1,207 research outputs found
Rent increase strategies and distributive justice: the socio-spatial effects of rent control policy in Amsterdam
Naar een metropolitaan bewustzijn
Sinds de introductie van de Metropoolregio Amsterdam staan de begrippen metropool en metropoolvorming opnieuw volop in de aandacht. De netwerkstad Noordvleugel moet uitgroeien tot volwaardige Europese metropool, aldus het ontwikkelingsbeeld Metropoolregio Amsterdam 2040. Maar wat is een metropool? En hoe maakbaar is deze? Metropolen zijn vaak lastig af te bakenen en zeer dynamisch, wat planningsinnovaties op dit niveau lastig maakt. Ervaringen in verschillende andere landen laten dan ook zien dat het ontstaan van een metropolitaan bewustzijn niet vanzelfsprekend i
Prospects for high-resolution microwave spectroscopy of methanol in a Stark-deflected molecular beam
Recently, the extremely sensitive torsion-rotation transitions in methanol
have been used to set a tight constraint on a possible variation of the
proton-to-electron mass ratio over cosmological time scales. In order to
improve this constraint, laboratory data of increased accuracy will be
required. Here, we explore the possibility for performing high-resolution
spectroscopy on methanol in a Stark-deflected molecular beam. We have
calculated the Stark shift of the lower rotational levels in the ground
torsion-vibrational state of CH3OH and CD3OH molecules, and have used this to
simulate trajectories through a typical molecular beam resonance setup.
Furthermore, we have determined the efficiency of non-resonant multi-photon
ionization of methanol molecules using a femtosecond laser pulse. The described
setup is in principle suited to measure microwave transitions in CH3OH at an
accuracy below 10^{-8}
Network theory approach for data evaluation in the dynamic force spectroscopy of biomolecular interactions
Investigations of molecular bonds between single molecules and molecular
complexes by the dynamic force spectroscopy are subject to large fluctuations
at nanoscale and possible other aspecific binding, which mask the experimental
output. Big efforts are devoted to develop methods for effective selection of
the relevant experimental data, before taking the quantitative analysis of bond
parameters. Here we present a methodology which is based on the application of
graph theory. The force-distance curves corresponding to repeated pulling
events are mapped onto their correlation network (mathematical graph). On these
graphs the groups of similar curves appear as topological modules, which are
identified using the spectral analysis of graphs. We demonstrate the approach
by analyzing a large ensemble of the force-distance curves measured on:
ssDNA-ssDNA, peptide-RNA (system from HIV1), and peptide-Au surface. Within our
data sets the methodology systematically separates subgroups of curves which
are related to different intermolecular interactions and to spatial
arrangements in which the molecules are brought together and/or pulling speeds.
This demonstrates the sensitivity of the method to the spatial degrees of
freedom, suggesting potential applications in the case of large molecular
complexes and situations with multiple binding sites
Test characteristics of Raman spectroscopy integrated with polarized light microscopy for the diagnosis of acute gouty arthritis
Diagnostic Accuracy of Raman Spectroscopy Integrated With Polarized Light Microscopy for Calcium Pyrophosphate–Associated Arthritis
Objective: We studied the performance of integrated Raman polarized light microscopy (iRPolM) for the identification of calcium pyrophosphate (CPP)–associated arthritis (CPPD). Methods: This is a diagnostic accuracy study including 400 consecutive synovial fluid samples from a single hospital in the Netherlands. Accuracy measures were calculated against polarized light microscopy (PLM) and the 2023 American College of Rheumatology (ACR)/EULAR criteria set for CPPD. Results: The interrater reliability between iRPolM and the 2023 ACR/EULAR criteria set for CPPD was strong (κ = 0.88). The diagnostic performance of iRPolM compared to the 2023 ACR/EULAR criteria set was sensitivity 86.0% (95% confidence interval [CI] 73.3–94.2), specificity 99.1% (95% CI 97.5–99.8), positive likelihood ratio 100.33 (95% CI 32.3–311.3), negative likelihood ratio 0.14 (95% CI 0.07–0.28), positive predictive value 93.5% (95% CI 82.2–97.8), negative predictive value 98.0% (95% CI 82.2–97.8), and accuracy 97.5% (95% CI 95.5–98.8). We allowed rheumatologists to rate the certainty of their microscopic identification of CPP and found a large correspondence between iRPolM and a certain identification (κ = 0.87), whereas only 10% of the uncertain CPP identifications could be confirmed with iRPolM. We identified several novel particle types in synovial fluid analysis, including calcium carbonate crystals, deposited carotenoids, microplastics, and three types of Maltese cross birefringent objects. Conclusion: iRPolM can easily identify CPP crystals with a strong diagnostic performance. PLM alone is not specific enough to reliably resolve complicated cases, and the implementation of Raman spectroscopy in rheumatology practice can be of benefit to patients with suspected CPPD.</p
Irreducible Representations of Diperiodic Groups
The irreducible representations of all of the 80 diperiodic groups, being the
symmetries of the systems translationally periodical in two directions, are
calculated. To this end, each of these groups is factorized as the product of a
generalized translational group and an axial point group. The results are
presented in the form of the tables, containing the matrices of the irreducible
representations of the generators of the groups. General properties and some
physical applications (degeneracy and topology of the energy bands, selection
rules, etc.) are discussed.Comment: 30 pages, 5 figures, 28 tables, 18 refs, LaTex2.0
Raman hyperspectral imaging detects novel and combinations of crystals in synovial fluids of patients with a swollen joint
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