GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein

GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor phospho-dependent regulation using PRIP-1(-/-) mice. In wild-type animals, robust phosphorylation and functional modulation of GABA(A) receptors containing beta3 subunits by cAMP-dependent protein kinase was evident, which was diminished in PRIP-1(-/-) mice. PRIP-1(-/-) mice exhibited enhanced PP1alpha activity compared with controls. Furthermore, PRIP-1 was able to interact directly with GABA(A) receptor beta subunits, and moreover, these proteins were found to be PP1alpha substrates. Finally, phosphorylation of PRIP-1 on threonine 94 facilitated the dissociation of PP1alpha-PRIP-1 complexes, providing a local mechanism for the activation of PP1alpha. Together, these results suggest an essential role for PRIP-1 in controlling GABA(A) receptor activity via regulating subunit phosphorylation and thereby the efficacy of neuronal inhibition mediated by these receptors

Type I Migration in a Non-Isothermal Protoplanetary Disk

We calculate rates of Type I migration of protoplanets in a non-isothermal three-dimensional protoplanetary disk, building upon planet-disk models developed in previous work. We find that including the vertical thickness of the disk results in a decrease in the Type I migration rate by a factor of ~2 from a two-dimensional disk. The vertical temperature variation has only a modest effect on migration rates since the torques at the midplane are weighted heavily both because the density and the perturbing potential are maximized at the midplane. However, temperature perturbations resulting from shadowing and illumination at the disk's surface can decrease the migration rate by up to another factor of 2 for planets at the gap-opening threshold at distances where viscous heating is minimal. This would help to resolve the timescale mismatch between the standard core-accretion scenario for planet formation and the survival of planets, and could help explain some of the rich diversity of planetary systems already observed.Comment: 9 pages, 8 figures. Accepted to the Astrophysical Journa

Segmentation of Loops from Coronal EUV Images

We present a procedure which extracts bright loop features from solar EUV images. In terms of image intensities, these features are elongated ridge-like intensity maxima. To discriminate the maxima, we need information about the spatial derivatives of the image intensity. Commonly, the derivative estimates are strongly affected by image noise. We therefore use a regularized estimation of the derivative which is then used to interpolate a discrete vector field of ridge points ``ridgels'' which are positioned on the ridge center and have the intrinsic orientation of the local ridge direction. A scheme is proposed to connect ridgels to smooth, spline-represented curves which fit the observed loops. Finally, a half-automated user interface allows one to merge or split, eliminate or select loop fits obtained form the above procedure. In this paper we apply our tool to one of the first EUV images observed by the SECCHI instrument onboard the recently launched STEREO spacecraft. We compare the extracted loops with projected field lines computed from almost-simultaneously-taken magnetograms measured by the SOHO/MDI Doppler imager. The field lines were calculated using a linear force-free field model. This comparison allows one to verify faint and spurious loop connections produced by our segmentation tool and it also helps to prove the quality of the magnetic-field model where well-identified loop structures comply with field-line projections. We also discuss further potential applications of our tool such as loop oscillations and stereoscopy.Comment: 13 pages, 9 figures, Solar Physics, online firs

Correlation effects in CaCu3Ru4O12

We have investigated the electronic structure of CaCu3Ru4O12 and LaCu3Ru4O12 using soft x-ray photoelectron and absorption spectroscopy together with band structure and cluster configuration interaction calculations. We found the Cu to be in a robust divalent ionic state while the Ru is more itinerant in character and stabilizes the metallic state. Substitution of Ca by La predominantly affects the Ru states. We observed strong correlation effects in the Cu 3d states affecting the valence band line shape considerably. Using resonant photoelectron spectroscopy at the Cu L3 edge we were able to unveil the position of the Zhang-Rice singlet states in the one-electron removal spectrum of the Cu with respect to the Ru-derived metallic bands in the vicinity of the chemical potential

Multivariate p-dic L-function

We construct multivariate p-adic L-function in the p-adic number fild by using Washington method.Comment: 9 page

Charge states and magnetic ordering in LaMnO3/SrTiO3 superlattices

We investigated the magnetic and optical properties of [(LaMnO3)n/(SrTiO3)8]20 (n = 1, 2, and 8) superlattices grown by pulsed laser deposition. We found a weak ferromagnetic and semiconducting state developed in all superlattices. An analysis of the optical conductivity showed that the LaMnO3 layers in the superlattices were slightly doped. The amount of doping was almost identical regardless of the LaMnO3 layer thickness up to eight unit cells, suggesting that the effect is not limited to the interface. On the other hand, the magnetic ordering became less stable as the LaMnO3 layer thickness decreased, probably due to a dimensional effect.Comment: 17 pages including 4 figures, accepted for publication in Phys. Rev.

Hysteresis and the dynamic phase transition in thin ferromagnetic films

Hysteresis and the non-equilibrium dynamic phase transition in thin magnetic films subject to an oscillatory external field have been studied by Monte Carlo simulation. The model under investigation is a classical Heisenberg spin system with a bilinear exchange anisotropy in a planar thin film geometry with competing surface fields. The film exhibits a non-equilibrium phase transition between dynamically ordered and dynamically disordered phases characterized by a critical temperature Tcd, whose location of is determined by the amplitude H0 and frequency w of the applied oscillatory field. In the presence of competing surface fields the critical temperature of the ferromagnetic-paramagnetic transition for the film is suppressed from the bulk system value, Tc, to the interface localization-delocalization temperature Tci. The simulations show that in general Tcd < Tci for the model film. The profile of the time-dependent layer magnetization across the film shows that the dynamically ordered and dynamically disordered phases coexist within the film for T < Tcd. In the presence of competing surface fields, the dynamically ordered phase is localized at one surface of the film.Comment: PDF file, 21 pages including 8 figure pages; added references,typos added; to be published in PR

High-index and low-loss topological insulators for mid-infrared nanophotonics

Topological insulators generally have dielectric bulk and conductive surface states. Consequently, some of these materials have been shown to support polaritonic modes at visible and THz frequencies. At the same time, the optical properties of topological insulators in the mid-infrared (IR) remain poorly investigated. We employ near-field imaging to probe the mid-IR response from the exfoliated flakes of bismuth (Bi) / selenide (Se) / telluride (Te) / antimony (Sb) crystals with varying stoichiometry - Bi2Se3, Bi2Te2Se, and Bi1.5Sb0.5Te1.7Se1.3 - in pristine form as well as covered by thin flakes of hexagonal boron nitride (hBN). Contrary to theoretical expectations, all three materials exhibit a dielectric response with a high refractive index and with a loss below the experimental detection limit. Particularly, the near-field mapping of propagating phonon-polaritons in hBN demonstrates that these van der Waals crystals act as a practically lossless dielectric substrate with an ultra-high refractive index of up to 7.5 in Bi2Te2Se. Such a unique dielectric crystal would be of great advantage for numerous nanophotonic applications in the mid-IR

Some Comments on Gravitational Entropy and the Inverse Mean Curvature Flow

The Geroch-Wald-Jang-Huisken-Ilmanen approach to the positive energy problem to may be extended to give a negative lower bound for the mass of asymptotically Anti-de-Sitter spacetimes containing horizons with exotic topologies having ends or infinities of the form $\Sigma_g \times {\Bbb R}$, in terms of the cosmological constant. We also show how the method gives a lower bound for for the mass of time-symmetric initial data sets for black holes with vectors and scalars in terms of the mass, $|Z(Q,P)|$ of the double extreme black hole with the same charges. I also give a lower bound for the area of an apparent horizon, and hence a lower bound for the entropy in terms of the same function $|Z(Q,P)|$. This shows that the so-called attractor behaviour extends beyond the static spherically symmetric case. and underscores the general importance of the function $|Z(Q,P)|$. There are hints that higher dimensional generalizations may involve the Yamabe conjectures.Comment: 13pp. late

Annihilation of Charged Particles

The kinetics of irreversible annihilation of charged particles performing overdamped motion induced by long-range interaction force, $F(r)\sim r^{-\lambda}$, is investigated. The system exhibits rich kinetic behaviors depending on the force exponent $\lambda$. In one dimension we find that the densities decay as $t^{-1/(2+\lambda)}$ and $t^{-1/(1+2\lambda)}$ when $\lambda>1$ and $1/2<\lambda<1$, respectively, with logarithmic correction at $\lambda=1$. For $\lambda \leq 1/2$, the asymptotic behavior is shown to be dependent on system size.Comment: 17 pages, plain TeX, 3 figures available upon request from [email protected]