Divergence was estimated by using the human (GenBank: ) and chimpanzee (this study, Genbank: ) reference sequences alone or by incorporating the diversity data obtained from re-sequencing for one or both species into the calculations

The re-sequencing data for human (n = 95) originated from the published study[] and for chimpanzee (n = 11) from the unpublished dataset of the authors.<p><b>Copyright information:</b></p><p>Taken from "High divergence in primate-specific duplicated regions: Human and chimpanzee genes"</p><p>http://www.biomedcentral.com/1471-2148/8/195</p><p>BMC Evolutionary Biology 2008;8():195-195.</p><p>Published online 7 Jul 2008</p><p>PMCID:PMC2478647.</p><p></p

High divergence in primate-specific duplicated regions: Human and chimpanzee genes-0

Quences from []. Phylogenetic analysis of intergenic regions was conducted with segments without (B-D) and with (E-G) covering pseudogenes. The homologous segments used for each respective phylogenetic analysis are indicated with a circle on a consensus structure of the intergenic regions in cluster (boxed; from Figure 1B). The nomenclature of the intergenic regions is as on Figure 1B. Bootstrap support values are shown at the nodes (1000 bootstrap replications). Abbreviations: hu – human, ch – chimpanzee, gor – gorilla, orang – orangutan.<p><b>Copyright information:</b></p><p>Taken from "High divergence in primate-specific duplicated regions: Human and chimpanzee genes"</p><p>http://www.biomedcentral.com/1471-2148/8/195</p><p>BMC Evolutionary Biology 2008;8():195-195.</p><p>Published online 7 Jul 2008</p><p>PMCID:PMC2478647.</p><p></p

High divergence in primate-specific duplicated regions: Human and chimpanzee genes-2

and genes (in total 6,878 bp; GC-nucleotide content 64%; 161 substitutions). (B) Nucleotide substitutions in the whole orthologous region of the genome cluster (in total 36,211 bp, GC-nucleotide content 57%, 835 substitutions). Percents for all substitution types are shown with summarized information for transversions and transitions.<p><b>Copyright information:</b></p><p>Taken from "High divergence in primate-specific duplicated regions: Human and chimpanzee genes"</p><p>http://www.biomedcentral.com/1471-2148/8/195</p><p>BMC Evolutionary Biology 2008;8():195-195.</p><p>Published online 7 Jul 2008</p><p>PMCID:PMC2478647.</p><p></p

High divergence in primate-specific duplicated regions: Human and chimpanzee genes-1

(Ch)/7,973 bp (Hu) from gene to the end of and 29,136 bp (Ch)/28,568 bp (Hu) from to gene. The species-specific large duplications (human 12,700 bp, chimp 6,725 bp) have been excluded from the comparison. The percents of nucleotide substitutions and indels are calculated per 500 bp non-overlapping windows. Grey arrows indicate the locations of coding genes drawn to an approximate scale. – denote intergenic regions from Figure 1B. Intergenic repeat fraction includes , satellites, simple repeats and low complexity DNA sequences within each intergenic region.<p><b>Copyright information:</b></p><p>Taken from "High divergence in primate-specific duplicated regions: Human and chimpanzee genes"</p><p>http://www.biomedcentral.com/1471-2148/8/195</p><p>BMC Evolutionary Biology 2008;8():195-195.</p><p>Published online 7 Jul 2008</p><p>PMCID:PMC2478647.</p><p></p

A Description of the FINRISK 1992 and 1997 Cohorts

<p>Compared to FINRISK-92, the FINRISK-97 cohort includes an additional sample of individuals aged 65–74 y. Numbers for this additional sample are described at the right-hand side for each endpoint. Persons examined refers to cohort individuals for whom information on smoking, blood pressure, cholesterol, and DNA, as well as consent for the use of DNA to study CHD and stroke, were available. Subcohorts are stratified random samples of the original cohorts including also cases. Mortality cases show total mortality, including also those who died from CHD or stroke. Thus, numbers in the boxes of subcohorts and outcome events are not mutually exclusive (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020069#pgen-0020069-t001" target="_blank">Table 1</a>). F, females; M, males.</p

Haplotype Block Structure of the <i>PRKCA</i> Gene in Finnish and Canadian Populations

<p>(A) shows the block structures of the <i>PRKCA</i> gene (between SNPs rs3764402 and rs4791037) in 211 Finnish MS families; (B), in the 554 Canadian MS families. The haplotype blocks were created using the solid line of LD of the Haploview program, version 3.2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b027" target="_blank">27</a>]. The SNPs providing strongest evidence for association to MS in <i>PRKCA</i> in Finns and Canadians (rs887797, rs2361491 and rs2078153, rs1860984, respectively) are marked with black arrows, SNPs used in Haploview version 3.2 [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b027" target="_blank">27</a>] haplotype analysis in 211 Finnish families are indicated with boxes, and those used in the two SNP genotype combinations are indicated with a white arrowhead with the letter H and the rs-numbers given above.</p

Schematic Representation of the MS Locus on Chromosome 17q24

<p>Positions of the SNPs used in stages I, II, and III are shown with arrowheads. Grey arrowheads indicate SNPs showing evidence for association: stage I, <i>p</i> < 0.05; stage II, <i>p</i> < 0.01. SNP rs887797 showing evidence for association in the two independent Finnish study sets (Study sets I and II) is shown with a black arrow. The horizontal bar indicates the position of the critical MS region identified by haplotype analysis in our previous study [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020042#pgen-0020042-b021" target="_blank">21</a>]. The positions of the genes mapping to the locus are shown as boxes below.</p