3,950 research outputs found
Excellent outcomes can be achieved in children on HAART under routine program conditions in Cambodia. Experience from two hospitals in Siem Reap and Takeo, Cambodia
Effectiveness of highly active antiretroviral therapy in HIV-positive children: evaluation at 12 months in a routine program in Cambodia.
OBJECTIVE: Increasing access to highly active antiretroviral therapy to reach all those in need in developing countries (scale up) is slowly expanding to HIV-positive children, but documented experience remains limited. We aimed to describe the clinical, immunologic, and virologic outcomes of pediatric patients with >12 months of highly active antiretroviral therapy in 2 routine programs in Cambodia. METHODS: Between June 2003 and March 2005, 212 children who were younger than 13 years started highly active antiretroviral therapy. Most patients started a standard first-line regimen of lamivudine, stavudine, and nevirapine, using split adult fixed-dosage combinations. CD4 percentage and body weight were monitored routinely. A cross-sectional virologic analysis was conducted in January 2006; genotype resistance testing was performed for patients with a detectable viral load. RESULTS: Mean age of the subjects was 6 years. Median CD4 percentage at baseline was 6. Survival was 92% at 12 months and 91% at 24 months; 13 patients died, and 4 were lost to follow-up. A total of 81% of all patients had an undetectable viral load. Among the patients with a detectable viral load, most mutations were associated with resistance to lamivudine and non-nucleoside reverse-transcriptase inhibitor drugs. Five patients had developed extensive antiretroviral resistance. Being an orphan was found to be a predictor of virologic failure. CONCLUSIONS: This study provides additional evidence of the effectiveness of integrating HIV/AIDS care with highly active antiretroviral therapy for children in a routine setting, with good virologic suppression and immunologic recovery achieved by using split adult fixed-dosage combinations. Viral load monitoring and HIV genotyping are valuable tools for the clinical follow-up of the patients. Orphans should receive careful follow-up and extra support
A Composite Chiral Pair of Rotational Bands in the odd-A Nucleus 135Nd
High-spin states in 135Nd were populated with the 110Pd(30Si,5n)135Nd
reaction at a 30Si bombarding energy of 133 MeV. Two Delta(I)=1 bands with
close excitation energies and the same parity were observed. These bands are
directly linked by Delta(I)=1 and Delta(I)=2 transitions. The chiral nature of
these two bands is confirmed by comparison with three-dimensional tilted axis
cranking calculations. This is the first observation of a three-quasiparticle
chiral structure and established the primarily geometric nature of this
phenomenon.Comment: 10 pages, 5 figures (1 in color), 1 table, submitted to Physics
Review Letters, written in REVTEX4 forma
Lifetime measurements of Triaxial Strongly Deformed bands in Tm
With the Doppler Shift Attenuation Method, quadrupole transition moments,
, were determined for the two recently proposed Triaxial Strongly Deformed
(TSD) bands in Tm. The measured moments indicate that the
deformation of these bands is larger than that of the yrast, signature
partners. However, the measured values are smaller than those predicted by
theory. This observation appears to be valid for TSD bands in several nuclei of
the regionComment: 8 pages, 5 figures. Submitted to Physical Review
Evolution and biogeography of the Pavetteae tribe
With over 700 species, the Pavetteae are one o f the largest tribes in the subfamily Dialypetalanthoideae (formerly: Ixoroideae). Pavetteae representatives are characterized by a high morphological variation, especially regarding the reproductive characters (e.g., number of seeds per fruit, seed type and placentation). Representatives of the tribe occur throughout the Paleotropics in humid and dry vegetation types. In the Asian-Pacific región ca 300 species are currently described whereas on continental Africa and Madagascar (and Western Indian Ocean Islands) ca 350 and ca 80 species are present, respectively. Recently many new genera have been recognized among the Malagasy Pavetteae species (e.g. Tulearia). In addition, it is clear that within the paleotropical genus Tarenna there will be a split into different genera. Not only is the taxonomic history of the tribe rather complicated, also the biogeographical history and evolutionary patterns of the tribe remain understudied to date. Molecular phylogenetics combined with age inference methods, diversificaron analyses and ancestral area reconstruction clearly indicate that current diversity of the Pavetteae is the result of several dispersal events within the Paleotropical region. Moreover, several shifts in ecological preference have likely driven the evolutionary history within the Pavetteae
Direct current control of three magnon scattering processes in spin-valve nanocontacts
We have investigated the generation of spin waves in the free layer of an
extended spin-valve structure with a nano-scaled point contact driven by both
microwave and direct electric current using Brillouin light scattering
microscopy. Simultaneously with the directly excited spin waves, strong
nonlinear effects are observed, namely the generation of eigenmodes with
integer multiple frequencies (2 \emph{f}, 3 \emph{f}, 4 \emph{f}) and modes
with non-integer factors (0.5 \emph{f}, 1.5 \emph{f}) with respect to the
excitation frequency \emph{f}. The origin of these nonlinear modes is traced
back to three magnon scattering processes. The direct current influence on the
generation of the fundamental mode at frequency \emph{f} can be related to the
spin-transfer torque, while the efficiency of three-magnon-scattering processes
is controlled by the Oersted field as an additional effect of the direct
current
Fusion-Fission of 16O+197Au at Sub-Barrier Energies
The recent discovery of heavy-ion fusion hindrance at far sub-barrier
energies has focused much attention on both experimental and theoretical
studies of this phenomenon. Most of the experimental evidence comes from
medium-heavy systems such as Ni+Ni to Zr+Zr, for which the compound system
decays primarily by charged-particle evaporation. In order to study heavier
systems, it is, however, necessary to measure also the fraction of the decay
that goes into fission fragments. In the present work we have, therefore,
measured the fission cross section of 16O+197Au down to unprecedented far
sub-barrier energies using a large position sensitive PPAC placed at backward
angles. The preliminary cross sections will be discussed and compared to
earlier studies at near-barrier energies. No conclusive evidence for
sub-barrier hindrance was found, probably because the measurements were not
extended to sufficiently low energies.Comment: Fusion06 - Intl. Conf. on Reaction Mechanisms and Nuclear Structure
at the Coulomb Barrier, San Servolo, Venezia, Italy, March 19-223, 2006 5
pages, 4 figure
Single and vertically coupled type II quantum dots in a perpendicular magnetic field: exciton groundstate properties
The properties of an exciton in a type II quantum dot are studied under the
influence of a perpendicular applied magnetic field. The dot is modelled by a
quantum disk with radius , thickness and the electron is confined in the
disk, whereas the hole is located in the barrier. The exciton energy and
wavefunctions are calculated using a Hartree-Fock mesh method. We distinguish
two different regimes, namely (the hole is located at the radial
boundary of the disk) and (the hole is located above and below the
disk), for which angular momentum transitions are predicted with
increasing magnetic field. We also considered a system of two vertically
coupled dots where now an extra parameter is introduced, namely the interdot
distance . For each and for a sufficient large magnetic field,
the ground state becomes spontaneous symmetry broken in which the electron and
the hole move towards one of the dots. This transition is induced by the
Coulomb interaction and leads to a magnetic field induced dipole moment. No
such symmetry broken ground states are found for a single dot (and for three
vertically coupled symmetric quantum disks). For a system of two vertically
coupled truncated cones, which is asymmetric from the start, we still find
angular momentum transitions. For a symmetric system of three vertically
coupled quantum disks, the system resembles for small the pillar-like
regime of a single dot, where the hole tends to stay at the radial boundary,
which induces angular momentum transitions with increasing magnetic field. For
larger the hole can sit between the disks and the state
remains the groundstate for the whole -region.Comment: 11 pages, 16 figure
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