Suicide Attempt by Pacemaker System Abuse: A Case Report with Comments on the Psychological Adaptation of Pacemaker Patients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72997/1/j.1540-8159.1980.tb04333.x.pd

Leaving no one behind: Urban poverty traps in Sub-Saharan Africa

Despite considerable achievements in the reduction of poverty over the last decades, poverty remains conspicuously high and profound. While fast urban population growth, especially in Sub-Saharan Africa, has contributed to poverty reduction, new development challenges like the urbanisation of poverty emerge. However, little is known about the state and persistence of poverty in urban areas. This study investigates urban poverty within the theory of poverty traps among urban households in Nigeria, Tanzania and Ethiopia, three countries in Sub-Saharan Africa with large urban populations and fast urban population growth. Using household panel data from the World Bank's Living Standard Measurement Study between 2008 and 2015, we test whether consumption-based poverty traps exist in these contexts. Our results show that initially poor households experience an increase in well-being over time, while richer households face a decline and remain vulnerable to falling back into poverty. As households converge to consumption levels around the $3.20 poverty line, there is considerable movement into and out of poverty over time. However, a sticky consumption floor shows that despite upward dynamics amongst the poor, some are being left behind. Finally, we argue that improved urban data is needed to identify the vulnerable middle, and to design structural policies preventing them from falling back into poverty

Physical Activity in Childhood May Be the Key to Optimizing Lifespan Skeletal Health

Physical activities undertaken in childhood, particularly activities which apply large forces quickly convey optimal benefits to bone mass, size, and structure. Evidence is accumulating that benefits persist well beyond activity cessation. This review examines the potential for early childhood activity to improve bone mineralization and structure and explores childhood activity as prevention for osteoporosis in later life

Design Mixers to Minimize Effects of Erosion and Corrosion Erosion

A thorough review of the major parameters that affect solid-liquid slurry wear on impellers and techniques for minimizing wear is presented. These major parameters include (i) chemical environment, (ii) hardness of solids, (iii) density of solids, (iv) percent solids, (v) shape of solids, (vi) fluid regime (turbulent, transitional, or laminar), (vii) hardness of the mixer\u27s wetted parts, (viii) hydraulic efficiency of the impeller (kinetic energy dissipation rates near the impeller blades), (ix) impact velocity, and (x) impact frequency. Techniques for minimizing the wear on impellers cover the choice of impeller, size and speed of the impeller, alloy selection, and surface coating or coverings. An example is provided as well as an assessment of the approximate life improvement

Free space in the academy

“Academic freedom” does not mean the same thing to everyone. There are, to be sure, a few who argue against it. Sandra Korn, in the Harvard Crimson last year, argued that we should abandon academic freedom in favor of academic justice. She argues that we have reached a consensus on issues such as racism, classism and sexism, and so to promote racist or classist or sexist views under the guise of “academic freedom” is to ignore a higher standard and more importantly to ignore the fact that academic freedom is always couched in political realities, and is never the dispassionate exercise of reason and the pursuit of knowledge. It always serves an agenda, and so if that is the case, it should serve the agenda of justice, particularly justice for disadvantaged and marginalized people. Her online article, when I last looked, had almost 1300 comments, and had inspired commentary from a number of other publications. You can imagine the range of these comments and reactions: everything from “this is long overdue” to the newest favorite insult circulating the internet, “she’s just another Social Justice Warrior (SJW).

Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina.

Previous studies have demonstrated that ribbon synapses in the retina do not contain the t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor) syntaxin 1A that is found in conventional synapses of the nervous system. In contrast, ribbon synapses of the retina contain the related isoform syntaxin 3. In addition to its localization in ribbon synapses, syntaxin 3 is also found in nonneuronal cells, where it has been implicated in the trafficking of transport vesicles to the apical plasma membrane of polarized cells. The syntaxin 3 gene codes for four different splice forms, syntaxins 3A, 3B, 3C, and 3D. We demonstrate here by using analysis of EST databases, RT-PCR, in situ hybridization, and Northern blot analysis that cells in the mouse retina express only syntaxin 3B. In contrast, nonneuronal tissues, such as kidney, express only syntaxin 3A. The two major syntaxin isoforms (3A and 3B) have an identical N-terminal domain but differ in the C-terminal half of the SNARE domain and the C-terminal transmembrane domain. These two domains are thought to be directly involved in synaptic vesicle fusion. The interaction of syntaxin 1A and syntaxin 3B with other synaptic proteins was examined. We found that both proteins bind Munc18/N-sec1 with similar affinity. In contrast, syntaxin 3B had a much lower binding affinity for the t-SNARE SNAP25 compared with syntaxin 1A. By using an in vitro fusion assay, we could demonstrate that vesicles containing syntaxin 3B and SNAP25 could fuse with vesicles containing synaptobrevin2/VAMP2, demonstrating that syntaxin 3B can function as a t-SNARE