Secondary pulmonary alveolar proteinosis treated by lung transplant: A case report.

Pulmonary alveolar proteinosis (PAP) is a pulmonary disease characterized by disruption of surfactant homeostasis resulting in its accumulation in the alveoli. PAP is classically classified into three categories (Table 1): 1/primary (or autoimmune) with antibodies targeting the GM-CSF pathway, 2/secondary to another disease, typically a hematologic malignancy, and 3/genetic. A 30 year-old woman received an allogenic hematopoietic stem cell transplantation (HSCT) after treatment for acute myeloid leukemia (AML). Within the first 6 months post HSCT, she developed an ocular, oral, digestive and hepatic graft-versus-host disease associated with a mixed ventilatory defect with a very severe obstructive syndrome and a severe CO diffusion impairment. High resolution computed tomography showed a classical "crazy paving" pattern. Aspect and differential cell count of BAL were normal. All microbiological samples remained culture negative. Histo-pathological analysis of transbronchial biopsies was unremarkable. Because of the severity of the respiratory insufficiency, open-lung biopsy (OBL) could not be performed. Despite multiple immunosuppressive therapies, lung function deteriorated rapidly; the patient also developed an excavated fungal lesion unresponsive to treatment. She underwent a bilateral lung transplant 48 months after HSCT. Histo-pathological analysis of explanted lungs showed obliterative bronchiolitis (OB), diffuse PAP and invasive cavitary pulmonary aspergillosis. This case illustrates the simultaneous occurrence of OB, PAP and a fungal infection in a 30-year old female patient who underwent HSCT for acute myeloid leukemia (AML). To our knowledge this is the only documented case of PAP associated with OB treated by lung transplantation

Search for sharp lines in e+-e- coincidences from positrons on Th

Two mini-orange spectrometers were used to view e+-e- pairs from a positron source and a Th scatterer from opposite directions, 180° apart. No statistically significant evidence for peaks previously reported was found in the coincidence spectra

Inference of Well-Typings for Logic Programs with Application to Termination Analysis

This paper develops a method to infer a polymorphic well-typing for a logic program. One of the main motivations is to contribute to a better automation of termination analysis in logic programs, by deriving types from which norms can automatically be constructed. Previous work on type-based termination analysis used either types declared by the user, or automatically generated monomorphic types describing the success set of predicates. Declared types are typically more precise and result in stronger termination conditions than those obtained with inferred types. Our type inference procedure involves solving set constraints generated from the program and derives a well-typing in contrast to a success-set approximation. Experiments show that our automatically inferred well-typings are close to the declared types and thus result in termination conditions that are as good as those obtained with declared types for all our experiments to date. We describe the method, its implementation and experiments with termination analysis based on the inferred types

The influence of νh11/2 occupancy on the magnetic moments of collective 21+ states in A∼100 fission fragments

AbstractThe magnetic moments of Iπ=21+ states in even–even A∼100 fission fragments have been measured using the Gammasphere array, using the technique of time-integral perturbed angular correlations. The data are interpreted within the context of the interacting boson model (IBA2) leading to the suggestion of a strong νh11/2 component in the deformed 21+ states of this region

Production of radioactive ion beams using the in-flight technique

Reactions with a heavy projectile incident on a light target can be used for the efficient in-flight production of secondary radioactive beams. An overview of this technique is given using data on 17F beams produced via the p(17O, 17F)n and d(16O, 17F)n reactions. With primary 16,17O beam currents of 100 pnA, intensities of up to 2×106 17F/s on target were achieved. Using this beam, the p(17F, α) 14O reaction was measured

The 136Xe + 198Pt reaction: a detailed re-examination

We extend previous measurements of the transfer product yields in the reaction of Ec.m.=450MeV136Xe with 198Pt by measurements of the product yields using Gammasphere. By recording events occurring in beam bursts and in between beam bursts, we are able to extend the number of measured product yields from 78 to 171 nuclides. Our new data span a much wider range of Z and A than observed in previous work and when compared to theoretical predictions, these new measurements provide a more stringent and thorough test of models of multi-nucleon transfer (MNT) reactions

α decay of 97249Bk and levels in 95245Am

α decay of 249Bk has been investigated by measuring its α and γ-ray spectra, both in singles and in coincidence modes. The α spectrum of a freshly purified 249Bk sample was measured with a high-resolution, double-focusing magnetic spectrometer. γ singles, γ-γ coincidence, and γ-α coincidence spectra were also recorded. The absolute intensity of the 327.45-keV γ ray has been determined to be (1.44±0.08)×10-5% per 249Bk decay. Assignments of previously known single-particle states were confirmed. A new rotational band was identified in the α singles spectrum and Am K x rays have been observed in its decay. This single-particle state, with an energy of 154 keV, has been assigned to the 3/2-[521] Nilsson state. This is the lowest excitation energy for this orbital in any Am nucleus. More precise energies and intensities of the 249Bk α groups and γ-ray transitions are provided

Determinacy analysis for logic programs using mode and type information

We propose an analysis for detecting procedures and goals that are deterministic (i.e. that produce at most one solution), or predicates whose clause tests are mutually exclusive (which implies that at most one of their clauses will succeed) even if they are not deterministic (because they cali other predicates that can produce more than one solution). Applications of such determinacy information include detecting programming errors, performing certain high-level program transformations for improving search efñciency, optimizing low level code generation and parallel execution, and estimating tighter upper bounds on the computational costs of goals and data sizes, which can be used for program debugging, resource consumption and granularity control, etc. We have implemented the analysis and integrated it in the CiaoPP system, which also infers automatically the mode and type information that our analysis takes as input. Experiments performed on this implementation show that the analysis is fairly accurate and efncient

Level structure of 30S: Implications for the astrophysical 29P(p,γ)30S reaction rate in ONe novae and x-ray bursts

A γ-ray spectroscopy study of 30S is presented. Excitation energies have been determined with improved precision over previous studies and firm spin-parity assignments have been made for key 29P+p resonant states. An evaluation of the 29P(p,γ)30S reaction for T=0.08-2.5 GK shows that the 3+ and 2+ resonant states located at Er=289(3) and 410(3) keV, respectively, dominate the 29P(p,γ)30S reaction rate in ONe novae, while the 410-keV resonance is expected to govern the rate in x-ray burster environments. These new, precise resonance energy measurements and firm spin-parity assignments have significantly reduced uncertainties in the 29P(p,γ)30S reaction in ONe novae and x-ray bursts. In particular, the reaction rate is now specified precisely enough for calculations of isotopic abundances in ONe novae ejecta

Precise absolute γ -ray and β- -decay branching intensities in the decay of Cu 2967

Absolute γ-ray emission probabilities in the β- decay of Cu67 were measured by means of γ-ray and β - decay singles and β - γ coincidences. The new results, together with the known decay scheme of Cu67, were used to determine absolute β - decay branching intensities. The present data differ significantly from previously published values. In addition, the half-life of the Iπ=12- isomer in Zn67 was measured as T1/2=9.37(4) μs, in a good agreement with earlier measurements. From the analysis of the Fermi-Kurie plots, Qβ-(g.s.)=560.3(10) keV was deduced, which differs from the previously measured value of 577(8) keV but is in good agreement with Qβ-(g.s.)=561.3(15) keV recommended in the latest Atomic Mass Evaluation