these differences in immune reconstitution, the timing and nature of infections did not differ between the groups, presumably because of comparable T-lymphocyte recovery. Immune reconstitution occurred at a faster pace than in prior reports using RIC with T-cell depletion. The incidence of infections was similar for both cohorts and occurred most frequently in the first 100days post-HSCT. Viral and fungal infections occurred at a lower incidence in this cohort, with “early” alemtuzumab compared with regimens administering serotherapy in the peritransplantation period. Patients were susceptible to bacterial infections primarily in the first 100days irrespective of donor source and had no increase in mortality from the same. The overall mortality rate from infections was 1.4% at 1 year. Close monitoring and prophylaxis against bacterial infections in the first 100days post-HSCT is necessary but is followed by robust immune reconstitution, especially in the T-cell compartment