2 research outputs found
Library Approach for Reliable Synthesis and Properties of DNA–Gold Nanorod Conjugates
We
developed a library-based approach to chemically stabilize cetyltrimethylammonium
bromide (CTAB)-coated gold nanorods for the synthesis of polyvalent
DNA–gold nanorod conjugates (DNA–AuNRs). Eleven chemical
reagents were carefully chosen to constitute an additive library and
screened by UV–vis spectroscopy to evaluate their stabilizing
capability for the CTAB-coated AuNRs. Interestingly, 5-bromosalicylic
acid (5-BrSA) was determined to most significantly stabilize the AuNRs
by inducing additional adsorption of CTAB on the rod. Importantly,
these stabilized AuNRs with 5-BrSA were conjugated with thiol DNA
in an exceptionally reproducible and reliable method, which led to
the systematic investigation of their cooperative assembly and disassembly
properties under various conditions, including different types and
lengths of the DNA sequences
Visualization 1: In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells
The xenograft tumor mass was illuminated using a NIR laser at an irradiance of 1 W/cm2 for 2 minutes Originally published in Biomedical Optics Express on 01 January 2016 (boe-7-1-185