Injection use in two districts of Pakistan: implications for disease prevention

Objective. To estimate the annual number of injections per person in Sindh province of Pakistan and to describe their distribution with regard to prescribers, settings, and safety. Design. A population-based cross-sectional study in July-September 2001. Setting. Lyari, an urban town in Karachi district; and Digri, a rural subdistrict in Mirpur Khas district. Study participants. We selected a population-based cluster sample of 1150 individuals aged ≥3 months. We interviewed one person per household for the number of encounters they had with health care providers, number and types of injections received, safety circumstances, and cost of injections during the past 3 months. Main outcome measure. The number of injections per person per year. Results. After adjusting for age and sex, 68% of participants had received at least one injection in the previous 3 months (13.6 injections/person/year). The majority of the respondents received injections at the clinics of qualified general practitioners (n = 571, 67%) by dispensers (644, 76%). Most of the injections (n = 3446, 96%) were for curative purposes. A freshly opened syringe was used for only 454 (53%) of the injections. The average fee for receiving an injection was Rs. 51 (US$0.8). Conclusion. Injections are overused in Pakistan's Sindh province and the ratios of injection per capita that we found are among the highest ever reported. Interventions are needed to substantially reduce injection prescription among private health care providers who prescribe most of the injections received by the populatio

Association between Injections and HIV Incidence

Editors of medical journals accept that published research should be open to comment and correction in published correspondence ([1]; Box 1).“Post-publication peer review” enables comments on, clarifications of, and corrections to published research. All journals should have a correspondence page for this purpose. I previously criticised the effective “statute of limitations” in several leading general medical journals “whereby authors of papers are immune to disclosure of methodological weaknesses once some arbitrar

Determinants of low birth weight in urban Pakistan

Objective: To identify determinants of low birth weight (LBW) in Karachi, Pakistan, including environmental exposures and nutritional status of the mother during pregnancy. Design: Cross-sectional study. Participants: Five hundred and forty mother-infant pairs. We interviewed mothers about obstetric history, diet and exposure to Pb. We measured birth weight and blood lead level (BLL). We performed multiple log binomial regression analysis to identify factors related to LBW.Results: Of 540 infants, 100 (18.5%) weighed 208.7 mg/d), infants of mothers with MUAC less than or equal to the median and dietary vitamin C intake \u3e 208-7 mg/d (adjPR = 10.80, 95 % CI 1.46, 79.76), mothers with MUAC above the median and vitamin C intak

Hepatitis C cross-genotype immunity and implications for vaccine development.

While about a quarter of individuals clear their primary hepatitis C (HCV) infections spontaneously, clearance (spontaneous or treatment-induced) does not confer sterilizing immunity against a future infection. Since successful treatment does not prevent future infections either, an effective vaccine is highly desirable in preventing HCV (re)infection. However, development of an effective vaccine has been complicated by the diversity of HCV genotypes, and complexities in HCV immunological responses. Smaller studies on humans and chimpanzees reported seemingly opposing results regarding cross-neutralizing antibodies. We report a lack of cross-genotype immunity in the largest cohort of people to date. In the adjusted Cox proportional hazards model, reinfection with a heterologous HCV genotype (adjusted Hazard Ratio [aHR]: 0.45, 95% CI: 0.25-0.84) was associated with a 55% lower likelihood of re-clearance. Among those who cleared their first infection spontaneously, the likelihood of re-clearance was 49% lower (aHR: 0.51, 95% CI: 0.27-0.94) when reinfected with a heterologous HCV genotype. These findings indicate that immunity against a particular HCV genotype does not offer expanded immunity to protect against subsequent infections with a different HCV genotype. A prophylactic HCV vaccine boosted with multiple HCV genotype may offer a broader and more effective protection

Cohort profile: the British Columbia COVID-19 Cohort (BCC19C)—a dynamic, linked population-based cohort

PurposeThe British Columbia COVID-19 Cohort (BCC19C) was developed from an innovative, dynamic surveillance platform and is accessed/analyzed through a cloud-based environment. The platform integrates recently developed provincial COVID-19 datasets (refreshed daily) with existing administrative holdings and provincial registries (refreshed weekly/monthly). The platform/cohort were established to inform the COVID-19 response in near “real-time” and to answer more in-depth epidemiologic questions.ParticipantsThe surveillance platform facilitates the creation of large, up-to-date analytic cohorts of people accessing COVID-19 related services and their linked medical histories. The program of work focused on creating/analyzing these cohorts is referred to as the BCC19C. The administrative/registry datasets integrated within the platform are not specific to COVID-19 and allow for selection of “control” individuals who have not accessed COVID-19 services.Findings to dateThe platform has vastly broadened the range of COVID-19 analyses possible, and outputs from BCC19C analyses have been used to create dashboards, support routine reporting and contribute to the peer-reviewed literature. Published manuscripts (total of 15 as of July, 2023) have appeared in high-profile publications, generated significant media attention and informed policy and programming. In this paper, we conducted an analysis to identify sociodemographic and health characteristics associated with receiving SARS-CoV-2 laboratory testing, testing positive, and being fully vaccinated. Other published analyses have compared the relative clinical severity of different variants of concern; quantified the high “real-world” effectiveness of vaccines in addition to the higher risk of myocarditis among younger males following a 2nd dose of an mRNA vaccine; developed and validated an algorithm for identifying long-COVID patients in administrative data; identified a higher rate of diabetes and healthcare utilization among people with long-COVID; and measured the impact of the pandemic on mental health, among other analyses.Future plansWhile the global COVID-19 health emergency has ended, our program of work remains robust. We plan to integrate additional datasets into the surveillance platform to further improve and expand covariate measurement and scope of analyses. Our analyses continue to focus on retrospective studies of various aspects of the COVID-19 pandemic, as well as prospective assessment of post-acute COVID-19 conditions and other impacts of the pandemic

School Absenteeism As an Adjunct Surveillance Indicator: Experience during the Second Wave of the 2009 H1N1 Pandemic in Quebec, Canada

A school absenteeism surveillance system was implemented in the province of Quebec, Canada during the second wave of the 2009 H1N1 pandemic. This paper compares this surveillance approach with other available indicators.All (3432) elementary and high schools from Quebec were included. Each school was required to report through a web-based system any day where the proportion of students absent for influenza-like illness (ILI) exceeded 10% of current school enrolment.Between October 18 and December 12 2009, 35.6% of all schools met the 10% absenteeism threshold. This proportion was greater in elementary compared to high schools (40% vs 19%) and in smaller compared to larger schools (44% vs 22%). The maximum absenteeism rate was reached the first day of reporting or within the next two days in 55% and 31% of schools respectively. The first reports and subsequent peak in school absenteeism provincially preceded the peak in paediatric hospitalization by two and one weeks, respectively. Trends in school surveillance otherwise mirrored other indicators.During a pandemic, school outbreak surveillance based on a 10% threshold appears insufficient to trigger timely intervention within a given affected school. However, school surveillance appears well-correlated and slightly anticipatory compared to other population indicators. As such, school absenteeism warrants further evaluation as an adjunct surveillance indicator whose overall utility will depend upon specified objectives, and other existing capacity for monitoring and response

Acute health effects of the Tasman Spirit oil spill on residents of Karachi, Pakistan

BACKGROUND: On July 27 2003, a ship carrying crude oil run aground near Karachi and after two weeks released 37,000 tons of its cargo into the sea. Oil on the coastal areas and fumes in air raised health concerns among people. We assessed the immediate health impact of oil spill from the tanker Tasman Spirit on residents of the affected coastline in Karachi, Pakistan. METHODS: We conducted a study consisting of an exposed group including adults living in houses on the affected shoreline and two control groups (A and B) who lived at the distance of 2 km and 20 km away from the sea, respectively. We selected households through systematic sampling and interviewed an adult male and female in each household about symptoms relating to eyes, respiratory tract, skin and nervous system, smoking, allergies, beliefs about the effect on their health and anxiety about the health effects. We used logistic regression procedures to model each symptom as an outcome and the exposure status as an independent variable while adjusting for confounders. We also used linear regression procedure to assess the relationship exposure status with symptoms score; calculated by summation of all symptoms. RESULTS: Overall 400 subjects were interviewed (exposed, n = 216; group A, n = 83; and group B, n = 101). The exposed group reported a higher occurrence of one or more symptoms compared to either of the control groups (exposed, 96% vs. group A, 70%, group B 85%; P < 0.001). Mean summary symptom scores were higher among the exposed group (14.5) than control group A (4.5) and control group B (3.8, P < 0.001). Logistic regression models indicated that there were statistically significant, moderate-to-strong associations (Prevalence ORs (POR) ranging from 2.3 to 37.0) between the exposed group and the symptoms. There was a trend of decreasing symptom-specific PORs with increase in distance from the spill site. Multiple linear regression model revealed strong relationship of exposure status with the symptoms score (β = 8.24, 95% CI: 6.37 – 10.12). CONCLUSION: Results suggest that the occurrence of increased symptoms among the exposed group is more likely to be due to exposure to the crude oil spill

Injection practices in Sindh Province, Pakistan : a cross-sectional study

Injections are highly popular and overused in developing countries. However, the international public health community has been increasingly concerned about their role in spread of blood-borne pathogens, post-injection abscesses, and poliomyelitis provocation paralysis. The increasing use of injections is putting financial burden on health care resources. Reducing the frequency of therapeutic injections is corner stone in improving the injection safety. Such a programme may be better conducted if initial assessments are made to estimate the frequency of injections and to identify the determinants of injection overuse among patients and health care providers. The objective of the study was to estimate the frequency of injections and identification of injection providers in a rural and urban community of Sindh province in Pakistan. We also identified the determinants of injection use. From 25ft July to 30fr September 2001 we interviewed 575 subjects each in rural and urban setting through cluster survey technique divided in 34 clusters. A structured questionnaire was administered to the respondent age \u3e15 years and to the guardian below this age. Information was collected about encounters with providers, reason for encounter, type of medication prescribed, and number and types of injections during last three months. Respondents were also inquired about their beliefs regarding injections. Age and sex standardized estimates of injection frequency were calculated and determinants of receiving an injection during last three months were identified using multiple logistic regression analysis. The mean number of injections was 3.8 injections/person during last three months (15 injections/person/year). Sixty-eight percent of the subjects received at least one injection during the past three months. No gender difference was seen in frequency of injections. Most of the injections (96%) were for therapeutic purposes and were administered at general practitioner\u27s clinic (74%) by a dispenser or a nurse (75%). Of those who remembered last injection, 5l% were administered with sterile injection equipment. Residents of rural area (adjusted OR=6.6; 95% Cl: 3.1-14.2), and those who visited a private GP (adjusted OR=3.5; 95% CI: 1.9-6.3) or dispenser (adjusted OR=6.2; 95% CI 2.8-14.2) were more likely to receive an injection. Those who had a belief that injections act faster than oral medication and symptoms are quickly relieved (adjusted OR= 1.4; 95% Cl: 1.l-1.7) or illness can only be treated with injectable medications (adjusted OR= 2.4; 95% Cl: 1.4-4.3) were also more likely to receive injections during past three months. Injections are overused in the Sindh province of Pakistan, with ratios of injection per capita among the highest ever reported. Beliefs of patients about injection superiority over oral drugs in treatment of their ailments are among the major contributors of injection use. Interventions are needed to obtain a reduction of injection prescription among private health care providers who prescribe most of the injections received by the population, and modifications of beliefs about injection among patients