1 research outputs found
Redox Potential Ultrasensitive Nanoparticle for the Targeted Delivery of Camptothecin to HER2-Positive Cancer Cells
Ideal
“smart” nanoparticles for drug delivery should
enhance therapeutic efficacy without introducing side effects. To
achieve that, we developed a drug delivery system (HCN) based on a
polymer–drug conjugate of poly[2-(pyridin-2-yldisulfanyl)]-<i>graft</i>-poly(ethylene glycol) and camptothecin with an intracellularly
cleavable linker and human epidermal growth factor receptor 2 (HER2)
targeting ligands. An <i>in vitro</i> drug release study
found that HCN was stable in the physiological environment and supersensitive
to the stimulus of elevated intracellular redox potential, releasing
all payloads in less than 30 min. Furthermore, confocal microscopy
revealed that HCN could specifically enter HER2-positive cancer cells.
As a consequence, HCN could effectively kill HER2-positive cancer
cells while not affecting HER2-negative cells