ORIGINAL ARTICLE: In-vitro Antioxidant Potential of a Herbal Preparation Containing Four Selected Medicinal Plants

Background: The therapeutic effects of several plants used in traditional medicine, are usually attributed to their antioxidant properties. Aim and objective: To evaluate the in-vitro antioxidant potential of herbal preparation a combination of four selected medicinal plants (HP-4) using different experimental models.Material and Methods: Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of herbal preparation (HP-4)as compared to butylated hydroxyl toluene (BHT) and á- tocopherol in various experimental models were evaluated. Results: The antioxidantactivities of HP-4 were concentration dependent in different experimental models and were comparable to activities of BHT anda- tocopherol. Conclusion: Polyherbal formulation of HP-4 is better than individual plant extracts

<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Virtual screening and docking exploration on estrogen receptor: An <i>in silico</i> approach to decipher novel anticancer agents</span>

389-395Breast cancer is a prominent disorder that affects mostly mid aged women with a high intensity, upsetting every ninth women of ten. The available drugs and treatments fall back as they do not completely eradicate the cancerous cells from body. Hence, newer and more effective drugs and treatments against breast cancer are the need-of-hour. The increased level of estrogen within body increases the chance of breast cancer, whereas the regular concentration plays significant role in normal cell functioning. Melatonin is popularly used as an anti-estrogenic compound, whereas violacein an active secondary metabolite secreted by bacteria like ‘Chromobacterium violaceum’ has strong structural similarity with melatonin and, thus, possess latency of being tested for its anti-cancerous activity. In the current study, docking and virtual screening was utilized to prove the fact that violacein and similar compounds can bind more efficiently to estrogen receptor than that of melatonin and, hence, has potential to emerge as lead anti-estrogenic compound in treatment of breast cancer. </span