56 research outputs found
Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism
Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development
Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopy
Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit model**Presented in part in Chest 128 (4) 301S (October 2005) and Journal of Investigative Medicine 53 (1) S113 (January 2005) as abstracts.
Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy
Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit model.
Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits
Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy.
Broadband diffuse optical spectroscopy assessment of hemorrhage- and hemoglobin-based blood substitute resuscitation.
Monitoring Dose Response of Cyanide Antidote Dimethyl Trisulfide in Rabbits Using Diffuse Optical Spectroscopy.
Correction to: Monitoring Dose Response of Cyanide Antidote Dimethyl Trisulfide in Rabbits Using Diffuse Optical Spectroscopy
- …