Complete One-Loop MSSM Predictions for B --> lepton lepton' at the Tevatron and LHC

During the last few years the Tevatron has dramatically improved the bounds on rare B-meson decays into two leptons. In the case of B_s --> mu+ mu-, the current bound is only ten times greater than the Standard Model expectation. Sensitivity to this decay is one of the benchmark goals for LHCb performance and physics. The Higgs penguin dominates this rate in the region of large tan(beta) of the MSSM. This is not necessarily the case in the region of low tan(beta), since box and Z-penguin diagrams may contribute at a comparable rate. In this article, we compute the complete one-loop MSSM contribution to B --> l+l'- for l,l' = e, mu. We study the predictions for general values of tan(beta) with arbitrary flavour mixing parameters. We discuss the possibility of both enhancing and suppressing the branching ratios relative to their Standard Model expectations. In particular, we find that there are "cancellation regions" in parameter space where the branching ratio is suppressed well below the Standard Model expectation, making it effectively invisible to the LHC.Comment: 30 pages, 4 figures; v.3: corrected factors of (2 pi) in (2.11), (3.1), (A.11), (A.13-14

A homology model of restriction endonuclease SfiI in complex with DNA

BACKGROUND: Restriction enzymes (REases) are commercial reagents commonly used in recombinant DNA technologies. They are attractive models for studying protein-DNA interactions and valuable targets for protein engineering. They are, however, extremely divergent: the amino acid sequence of a typical REase usually shows no detectable similarities to any other proteins, with rare exceptions of other REases that recognize identical or very similar sequences. From structural analyses and bioinformatics studies it has been learned that some REases belong to at least four unrelated and structurally distinct superfamilies of nucleases, PD-DxK, PLD, HNH, and GIY-YIG. Hence, they are extremely hard targets for structure prediction and homology-based inference of sequence-function relationships and the great majority of REases remain structurally and evolutionarily unclassified. RESULTS: SfiI is a REase which recognizes the interrupted palindromic sequence 5'GGCCNNNN^NGGCC3' and generates 3 nt long 3' overhangs upon cleavage. SfiI is an archetypal Type IIF enzyme, which functions as a tetramer and cleaves two copies of the recognition site in a concerted manner. Its sequence shows no similarity to other proteins and nothing is known about the localization of its active site or residues important for oligomerization. Using the threading approach for protein fold-recognition, we identified a remote relationship between SfiI and BglI, a dimeric Type IIP restriction enzyme from the PD-DxK superfamily of nucleases, which recognizes the 5'GCCNNNN^NGGC3' sequence and whose structure in complex with the substrate DNA is available. We constructed a homology model of SfiI in complex with its target sequence and used it to predict residues important for dimerization, tetramerization, DNA binding and catalysis. CONCLUSIONS: The bioinformatics analysis suggest that SfiI, a Type IIF enzyme, is more closely related to BglI, an "orthodox" Type IIP restriction enzyme, than to any other REase, including other Type IIF REases with known structures, such as NgoMIV. NgoMIV and BglI belong to two different, very remotely related branches of the PD-DxK superfamily: the α-class (EcoRI-like), and the β-class (EcoRV-like), respectively. Thus, our analysis provides evidence that the ability to tetramerize and cut the two DNA sequences in a concerted manner was developed independently at least two times in the evolution of the PD-DxK superfamily of REases. The model of SfiI will also serve as a convenient platform for further experimental analyses

Superenergy and Supermomentum of Goedel Universes

We review the canonical superenergy tensor and the canonical angular supermomentum tensors in general relativity and calculate them for space-time homogeneous G\"odel universes to show that both of these tensors do not, in general, vanish. We consider both an original dust-filled pressureless acausal G\"odel model of 1949 and a scalar-field-filled causal G\"odel model of Rebou\c cas and Tiomno. For the acausal model, the non-vanishing components of superenergy of matter are different from those of gravitation. The angular supermomentum tensors of matter and gravitation do not vanish either which simply reflects the fact that G\"odel universe rotates. However, the axial (totally antisymmetric) and vectorial parts of supermomentum tensors vanish. It is interesting that superenergetic quantities are {\it sensitive} to causality in a way that superenergy density $_g S_{00}$ of gravitation in the acausal model is {\it positive}, while superenergy density $_g S_{00}$ in the causal model is {\it negative}. That means superenergetic quantities might serve as criterion of causality in cosmology and prove useful.Comment: an amended version, REVTEX, 26 pages, no figures, to appear in Classical and Quantum Gravit

Thermodynamic forces, flows, and Onsager coefficients in complex networks

We present Onsager formalism applied to random networks with arbitrary degree distribution. Using the well-known methods of non-equilibrium thermodynamics we identify thermodynamic forces and their conjugated flows induced in networks as a result of single node degree perturbation. The forces and the flows can be understood as a response of the system to events, such as random removal of nodes or intentional attacks on them. Finally, we show that cross effects (such as thermodiffusion, or thermoelectric phenomena), in which one force may not only give rise to its own corresponding flow, but to many other flows, can be observed also in complex networks.Comment: 4 pages, 2 figure

Crossover of interface growth dynamics during corrosion and passivation

We study a model of corrosion and passivation of a metalic surface in contact with a solution using scaling arguments and simulation. The passive layer is porous so that the metal surface is in contact with the solution. The volume excess of the products may suppress the access of the solution to the metal surface, but it is then restored by a diffusion mechanism. A metalic site in contact with the solution or with the porous layer can be passivated with rate p and volume excess diffuses with rate D. At small times, the corrosion front linearly grows in time, but the growth velocity shows a t^{-1/2} decrease after a crossover time of order t_c ~ D/p^2, where the average front height is of order h_c ~ D/p. A universal scaling relation between h/h_c and t/t_c is proposed and confirmed by simulation for 0.00005 <= p <= 0.5 in square lattices. The roughness of the corrosion front shows a crossover from Kardar-Parisi-Zhang scaling to Laplacian growth (diffusion-limited erosion - DLE) at t_c. The amplitudes of roughness scaling are obtained by the same kind of arguments as previously applied to other competitive growth models. The simulation results confirm their validity. Since the proposed model captures the essential ingredients of different corrosion processes, we also expect these universal features to appear in real systems.Comment: 17 pages, including 7 figures; submitted articl

Mechanical and Tribological Properties of Carbon-Based Graded Coatings

The paper presents research on coatings with advanced architecture, composed of a Cr/Cr2N ceramic/metal multilayer and graded carbon layers with varying properties from Cr/a-C:H to a-C:N. The microstructure of the coatings was analysed using transmission electron microscopy and Energy Dispersive Spectroscopy, the mechanical properties were tested by nanoindentation, spherical indentation, and scratch testing, and tribological tests were also conducted. The proper selection of subsequent layers in graded coatings allowed high hardness and fracture resistance to be obtained as well as good adhesion to multilayers. Moreover, these coatings have higher wear resistance than single coatings and a friction coefficient equal to 0.25

Ethical aspect of quality of life of palliative care patients

In the paper, we attempt a semantic analysis of patient quality of life, which plays an important role in evaluating the patient’s condition and health. The issue seems to be the most important in palliative-hospice care, where doctors work with seriously or terminally ill patients. One of the aims of this branch of medicine is to improve quality of life. This may be achieved, among others, by recognizing the current problems the patient is facing pertaining to family and social relations, beliefs, views or religion. Moreover, by monitoring the behavior of patients and symptoms of their illnesses, the best therapy methods may be selected. Patient quality of life assessment may also enable comparing health care units of the same specialization and be used for the selection of the best standards of care. When discussing the broader meaning of "quality of life", we caution against equating quality of life with the value of life. The main arguments are as follows: subjective character of evaluation of quality of life and, in the future, the possibility of postulates for shortening life of poor quality of life patients when funds for their treatment are insufficient. When accepting quality of life as equal to the value of life, it may result in eliminating unprotected and helpless patients and allowing only the strong to live. Later, this may result in the discrimination of seriously and terminally ill people, even those who do not wish to shorten their lives despite experiencing burdensome symptoms and being aware of the incurable nature of their illness